Research Training in Endocrinology and Metabolism

内分泌学和代谢研究培训

• 批准号: 10627311
• 负责人: Laura C Alonso
• 金额: $ 18.95万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627311
• 关键词: Endocrinology; Research Training

PROJECT SUMMARY This proposed postdoctoral training program (2 fellows/year, 2-year program) in endocrinology and metabolism will provide comprehensive research training for individuals with a serious commitment to a career at the interface of biomedical research and endocrine disorders. Metabolic diseases represent significant health burden in the US; advances in the pathophysiology of these diseases are required to improve diagnostics, therapeutics and health outcomes. Weill Cornell Medicine (WCM) is experiencing accelerating growth in clinical and biomedical research activities, due to the singular emphasis on developing medical research over the past decade during the Deanships of Dr. Laurie Glimcher and Dr. Augustine Choi. Investment in the Department of Medicine and the Division of Endocrinology, Diabetes and Metabolism has been significant. Dr. Anthony Hollenberg, a prominent endocrinologist and thyroid biologist, was recruited to Chair the Department of Medicine in 2018; his support has catapulted metabolic research to a high priority on campus, resulting in recruitments and significant internal and external resources. Dr. Laura Alonso, islet biologist and PD on this proposal, was recruited in 2019 to be Chief of the Endocrinology Division and Director of the Weill Center for Metabolic Health, a newly assembled research group on campus focused on metabolism, with 45+ faculty and 150+ members. Our proposed T32 leadership team also includes Dr. Julianne Imperato-McGinley, renowned endocrinologist, prior Division Chief and current Director of the Weill Cornell CTSC. However, the impetus for this proposal is not the leadership team, but rather the incredible trainees that have been finding a path to academic medicine even without T32 support. Three clinical endocrine fellows in the past 10 years managed to obtain K08 awards and are currently leading successful academic research careers, despite the lack of an available T32; one of our current 2nd year fellows elected to pursue a 3rd year of research training even though our program has been advertised as a 2-year clinical program, and both of the incoming clinical fellows for 2022 are outstanding researchers, one with a PhD from Cal Tech and the other with a first author Nature Medicine paper in islet biology, mentored by one of our faculty preceptors (Dr. Lo). We have hand-picked a top team of research Preceptors, and designed a comprehensive didactic training plan with wrap-around mentoring to guide trainees through eventual R01 submission. Our recruitment plan is thorough and has a strong emphasis towards enrolling top URM candidates. We propose a tri- institutional (WCM, MSKCC and RU), rigorous multidisciplinary T32 to enroll 2 postdoctoral MD or PhD trainees annually for 2 years training duration each. The leaders of this training program will work with the utmost enthusiasm and energy to ensure that our trainees reach their potential to excel and contribute significantly to the academic endocrine community for years to come.

项目摘要 该拟议的博士后培训计划（2年/年，2年2年计划）和内分泌学和 代谢将为个人提供全面的研究培训 在生物医学研究和内分泌疾病的界面上的职业。代谢疾病代表 美国的重大健康负担；这些疾病的病理生理学的进步必须 改善诊断，治疗和健康结果。 Weill Cornell Medicine（WCM）正在经历 由于对临床和生物医学研究活动的加速增长，这是由于对 在过去的十年中，在劳里·格林彻（Laurie Glimcher）和博士（Dr. 奥古斯丁·崔（Augustine Choi）。投资医学系和糖尿病的内分泌学系 新陈代谢很重要。著名的内分泌学家和甲状腺Anthony Hollenberg博士 生物学家，于2018年被招募担任医学系主席；他的支持已经弹起了代谢 在校园中高度重视的研究，导致招募以及大量的内部和外部 资源。该提案的伊斯莱特生物学家兼PD劳拉·阿隆索（Laura Alonso）博士于2019年被招募为首席 内分泌科兼威尔代谢健康中心主任，是一个新组装的 校园研究小组的重点是代谢，有45多个教职员工和150多名成员。我们提出的 T32领导团队还包括著名内分泌学家Julianne Imperato-McGinley博士 Weill Cornell CTSC的部门首席兼现任主任。但是，该提议的动力是 不是领导团队，而是一直在寻找通往学术途径的令人难以置信的学员 即使没有T32支持，医学也是如此。过去10年中，三个临床内分泌研究员设法 尽管缺乏 可用的T32;我们目前的第二年研究员之一，即使参加第三年的研究培训 尽管我们的计划已被广告为2年的临床计划，并且两者都传入 2022年的研究员是杰出的研究人员，一个是Cal Tech的博士学位，另一个是第一次 由我们的一位教职员工指导的Islet Biology的作者自然医学论文（Lo博士）。我们 已经手工挑选了一支顶级研究受体团队，并设计了全面的教学培训 与环绕的指导计划，指导受训者最终提交R01。我们的招募 计划是彻底的，并且非常重视参加顶级URM候选人。我们提出了一个三 机构（WCM，MSKCC和RU），严格的多学科T32，以注册2个博士后MD或博士学位 学员每年培训2年。该培训计划的领导者将与 最大的热情和精力，以确保我们的学员发挥出卓越和贡献的潜力 在未来几年中，重要的是学术内分泌社区。