Predoctoral Training Program in Quantitative Mechanobiology

定量力学生物学博士前培训项目

基本信息

批准号：
10626763
负责人：
Beth L Pruitt
金额：
$ 30.98万
依托单位：
UNIVERSITY OF CALIFORNIA SANTA BARBARA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10626763
关键词：
Training Programs pre-doctoral

项目摘要

Project Summary/Abstract This application seeks funding for a new Interdisciplinary Predoctoral Training Program in Quantitative Mechanobiology at University of California, Santa Barbara (UCSB). The Program brings biologists, physicists, and engineers together to pursue fundamental understanding of the biophysical principles underlying human health spanning molecular to organismal level processes of mechanosignaling in development, homeostasis and disease. The focus of this initiative is cross-disciplinary training in mechanobiology, i.e., relationships between physical forces and biological structure and function, to produce a new cadre of bioscientists who will develop quantitative solutions to biology’s most challenging problems. If funded, the Training Program in Quantitative Mechanobiology will be UCSB’s first training grant and will serve as a flagship predoctoral training program that nucleates a connected community across the many labs already conducting mechanobiology research at UCSB through peer-to-peer interactions, cross-lab training, seminars, courses, and an annual symposium/retreat. The Program will provide support for Fellows to undertake three research rotations in their first year and opportunities for unique cross-training in mechanobiology. Each year, six Mechanobiology Fellows will be admitted with a steady state Program size of twelve predoctoral training slots. The Program will recruit and support Fellows from six graduate degree programs and augment their PhD programs with training in quantitative bioscience methods, engineering models and devices, and multi-disciplinary cross-training to develop and apply quantitative approaches to problems in mechanobiology. To provide optimal interdisciplinary mentorship and research training experiences, each Fellow will work with their project PI and will also be assigned a Program Mentor with complementary seniority, quantitative, experimental, and analytical approaches. The Program Mentor will also serve on the Fellow’s dissertation committee. This chain of mentorship is supported by formal Mentor trainings and leverages our mix of junior and senior Faculty Mentors to support both our Fellows and our junior Faculty Mentors. Fellows will benefit from formalized interactions with the diverse community of faculty and peers, as well as resources, associated with Program and affiliated graduate programs. Key components of the Program include formalized training in Responsible Conduct of Research, Quantitative Experiments, didactic and hands-on training in methods and analytical techniques in a Mechanobiology Methods course and quarterly “open door” lab sessions in Faculty Mentor labs. The Program will feature monthly seminars with peers, visiting researchers, and Faculty Mentors as well as career development activities, and an annual symposium/retreat uniting the entire UCSB mechanobiology community. Trainees from diverse disciplines, backgrounds, and groups will be prepared to lead rigorous biomedical research programs and promote scientific advances in academia, industry, national labs, and technology and policy careers.

项目概要/摘要该申请为新的定量研究跨学科博士前培训项目寻求资金加州大学圣塔芭芭拉分校 (UCSB) 的机械生物学项目吸引了生物学家、物理学家、和工程师一起追求对人类生物物理原理的基本理解发育、稳态中机械信号传导的分子到有机体水平的健康过程该计划的重点是机械生物学（即关系）的跨学科培训。物理力量与生物结构和功能之间的关系，以产生一支新的生物科学家骨干队伍，他们将为定量生物学最具挑战性的问题开发解决方案如果获得资助，培训计划将在定量力学生物学将是加州大学圣巴巴拉分校的第一个培训资助，并将作为旗舰博士前培训该计划在许多已经开展机械生物学的实验室中形成了一个相互联系的社区通过同行互动、跨实验室培训、研讨会、课程和年度研究在 UCSB 进行研究该计划将为研究员进行三轮研究轮换提供支持。第一年和机械生物学独特交叉培训的机会每年有六门机械生物学。研究员将以十二个博士前培训名额的稳定状态项目规模被录取。招募和支持六个研究生学位项目的研究员，并通过培训增强他们的博士项目定量生物科学方法、工程模型和设备以及多学科交叉培训开发并应用定量方法来解决机械生物学问题，提供最佳的跨学科。指导和研究培训经验，每位研究员将与其项目 PI 一起工作，并且还将指定一名具有互补资历、定量、实验和分析能力的项目导师项目导师还将在研究员的论文委员会中任职。导师制由正式的导师培训提供支持，并利用我们的初级和高级教师导师组合支持我们的研究员和初级教师导师将受益于正式的互动。与不同的教师和同行社区以及与计划和隶属关系相关的资源该计划的关键组成部分包括负责任行为的正式培训。研究、定量实验、方法和分析技术的教学和实践培训机械生物学方法课程和教师导师实验室的季度“开放”实验室课程。每月将与同行、访问研究人员、教师导师以及职业导师举行研讨会开发活动，以及联合整个 UCSB 机械生物学界的年度研讨会/务虚会。来自不同学科、背景和群体的学员将准备好领导严格的生物医学研究计划并促进学术界、工业界、国家实验室和技术的科学进步政策职业。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Dynamic interfaces for contact-time control of colloidal interactions.

用于胶体相互作用的接触时间控制的动态接口。

DOI：
10.1039/d3sm00673e
发表时间：
2023
期刊：
Soft matter
影响因子：
3.4
作者：
Xu,Yaxin;Choi,KyuHwan;Nagella,SachitG;Takatori,ShoC
通讯作者：
Takatori,ShoC

In vitro models of soft tissue damage by implant-associated frictional shear stresses

植入物相关摩擦剪切应力引起的软组织损伤的体外模型

DOI：
10.1177/13506501221132897
发表时间：
2023
期刊：
Part J: Journal of Engineering Tribology
影响因子：
0
作者：
Rosas, Jonah M.;Atkins, Dixon J.;Chau, Allison L.;Chen, Yen-Tsung;Bae, Rachel;Cavanaugh, Megan K.;Espinosa Lima, Ricardo I.;Bordeos, Andrew;Bryant, Michael G.;Pitenis, Angela A.
通讯作者：
Pitenis, Angela A.

Silicone implant surface roughness, friction, and wear

硅胶植入物表面粗糙度、摩擦力和磨损

DOI：
10.1088/2051-672x/ac9f5a
发表时间：
2023
期刊：
Surface Topography: Metrology and Properties
影响因子：
0
作者：
Atkins, Dixon J;Chau, Allison L;Rosas, Jonah M;Chen, Yen-Tsung;Chan, Samantha T;Manuel Urueña, Juan;Pitenis, Angela A
通讯作者：
Pitenis, Angela A

Colloidal transport phenomena in dynamic, pulsating porous materials.

动态脉动多孔材料中的胶体传输现象。