Inflammation Changes Associated with Interoception Changes following Vibroacoustically Augmented Breath Focused Mindfulness for Dissociation

振动声学增强呼吸集中正念解离后与内感受变化相关的炎症变化

• 批准号: 10632723
• 负责人: NEGAR FANI
• 金额: $ 11.13万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10632723
• 关键词: Acute-Phase Proteins; Address; Affect; Amygdaloid structure; Anxiety; Attention; Attentional deficit; Awareness; Biological Assay; Biological Markers; Black American; Blood specimen; Brain; Breathing; C-reactive protein; Characteristics; Chronic; Clinical; Clinical Trials; Complement; Corpus striatum structure; Cues; Data; Devices; Disease; Dissociation; Esthesia; Feedback; Functional Magnetic Resonance Imaging; Glutamates; Goals; Grant; Hippocampus (Brain); Immune response; Immune signaling; Individual; Inflammation; Inflammatory; Inflammatory Response; Insula of Reil; Interleukin-1; Interleukin-1 beta; Interleukin-6; Interoception; Intervention; Link; Measures; Mechanoreceptors; Meditation; Mental Depression; Mind-Body Intervention; Molecular; Necrosis; Neuronal Plasticity; Participant; Pathway interactions; Patient Self-Report; Patients; Pattern; Persons; Physiological; Plasma; Play; Post-Traumatic Stress Disorders; Prefrontal Cortex; Process; Randomized Controlled Trials; Recovery; Research; Resources; Respiration; Role; Signal Transduction; Stimulus; Stress; Symptoms; TNF gene; Time; Trauma; Trust; Viscera; Visceral Afferents; Woman; attentional control; base; clinically significant; cytokine; design; emotion regulation; experience; experimental study; group intervention; immune activation; inflammatory marker; mindfulness; mindfulness intervention; mindfulness meditation; negative affect; neural network; neuromechanism; novel; post intervention; receptor; recruit; response; stress related disorder; sustained attention; systematic review; trauma exposure; tumor; vibration

Dissociation is a multifaceted, transdiagnostic, and disabling phenomenon that involves detachment from the self or surroundings. It is prevalent in trauma-exposed people with posttraumatic stress disorder, occurs in other disorders (e.g., depression, anxiety), and is a barrier to recovery in first-line treatments. Dissociation is characterized by disruptions in body awareness, or interoception, and some research suggests that highly dissociative individuals also have higher inflammatory tone. Mindfulness-based meditative practices, including breath- focused mindfulness meditation (BFM), are designed to enhance interoceptive awareness to physiological signals (breath) and are also shown to reduce inflammation. However, mindfulness is often a difficult task for dissociative people, who experience disruptions in body agency and are unable to access or trust body signals. Exteroceptive feedback enhances interoceptive awareness and body agency in experimental studies and may similarly facilitate changes in inflammation in conjunction with mindfulness interventions. As such, the goal of this supplement is to examine potential changes in inflammation with changes in interoception in dissociative traumatized patients via BFM augmented with exteroceptive feedback. This is delivered by a unique device that vibrates in concert with respiration, yielding non-ignorable mechanoreceptor reactivity to breathing. Using a stimulus-driven mechanism, our device is expected to enhance body agency and efficiently engage attention and interoception networks. We will recruit 45 trauma-exposed people with clinically significant dissociation symptoms, divided in four equal groups to yield a 2x2 (BFM or non-judgmental awareness x with or without vibroacoustic stimulation) design. All participants attend 8 sessions of their assigned intervention. We will collect blood samples for inflammatory assays pre and post-intervention (2 time points) to examine change in inflammation with interoception, measured clinically as well as during an interoception task during fMRI pre- and post-intervention. We will examine: Aim 1) whether changes in inflammatory markers, including c-reactive protein, interleukin-1 and -6, and tumor necrosis α, are significant from pre- to post intervention; Aim 2) whether changes in inflammatory markers are associated with change in interoception (measured clinically and via neural network response), and whether BFM with exteroceptive feedback significantly moderates these changes; Aim 3) whether change in inflammation is associated with change in dissociation, and whether BFM with exteroceptive feedback significantly moderates these changes.

解离是一种多方面的，经诊断的和禁用的现象，涉及 脱离自我或周围环境。它在暴露于创伤的人中很普遍 创伤后应激障碍，发生在其他疾病（例如抑郁症，动画）中，是一个 一线治疗中恢复的障碍。解离的特征是身体中断 意识或感受，一些研究表明，高度分离的个体 也具有较高的炎症语调。基于正念的冥想做法，包括呼吸 专注的正念冥想（BFM）旨在提高感知性的意识 物理信号（呼吸），也证明可以减少炎症。然而， 对于分离的人来说，正念通常是一项艰巨的任务，他们在身体中遇到干扰 代理商，无法访问或信任身体信号。外部感受反馈增强 实验研究中的感受意识和身体代理，并可能同样支持 与正念干预结合使用炎症的变化。因此，目标的目标 补充是检查炎症的潜在变化，随着截距的变化 通过BFM扩大反馈，通过BFM增加了解离性创伤患者。这是 由独特的设备交付，该设备与呼吸协同振动，产生不可忽视的 机理感受器对呼吸的反应性。使用刺激驱动的机制，我们的设备是 有望增强人体代理并有效地致力于关注和拦截网络。 我们将招募45名患有临床显着解离症状的暴露于创伤的人， 分为四个相等的组以产生2x2（有或没有的，bfm或非判断性意识x 振动声刺激）设计。所有参与者参加了8个会议 干涉。我们将收集血液样本以进行干预前和干预后的炎症测定（2 时间点）以检查截距的炎症变化，也可以在临床上测量 就像在干预前和干预后的拦截任务中一样。我们将检查：目标1） 炎症标记的变化是否包括C反应蛋白，白介素1和-6，以及 肿瘤坏死α从干预前到干预很重要。目标2）是否改变 炎症标记与截距的变化有关（临床和通过 神经网络响应），以及带有扩展反馈的BFM是否显着 调节这些更改；目标3）炎症的变化是否与变化有关 解离，以及与扩展反馈的BFM是否显着缓和了这些 更改。