Predoctoral Training Program in Quantitative Mechanobiology

定量力学生物学博士前培训项目

• 批准号: 10626763
• 负责人: Beth L Pruitt
• 金额: $ 30.98万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA BARBARA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626763
• 关键词: Training Programs; pre-doctoral

Project Summary/Abstract This application seeks funding for a new Interdisciplinary Predoctoral Training Program in Quantitative Mechanobiology at University of California, Santa Barbara (UCSB). The Program brings biologists, physicists, and engineers together to pursue fundamental understanding of the biophysical principles underlying human health spanning molecular to organismal level processes of mechanosignaling in development, homeostasis and disease. The focus of this initiative is cross-disciplinary training in mechanobiology, i.e., relationships between physical forces and biological structure and function, to produce a new cadre of bioscientists who will develop quantitative solutions to biology’s most challenging problems. If funded, the Training Program in Quantitative Mechanobiology will be UCSB’s first training grant and will serve as a flagship predoctoral training program that nucleates a connected community across the many labs already conducting mechanobiology research at UCSB through peer-to-peer interactions, cross-lab training, seminars, courses, and an annual symposium/retreat. The Program will provide support for Fellows to undertake three research rotations in their first year and opportunities for unique cross-training in mechanobiology. Each year, six Mechanobiology Fellows will be admitted with a steady state Program size of twelve predoctoral training slots. The Program will recruit and support Fellows from six graduate degree programs and augment their PhD programs with training in quantitative bioscience methods, engineering models and devices, and multi-disciplinary cross-training to develop and apply quantitative approaches to problems in mechanobiology. To provide optimal interdisciplinary mentorship and research training experiences, each Fellow will work with their project PI and will also be assigned a Program Mentor with complementary seniority, quantitative, experimental, and analytical approaches. The Program Mentor will also serve on the Fellow’s dissertation committee. This chain of mentorship is supported by formal Mentor trainings and leverages our mix of junior and senior Faculty Mentors to support both our Fellows and our junior Faculty Mentors. Fellows will benefit from formalized interactions with the diverse community of faculty and peers, as well as resources, associated with Program and affiliated graduate programs. Key components of the Program include formalized training in Responsible Conduct of Research, Quantitative Experiments, didactic and hands-on training in methods and analytical techniques in a Mechanobiology Methods course and quarterly “open door” lab sessions in Faculty Mentor labs. The Program will feature monthly seminars with peers, visiting researchers, and Faculty Mentors as well as career development activities, and an annual symposium/retreat uniting the entire UCSB mechanobiology community. Trainees from diverse disciplines, backgrounds, and groups will be prepared to lead rigorous biomedical research programs and promote scientific advances in academia, industry, national labs, and technology and policy careers.

项目摘要/摘要 该申请为定量的新跨学科培训计划寻求资金 加利福尼亚大学圣塔芭芭拉分校（UCSB）的机械生物学。该计划带来了生物学家，物理学家， 和工程师共同追求对人类基础的生物物理原理的基本理解 跨越分子到开发中的机械信号的有机水平过程，体内平衡 和疾病。该计划的重点是机械生物学的跨学科培训，即关系 在物理力和生物结构和功能之间，生产新的生物科学家干部，他们将 开发针对生物学最挑战性问题的定量解决方案。如果资助，培训计划 定量机械生物学将成为UCSB的首个培训补助金，并将作为旗舰店培训 计划核能核能跨许多实验室的连接社区，已经进行了机制 通过点对点互动，跨LAB培训，半手，课程和一年一度的年度研究，在UCSB进行研究 研讨会/撤退。该计划将为研究员提供支持，以进行三个研究轮换 第一年和机制独特交叉训练的机会。每年，六个机械生物学 研究员将被稳态计划的大小为十二个训练位。该程序将 六个研究生学位课程的招募和支持研究员，并通过培训增强其博士学位课程 在定量生物科学方法，工程模型和设备以及多学科跨训练中 开发和应用定量方法来解决机制问题。提供最佳的跨学科 属性和研究培训经验，每个人都将与他们的项目PI合作，也将是 分配了一个具有完整资历，定量，实验和分析的计划导师 方法。该计划导师还将在同学论文委员会任职。这个链 Mentalship得到了正式的导师培训的支持，并利用了我们的初级和高级教师导师的组合 支持我们的研究员和我们的初级教师导师。研究员将受益于形式上的互动 与计划和会员相关的潜水员社区以及资源 研究生课程。该计划的关键组成部分包括负责任的正式培训 研究，定量实验，方法和分析技术的教学和动手培训 机械生物学方法课程和教师指导实验室中的季度“开门”实验室会议。该程序 将每月与同龄人，访问研究人员和教师导师以及职业的下水道一起 开发活动，以及将整个UCSB机械生物学社区团结在一起的年度研讨会/务虚会。 来自潜水员学科，背景和团体的学员将准备领导严格的生物医学 研究计划并促进学术界，工业，国家实验室和技术的科学进步以及 政策职业。

项目成果

Dynamic interfaces for contact-time control of colloidal interactions.

用于胶体相互作用的接触时间控制的动态接口。

• DOI: 10.1039/d3sm00673e
• 发表时间: 2023
• 期刊: Soft matter
• 影响因子: 3.4
• 作者: Xu,Yaxin;Choi,KyuHwan;Nagella,SachitG;Takatori,ShoC
• 通讯作者: Takatori,ShoC

Colloidal transport phenomena in dynamic, pulsating porous materials.

动态脉动多孔材料中的胶体传输现象。

• DOI: 10.1002/aic.18215
• 发表时间: 2023
• 期刊: AIChE journal. American Institute of Chemical Engineers
• 作者: Nagella,SachitG;Takatori,ShoC
• 通讯作者: Takatori,ShoC

Silicone implant surface roughness, friction, and wear

硅胶植入物表面粗糙度、摩擦力和磨损

• DOI: 10.1088/2051-672x/ac9f5a
• 发表时间: 2023
• 期刊: Surface Topography: Metrology and Properties
• 作者: Atkins, Dixon J;Chau, Allison L;Rosas, Jonah M;Chen, Yen-Tsung;Chan, Samantha T;Manuel Urueña, Juan;Pitenis, Angela A
• 通讯作者: Pitenis, Angela A

In vitro models of soft tissue damage by implant-associated frictional shear stresses

植入物相关摩擦剪切应力引起的软组织损伤的体外模型

• DOI: 10.1177/13506501221132897
• 发表时间: 2023
• 期刊: Part J: Journal of Engineering Tribology
• 作者: Rosas, Jonah M.;Atkins, Dixon J.;Chau, Allison L.;Chen, Yen-Tsung;Bae, Rachel;Cavanaugh, Megan K.;Espinosa Lima, Ricardo I.;Bordeos, Andrew;Bryant, Michael G.;Pitenis, Angela A.
• 通讯作者: Pitenis, Angela A.