Facility and Building System Upgrades Support for the Howard T. Ricketts Biocontainment Laboratory

为 Howard T. Ricketts 生物防护实验室提供设施和建筑系统升级支持

• 批准号: 10631368
• 负责人: Erin June Adams
• 金额: $ 329.34万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-16 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631368
• 关键词: 2019-nCoV; Administrative Supplement; Affect; Age; Air; Animal Model; Animals; Anthrax disease; Architecture; Area; Atlases; Automation; Bacillus; Bacillus anthracis; Basic Science; Biometry; Brucella; Bulla; Carbon Dioxide; Carpet; Cavia; Centers for Disease Control and Prevention (U.S.); Chicago; Client; Computer Security; Computer software; Computers; Consumption; Contract Services; County; Coxiella; Custom; DNA; Department of Energy; Development; Devices; ESKAPE pathogens; Electrophoresis; Ensure; Equipment; Excision; Facility Construction; Failure; Farm; Filler; Freezing; Goals; Hamsters; High Pressure Liquid Chromatography; House mice; Illinois; Immunology; Incubators; Individual; Industrialization; Infectious Agent; Influenza; Institution; Investigation; Laboratories; Life; Lighting; Location; Longevity; Maintenance; Manufacturer Name; Maps; Membrane; Microbiology; Microscope; Modeling; Molecular Biology; Monitor; Motor; Mus; Oils; Operations Research; Organism; Panthera leo; Pathogenicity; Persons; Plague; Polyesters; Price; Procedures; Process; Proteins; Rattus; Reader; Regulation; Research; Research Support; Rickettsia; Risk Assessment; Rodent; Running; Safety; Scientist; Security; Series; Services; Site; Sodium; Source; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry; Speed; Stains; Stretching; Students; Surveillance Program; Swelling; System; Technology; Temperature; Testing; Textiles; Thick; Time; Training Programs; Universities; Urethane; Vacuum; Vacuum Pumps; Water; Woman; Work; Yersinia; Yersinia pestis; air filter; biosecurity; cost; emerging pathogen; exhaust; experimental study; hazard; high efficiency particulate air filter; imaging system; instrument; laboratory experiment; mass spectrometer; meetings; men; methicillin resistant Staphylococcus aureus; model design; motor control; new technology; novel therapeutics; novel vaccines; operation; pathogen; pathogenic virus; preservation; pressure; pressure sensor; programs; purge; repaired; research facility; response; restoration; seal; sensor; tissue culture; vapor

Project Summary/Abstract The Howard Taylor Ricketts Laboratory (HTRL) is a state-of-the-art Regional Biocontainment Laboratory on the Argonne National Laboratory (ANL) campus in DuPage County, Illinois. Located twenty-five miles southwest from the University of Chicago campus, ANL is a federally (Department of Energy) owned site operated by the University of Chicago (UCHICAGO LLC). HTRL is a CDC certified facility owned by the University of Chicago and operated by the Department of Microbiology. Biosafety training and surveillance program involving classroom and laboratory activities ensures that staff, students, and fellows comply with state and federal regulations to safely operate facilities and experiments with RG2, RG3 and Select Agent pathogens. The HTRL construction was completed in 2008. Over the last 13 years, the HTRL has hosted research programs studying the bacterial species Yersinia, Brucella, Coxiella, Rickettsia, Bacilli, MRSA and other ESKAPE organisms, as well as viral pathogens including low and highly pathogenic influenza, DENGUE and more recently SARS- CoV2. The facility currently hosts research program on Plague, Anthrax, MRSA, as well as a Core Research Facility for SARS-CoV2. The HTRL is the largest A-BSL3 holding facility in the region and regularly supports research from consortium institutions including UIC, Northwestern U and Loyola U. The HTRL is fulfilling its goal to rapidly respond to research needs and support biomedical inquiries on emerging and re-emerging pathogens, discovery and testing of new therapeutics and vaccines. The building has been maintained in good working conditions and has been in constant use since its construction. However, with the swelling demands for BSL3 and ABSL3 space and research expertise, the development of new technologies for the study of infectious agents, this proposal is a request (i) to upgrade system and building components for safe research operations, and (ii) to replace research equipment that have either outlived the intended useful life or no longer meet facility requirements.

项目摘要/摘要 霍华德·泰勒（Howard Taylor Ricketts）实验室（HTRL）是最先进的区域性 阿尔贡国家实验室（ANL）校园的生物疗养实验室 伊利诺伊州县。距芝加哥大学校园西南25英里， ANL是芝加哥大学经营的联邦政府（能源部）拥有的地点 （Uchicago LLC）。 HTRL是芝加哥大学拥有的CDC认证设施， 由微生物学系运营。生物安全培训和监视计划 涉及课堂和实验室活动可确保员工，学生和研究员遵守 通过州和联邦法规，可以安全地使用RG2，RG3进行设施和实验 并选择药物病原体。 HTRL建筑于2008年完成。 多年来，HTRL托管了研究细菌物种Yersinia的研究计划， 布鲁氏菌，柯西氏菌，立克，细菌，MRSA和其他Eskape生物以及病毒 病原体，包括低和高度致病的流感，登革热和最近的SARS- COV2。该设施目前主持有关瘟疫，炭疽，MRSA的研究计划以及 SARS-COV2的核心研究机构。 HTRL是最大的A-BSL3持有设施 地区并定期支持联盟机构的研究，包括UIC，西北部 U和Loyola U. HTRL正在实现其目标，以快速响应研究需求和支持 关于新兴和重新出现病原体，新发现和测试的生物医学查询 治疗和疫苗。该建筑物一直保持在良好的工作条件下 自构建以来，一直在不断使用。但是，随着BSL3的肿胀需求 以及ABSL3空间和研究专业知识，开发新技术以进行研究 感染者，该建议是升级系统和建造组件的请求（i） 安全的研究操作，以及（ii）取代已经超过的研究设备 预期有用的生活或不再满足设施的要求。