Administration Core

行政核心

• 批准号: 10629081
• 负责人: Xue Sean Li
• 金额: $ 14.57万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629081
• 关键词: Accountability; Advisory Committees; Biological Process; Chromosomes; Collaborations; Communication; Data; Direct Expenditure; Ensure; Extramural Activities; Female; Gender; Goals; Grant; Immunity; Incidence; Individual; Institution; Knowledge; Laws; Leadership; Malignant Neoplasms; Malignant neoplasm of urinary bladder; Medicine; Minority Health Research; Molecular; Monitor; Odds Ratio; Persons; Policies; Program Research Project Grants; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk Factors; Science; Secure; Services; Sex Bias; Sex Differences; Tissues; United States National Institutes of Health; Update; Woman; Work; data integrity; data management; data sharing; ethnic minority; male; member; men; mortality; programs; sex; sexual dimorphism; symposium; synergism; virtual; web site

ADMINISTRATIVE CORE – SUMMARY Men are more likely to develop cancer than women in nearly every non-reproductive tissue type. Bladder cancer typifies this sex-bias phenomenon as the male-to-female risk ratio ranking 1st in mortality and 2nd in incidence. This male-bias persists even after adjustment for other known risk factors, supporting the idea that a fundamental biological process(es) underlies sexual dimorphism. The overall goal of this Program Project Grant (PPG) is to elucidate the molecular and cellular mechanisms underlying sex-biased incidence and mortality seen in bladder cancer. The Administrative Core (Admin Core) provides the leadership for overall scientific direction and program oversight and administrative, fiscal, and organizational coordination of all research activities of Projects and shared Resource Cores. The Specific Aims of the Admin Core are as follows. Aim 1: To provide leadership for overall scientific direction and program oversight. This includes setting the research agenda focused on advancing basic understanding of sex differences in bladder cancer. The Admin Core will oversee programmatic activities including scientific integrity, data management and ensuring data integrity, and direct expenditures. Aim 2: To facilitate communication and integration of the PPG investigators and Resource Core leaders. In addition to regular monthly virtual and in-person progress updates and communications, the Admin Core will facilitate constructive review and enhancement of research progress through frequent and deliberate interactions with subject matter experts via Internal and External Scientific Advisory Committees. Aim 3: To provide overall administrative and fiscal management support. This includes ensuring compliance with all terms and conditions of the grant, and consulting and communicating with extramural NCI/NIH staff in submitting all necessary internal and external research reports. The Admin Core will also establish and monitor policies for inclusion of women and ethnic minorities in research related to sex differences in bladder cancer.

行政核心——总结 在几乎所有可能的非生殖组织癌类型中，男性比女性更容易患癌症。 这种性别偏见现象的典型代表是，男性与女性的风险比在死亡率上排名第一，在发病率上排名第二。 即使在对其他已知风险因素进行调整后，这种男性偏见仍然存在，这支持了以下观点： 生物过程是性别二态性的基础。该计划项目拨款 (PPG) 的总体目标是 阐明膀胱中性别偏见发病率和死亡率的分子和细胞机制 行政核心（Admin Core）为科学方向和计划提供总体领导。 对项目和项目的所有研究活动进行监督和行政、财政和组织协调 管理核心的具体目标如下： 提供领导。 总体科学方向和项目监督包括制定重点研究议程。 促进对膀胱癌性别差异的基本了解。管理核心将监督程序化。 活动包括科学完整性、数据管理和确保数据完整性以及直接支出。 目标 2：促进 PPG 调查人员和资源核心领导者的沟通和整合。 除了每月定期进行虚拟和面对面的进度更新和沟通外，管理核心还将 通过频繁和深思熟虑的互动，促进研究进展的建设性审查和加强 通过内部和外部科学咨询委员会与主题专家合作 目标 3：提供全面的信息。 这包括确保遵守所有条款和条件。 拨款的情况，并与 NCI/NIH 外部工作人员进行咨询和沟通，以提交所有必要的内部信息 管理核心还将制定和监督女性包容性政策。 和少数民族参与膀胱癌性别差异相关的研究。