Avoiding Cesarean-induced Obesity Through Hormone Rescue

通过激素拯救避免剖腹产引起的肥胖

• 批准号: 10628889
• 负责人: William Kenkel
• 金额: $ 34.58万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628889
• 关键词: Adrenal Cortex Hormones; Adult; Affect; Anatomy; Animals; Argipressin; Behavior; Birth; Body Composition; Body Temperature; Brain; Brain region; Budgets; Cesarean section; Child; Childhood; Chronic; Complement; Corticosterone; Dangerousness; Desire for food; Development; Eating; Elderly; Endocrine; Energy Metabolism; Equilibrium; Fetal Development; Health; Heart Rate; Histology; Home; Hormones; Housing; Human; Hypothalamic structure; Implant; Intervention; Life; Ligands; Mammals; Measures; Metabolic; Metabolism; Microtus; Modeling; Motor Activity; Nature; Neuroendocrinology; Neuropeptides; Neurosecretory Systems; Newborn Infant; Obesity; Outcome; Oxytocin; Physiologic Thermoregulation; Physiology; Play; Population; Prevalence; Public Health; Regulation; Research; Rest; Rewards; Risk; Risk Factors; Rodent; Rodent Model; Role; Signal Transduction; Social Behavior; Sucrose; Surveys; System; Technology; Temperature; Testing; United States; Vaginal delivery procedure; Vasopressins; Visceral; Weight Gain; Work; cold stress; corticosterone receptor; cost effective; data streams; energy balance; experience; food consumption; hormonal signals; hormone regulation; improved; lens; morphometry; neuroimaging; neuroregulation; novel; obesity development; obesity in children; obesity risk; offspring; pharmacologic; prairie vole; preference

Project Summary / Abstract Delivery via cesarean section (CS) now makes up roughly one third of all births in the United States. After CS delivery, newborns experience lower levels of several ‘birth signaling hormones’ such as oxytocin, vasopressin, and corticosteroids. Birth is a sensitive period for the signaling of these hormones, and so changes in their levels at birth can affect their regulation throughout development. Besides being involved in birth, these same hormones also regulate metabolism behavior in later life. We hypothesize this is why delivery by CS is associated with substantially higher rates of childhood obesity. We have begun to explore the connections between birth mode and subsequent metabolic regulation using the prairie vole (Microtus ochrogaster). The prairie vole is one of the few rodent models that allows us to examine the physiology underlying energy regulation without the burden of chronic cold stress brought on by conventional, room temperature housing. Our recent findings suggest that prairie voles delivered via CS experience changes in their thermoregulation, social behavior, and metabolic regulation sufficient to produce increased weight gain across development. In the present study, we will investigate this further to assess whether voles delivered by CS are at increased risk for visceral adiposity -one of the most dangerous aspects of obesity in humans. We will fully characterize subjects’ energy budgets as well as the brain functioning that underlies metabolism in terms of anatomy, connectivity and the regulation of the birth signaling hormones. Finally, we test whether replacing the missing hormone surge in CS newborns can avoid the metabolic outcomes typically seen in children and voles delivered by CS. In so doing, we hope to offer a simple, straightforward, and cost-effective strategy to reduce childhood obesity in this population. We hypothesize that a CS delivery represents delivery without the full complement of birth signaling hormones and as such will result differences in neuroendocrinology and metabolism throughout development.

项目摘要 /摘要 现在，通过剖宫产部分（CS）分娩，大约使美国所有出生的三分之一。 CS分娩后，新生儿经历了几种“出生信号激素”的较低水平，例如催产素， 加压素和皮质类固醇。出生是这些激素信号的敏感时期，因此 出生时水平的变化会影响他们在整个发展中的调节。除了参与 生日，这些相同的骑兵还调节了后来的新陈代谢行为。我们假设这就是为什么交付的原因 CS与儿童对象的率相关。我们已经开始探索 使用Prairie Vole（Microtus）出生模式与随后的代谢调节之间的连接 Ochrogaster）。草原田鼠是允许我们检查生理学的少数几个啮齿动物模型之一 基本的能量调节，而没有传统的房间带来的慢性冷应力的伯宁 温度外壳。我们最近的发现表明，通过CS交付的草原田鼠体验了变化 他们的体温调节，社会行为和代谢调节足以增加体重增加 整个发展。在本研究中，我们将进一步研究以评估是否由 CS的内脏肥胖风险增加 - 人类肥胖症最危险的方面之一。我们 将充分表征受试者的能量预算以及构成新陈代谢的大脑功能 解剖学，连通性和出生信号激素的调节。最后，我们测试是否 替换CS新生儿中缺失的骑马激增可以避免在 CS分娩的儿童和田鼠。这样做，我们希望提供一个简单，直接且具有成本效益的 减少该人群中儿童对象的策略。我们假设CS交付代表交付 没有完整完成出生信号激素的完整完成，因此将导致差异 整个发展中的神经内分泌学和代谢。