A translational human laboratory Pavlovian conditioning model of individual differences in risk for alcohol cue incentive salience sensitization and longitudinal assessment of problematic alcohol use

酒精提示诱因显着性敏感性和有问题的酒精使用的纵向评估风险个体差异的转化人类实验室巴甫洛夫调节模型

• 批准号: 10626730
• 负责人: Roberto U Cofresi
• 金额: $ 16.45万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10626730
• 关键词: Address; Adult; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholic Beverages; Alcoholic Intoxication; Alcohols; Area; Association Learning; Award; Behavioral; Behavioral Mechanisms; Brain; Clinical; Cognitive; Conditioned Reflex; Cues; Dedications; Desire for food; Development; Development Plans; Diagnosis; Disease; Educational workshop; Electroencephalography; Etiology; Event-Related Potentials; Exhibits; Faculty; Functional Magnetic Resonance Imaging; Future; Goals; Heavy Drinking; Heterogeneity; Home; Human; Incentives; Individual; Individual Differences; Institution; Knowledge; Laboratories; Learning; Link; Literature; Measurable; Measures; Mentors; Methods; Mission; Missouri; Modeling; Motivation; National Institute on Alcohol Abuse and Alcoholism; Neurobiology; Nucleus Accumbens; Participant; Pathway interactions; Persons; Phase; Phenotype; Population; Positioning Attribute; Pre-Clinical Model; Prevention; Psychopathology; Public Health; Recording of previous events; Research; Research Personnel; Research Support; Rewards; Role; Sampling; Science; Scientist; Signal Transduction; Smell Perception; Strategic Planning; System; Taste Perception; Testing; Time; Training; Training Programs; Translating; Translations; United States; United States National Institutes of Health; Universities; Variant; Vision; Visit; Visual; Work; addiction; affective neuroscience; alcohol abuse therapy; alcohol cue; alcohol involvement; alcohol related problem; alcohol research; alcohol reward; alcohol risk; alcohol sensitivity; alcohol use disorder; behavioral phenotyping; blood oxygenation level dependent response; career; career development; clinical development; conditioning; craving; cue reactivity; disorder prevention; disorder risk; efficacious treatment; experience; improved; incentive salience; neural circuit; neurobehavioral; neurobiological mechanism; neuroimaging; neurophysiology; peer; post-doctoral training; pre-clinical; preference; programs; psychologic; skills; sugar; symposium; theories; translational neuroscience

PROJECT SUMMARY/ABSTRACT This K99/R00 NIH Pathway to Independence Award will provide Dr. Cofresí, trained as a preclinical neuroscientist, with a two-year intensive, mentored training and research experience in translational neuroscience and three-years of research support that will launch his career as an independent investigator. The training and research program focuses on bidirectional translation between preclinical and human laboratory models of neurobehavioral mechanisms that promote alcohol use disorder (AUD). The K99 career development plan will provide training in AUD psychopathology, human alcohol administration, human cognitive/affective neuroscience, and human functional neuroimaging methods. Training will include coursework, conferences, individualized one-on-one mentoring, seminars, and workshops. The K99 research focuses on a neurobehavioral domain of the Addictions Neuroclinical Assessment believed to be critical to the Addiction/AUD Cycle: the attribution of incentive salience (IS) to alcohol cues. Preclinical and human neurobehavioral evidence suggests that repeated alcohol intoxication can sensitize IS attribution to alcohol cues, which may drive the Addiction/AUD Cycle in some individuals. To begin testing this possibility, Dr. Cofresí will translate a preclinical model of individual differences in propensity to attribute IS to reward- predictive cues into a human laboratory model of individual differences in propensity to attribute IS to alcohol intoxication-predictive vs. natural reward-predictive cues, and examine how these individual differences are associated with future problematic alcohol use. Dr. Cofresí’s development will be facilitated by a team with collective expertise spanning the areas of training (Drs. Bruce Bartholow, Shelly Flagel, Brett Froeliger, David Kareken, Denis McCarthy, Ed Merkle, Thomas Piasecki, Kenneth Sher, Todd Schachtman). The K99 phase will take place at the University of Missouri, a world-class research institution, in the Department of Psychological Sciences, home to renowned faculty in alcohol and addiction research with human participants and a premier alcohol research training program (T32-AA013526). The R00 research will take place at a to-be- determined R1 institution, and will focus on continued testing of IS attribution to alcohol-predictive cues and its sensitization in the human laboratory. This K99/R00 award will produce research that advances Goal 1 Objective 1a of the 2017-2021 NIAAA Strategic Plan, which involves identifying behavioral and neurobiological mechanisms underlying AUD, and explaining heterogeneity in how people progress through the Addiction/AUD Cycle, in order to inform the development of AUD prevention and treatment. This K99/R00 award will also produce an independent scientist able and committed to conducting basic behavioral and neurobiological research with human participants that will continue to advance NIAAA’s mission to improve diagnosis, prevention, and treatment of alcohol-related problems, including AUD.

项目摘要/摘要 这项K99/R00 NIH独立奖将为Cofresí博士提供临床前培训 神经科学家，具有两年的培训和研究经验为期两年 神经科学和三年的研究支持将启动他作为独立研究者的职业。 培训和研究计划的重点是临床前与人之间的双向翻译 促进饮酒障碍（AUD）的神经行为机制的实验室模型。 K99职业 开发计划将提供AUD心理病理学，人类酒精管理，人类的培训 认知/情感神经科学和人类功能神经影像学方法。培训将包括 课程工作，会议，个性化的一对一心理，半手和讲习班。 K99研究 侧重于成瘾的神经行为领域神经临床评估，被认为至关重要 成瘾/aud循环：激励显着性的属性（IS）对酒精提示。临床前和人类 神经行为的证据表明，重复的酒精中毒可能归因于酒精 提示，这可能会驱动某些人的成瘾/aud循环。为了开始测试这种可能性，博士 Cofresí将翻译一个临床前模型的个体差异属性的临床前模型是奖励 - 预测性线索成为人类实验室的个体差异归因于酒精的实验室模型 中毒预测性与自然奖励预测性提示，并检查这些个体差异是如何的 与未来有问题的饮酒有关。 Cofresí博士的发展将由一个团队准备 跨越培训领域的集体专业知识（Bruce Bartholow博士，Shelly Flagel，Brett Froeliger，David Kareken，Denis McCarthy，Ed Merkle，Thomas Piasecki，Kenneth Sher，Todd Schachtman）。 K99阶段 将在密苏里大学（一家世界一流的研究机构）举行。 心理科学，与人类参与者的酒精和成瘾研究著名教师的家园 以及一项主要的酒精研究培训计划（T32-AA013526）。 R00研究将在 确定R1机构，并将集中于继续测试IS的属性 人类实验室的敏化。这项K99/R00奖将产生促进目标1的研究1 2017 - 2021年NIAAA战略计划的目标1A，涉及识别行为和神经生物学 AUD的机制，并解释人们如何通过成瘾/AUD进行异质性 循环，以告知预防和治疗的发展。该K99/R00奖也将 生产独立的科学家可以并致力于进行基本的行为和神经生物学 与人类参与者的研究将继续促进NIAAA提高诊断的使命， 预防和与酒精有关的问题的治疗，包括AUD。