Integrative Analysis of Metabolic Phenotypes (IAMP) Predoctoral Training Program

代谢表型综合分析（IAMP）博士前培训项目

• 批准号: 10626745
• 负责人: Andrew Patterson
• 金额: $ 19.72万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626745
• 关键词: Training Programs; metabolic phenotype; pre-doctoral

PROJECT SUMMARY The Penn State `Integrative Analysis of Metabolic Phenotypes (IAMP) Predoctoral Training Program' will train a future generation of scientists in experimental, molecular, and bioinformatics approaches applied towards integrating our understanding of the host metabolism in health and disease. The training program will build upon established graduate programs in biochemistry, biology, molecular, cellular and developmental biology, nutritional science, bioinformatics and genomics. The program is designed to train future generations of experimentalists with a leading expertise in metabolism, microbiology, and biophysical/network modeling in addressing fundamental questions in metabolism and its impact on host physiology. There is a tremendous need to provide trainees with the fundamental knowledge pertaining to metabolism, metabolomics, and the microbiome and train them in the use of novel and cutting-edge tools (e.g., mass spectrometry, nuclear magnetic resonance spectroscopy, next generation sequencing) to study these issues throughout their graduate training and future careers. The proposed IAMP training program will train a diverse cohort of young scientists to have critical expertise in biochemistry, microbiology, nutritional science, molecular biology, bioinformatics and statistics to address fundamental questions in host physiology and factors that may influence the metabolic phenotype. The program will be anchored within the Center for Molecular Toxicology and Carcinogenesis, which has been a focal point for collaborators for more than 20 years and the newly formed Penn State Cancer Institute with additional contributions from other key centers. The training program will connect and further develop seven established graduate programs: Biochemistry, Microbiology and Molecular Biology (BMMB), Bioinformatics and Genomics (BG), Biology (BIOL), Chemistry (CHEM), Molecular, Cellular and Integrative Biosciences (MCIBS), Nutritional Sciences (NUTR), and Pathobiology (PATAHOBIOL). Combining NIH and Penn State support, IAMP program plans to train a minimum of 19 predoctoral students over a period of five years. Each trainee will be supported for the two years of their training (year 2 and 3) while receiving foundational training in IAMP. Trainees will gain enough understanding of the scientific process, responsible conduct in science, fluency in cutting edge metabolomic platforms and technologies, ability to utilize data integration approaches, and excellence in communication and leadership in cross disciplinary teams.

项目摘要 宾夕法尼亚州“代谢表型的综合分析（IAMP）训练计划”将训练 实验，分子和生物信息学方法的未来科学家适用于 整合我们对健康和疾病中宿主代谢的理解。培训计划将基于 建立的生物化学，生物学，分子，细胞和发育生物学的研究生计划， 营养科学，生物信息学和基因组学。该计划旨在培训子孙后代 具有代谢，微生物学和生物物理/网络建模领域的领先专业知识的实验者 解决代谢中的基本问题及其对宿主生理的影响。有很大的需求 为学员提供与代谢，代谢组学和 微生物组并训练它们使用新颖和尖端工具（例如质谱，核磁性 共振光谱，下一代测序）在整个研究生培训中研究这些问题 和未来的职业。拟议的IAMP培训计划将培训各种各样的年轻科学家 生物化学，微生物学，营养科学，分子生物学，生物信息学和生物信息学和 解决宿主生理学中基本问题的统计数据以及可能影响代谢的因素 表型。该程序将锚定在分子毒理学和癌变中心中，该中心 已有20多年的合作者是合作者的焦点，而新成立的宾夕法尼亚州立癌症研究所 还有其他主要中心的额外贡献。培训计划将连接并进一步发展七个 成熟的研究生课程：生物化学，微生物学和分子生物学（BMMB），生物信息学和 基因组学（BG），生物学（生物学），化学（化学），分子，细胞和综合生物科学（MCIBS）， 营养科学（NUTR）和病理生物学（Patahobiol）。联合NIH和Penn State Support，IAMP 计划计划在五年的时间内至少培训19名专业学生。每个学员将 在接受IAMP的基础培训的同时，他们的培训两年（第2年和第3年）支持。学员 将对科学过程，科学的负责行为，尖端的流利程度获得足够的了解 代谢组平台和技术，使用数据集成方法的能力以及卓越 跨学科团队的沟通和领导。

项目成果

Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production.

• DOI: 10.1002/cnr2.1863
• 发表时间: 2023-11
• 期刊: Cancer reports (Hoboken, N.J.)
• 作者: Tian S;Paudel D;Hao F;Neupane R;Castro R;Patterson AD;Tiwari AK;Prabhu KS;Singh V
• 通讯作者: Singh V

Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites.

• DOI: 10.3390/metabo13090985
• 发表时间: 2023-08-31
• 期刊: Metabolites
• 影响因子: 4.1
• 作者: Patel D;Murray IA;Dong F;Annalora AJ;Gowda K;Coslo DM;Krzeminski J;Koo I;Hao F;Amin SG;Marcus CB;Patterson AD;Perdew GH
• 通讯作者: Perdew GH

The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation.

• DOI: 10.1073/pnas.2210929120
• 发表时间: 2023-04-25
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1

Menopausal stage differences in endothelial resistance to ischemia-reperfusion injury.

• DOI: 10.14814/phy2.15768
• 发表时间: 2023-09
• 期刊: Physiological reports
• 影响因子: 2.5

A Cross-Sectional Study of Dairy Cattle Metagenomes Reveals Increased Antimicrobial Resistance in Animals Farmed in a Heavy Metal Contaminated Environment.

• DOI: 10.3389/fmicb.2020.590325
• 发表时间: 2020
• 期刊: Frontiers in microbiology
• 影响因子: 5.2
• 作者: Gaeta NC;Bean E;Miles AM;de Carvalho DUOG;Alemán MAR;Carvalho JS;Gregory L;Ganda E
• 通讯作者: Ganda E