Facility and Building System Upgrades Support for the Howard T. Ricketts Biocontainment Laboratory

为 Howard T. Ricketts 生物防护实验室提供设施和建筑系统升级支持

• 批准号: 10631368
• 负责人: Erin June Adams
• 金额: $ 329.34万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-16 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631368
• 关键词: 2019-nCoV; Administrative Supplement; Affect; Age; Air; Animal Model; Animals; Anthrax disease; Architecture; Area; Atlases; Automation; Bacillus; Bacillus anthracis; Basic Science; Biometry; Brucella; Bulla; Carbon Dioxide; Carpet; Cavia; Centers for Disease Control and Prevention (U.S.); Chicago; Client; Computer Security; Computer software; Computers; Consumption; Contract Services; County; Coxiella; Custom; DNA; Department of Energy; Development; Devices; ESKAPE pathogens; Electrophoresis; Ensure; Equipment; Excision; Facility Construction; Failure; Farm; Filler; Freezing; Goals; Hamsters; High Pressure Liquid Chromatography; House mice; Illinois; Immunology; Incubators; Individual; Industrialization; Infectious Agent; Influenza; Institution; Investigation; Laboratories; Life; Lighting; Location; Longevity; Maintenance; Manufacturer Name; Maps; Membrane; Microbiology; Microscope; Modeling; Molecular Biology; Monitor; Motor; Mus; Oils; Operations Research; Organism; Panthera leo; Pathogenicity; Persons; Plague; Polyesters; Price; Procedures; Process; Proteins; Rattus; Reader; Regulation; Research; Research Support; Rickettsia; Risk Assessment; Rodent; Running; Safety; Scientist; Security; Series; Services; Site; Sodium; Source; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry; Speed; Stains; Stretching; Students; Surveillance Program; Swelling; System; Technology; Temperature; Testing; Textiles; Thick; Time; Training Programs; Universities; Urethane; Vacuum; Vacuum Pumps; Water; Woman; Work; Yersinia; Yersinia pestis; air filter; biosecurity; cost; emerging pathogen; exhaust; experimental study; hazard; high efficiency particulate air filter; imaging system; instrument; laboratory experiment; mass spectrometer; meetings; men; methicillin resistant Staphylococcus aureus; model design; motor control; new technology; novel therapeutics; novel vaccines; operation; pathogen; pathogenic virus; preservation; pressure; pressure sensor; programs; purge; repaired; research facility; response; restoration; seal; sensor; tissue culture; vapor

Project Summary/Abstract The Howard Taylor Ricketts Laboratory (HTRL) is a state-of-the-art Regional Biocontainment Laboratory on the Argonne National Laboratory (ANL) campus in DuPage County, Illinois. Located twenty-five miles southwest from the University of Chicago campus, ANL is a federally (Department of Energy) owned site operated by the University of Chicago (UCHICAGO LLC). HTRL is a CDC certified facility owned by the University of Chicago and operated by the Department of Microbiology. Biosafety training and surveillance program involving classroom and laboratory activities ensures that staff, students, and fellows comply with state and federal regulations to safely operate facilities and experiments with RG2, RG3 and Select Agent pathogens. The HTRL construction was completed in 2008. Over the last 13 years, the HTRL has hosted research programs studying the bacterial species Yersinia, Brucella, Coxiella, Rickettsia, Bacilli, MRSA and other ESKAPE organisms, as well as viral pathogens including low and highly pathogenic influenza, DENGUE and more recently SARS- CoV2. The facility currently hosts research program on Plague, Anthrax, MRSA, as well as a Core Research Facility for SARS-CoV2. The HTRL is the largest A-BSL3 holding facility in the region and regularly supports research from consortium institutions including UIC, Northwestern U and Loyola U. The HTRL is fulfilling its goal to rapidly respond to research needs and support biomedical inquiries on emerging and re-emerging pathogens, discovery and testing of new therapeutics and vaccines. The building has been maintained in good working conditions and has been in constant use since its construction. However, with the swelling demands for BSL3 and ABSL3 space and research expertise, the development of new technologies for the study of infectious agents, this proposal is a request (i) to upgrade system and building components for safe research operations, and (ii) to replace research equipment that have either outlived the intended useful life or no longer meet facility requirements.

项目概要/摘要 霍华德·泰勒·里基茨实验室 (HTRL) 是一个最先进的区域性实验室 杜佩奇阿贡国家实验室 (ANL) 园区的生物防护实验室 伊利诺伊州县。位于芝加哥大学校园西南二十五英里处， ANL 是联邦政府（能源部）所有的站点，由芝加哥大学运营 （芝加哥有限责任公司）。 HTRL 是芝加哥大学拥有的 CDC 认证机构 由微生物学系负责管理。生物安全培训和监测计划 涉及课堂和实验室活动，确保教职员工、学生和研究员遵守规定 符合州和联邦法规，安全运行 RG2、RG3 设施和实验 并选择代理病原体。 HTRL 建设于 2008 年完成。过去 13 年 多年来，HTRL 主持了研究耶尔森氏菌的研究项目， 布鲁氏菌、柯克斯体、立克次体、杆菌、MRSA 和其他 ESKAPE 生物体以及病毒 病原体包括低致病性和高致病性流感、登革热以及最近的 SARS- 冠状病毒2。该设施目前主持鼠疫、炭疽、MRSA 以及一个 SARS-CoV2 核心研究设施。 HTRL 是全球最大的 A-BSL3 持有设施 地区并定期支持包括 UIC、西北大学在内的财团机构的研究 U 和 Loyola U。HTRL 正在实现快速响应研究需求和支持的目标 对新出现和重新出现的病原体的生物医学调查、新病原体的发现和测试 疗法和疫苗。该建筑一直保持良好的工作条件 自建成以来一直在不断使用。然而，随着 BSL3 需求的不断增长 和ABSL3空间和研究专业知识，开发用于研究的新技术 传染性病原体，该提案是要求（i）升级系统和建筑组件 安全的研究操作，以及 (ii) 更换已经过时的研究设备 预期使用寿命或不再满足设施要求。