Facility and Building System Upgrades Support for the Howard T. Ricketts Biocontainment Laboratory

为 Howard T. Ricketts 生物防护实验室提供设施和建筑系统升级支持

• 批准号: 10394614
• 负责人: Erin June Adams
• 金额: $ 329.97万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-16 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10394614
• 关键词: 2019-nCoV; Anthrax disease; Bacillus; Biomedical Research; Brucella; Centers for Disease Control and Prevention (U.S.); Chicago; County; Coxiella; Department of Energy; Development; ESKAPE pathogens; Ensure; Equipment; Goals; Humidity; Illinois; Infectious Agent; Influenza; Institution; Laboratories; Life; Microbiology; Operations Research; Organism; Pathogenicity; Plague; Regulation; Research; Research Support; Rickettsia; Site; Students; Surveillance Program; Swelling; System; Temperature; Testing; Training Programs; Universities; Yersinia; emerging pathogen; experimental study; laboratory experiment; methicillin resistant Staphylococcus aureus; new technology; novel therapeutics; novel vaccines; pathogen; pathogenic virus; pressure; programs; research facility

Project Summary/Abstract The Howard Taylor Ricketts Laboratory (HTRL) is a state-of-the-art Regional Biocontainment Laboratory on the Argonne National Laboratory (ANL) campus in DuPage County, Illinois. Located twenty-five miles southwest from the University of Chicago campus, ANL is a federally (Department of Energy) owned site operated by the University of Chicago (UCHICAGO LLC). HTRL is a CDC certified facility owned by the University of Chicago and operated by the Department of Microbiology. Biosafety training and surveillance program involving classroom and laboratory activities ensures that staff, students and fellows comply with state and federal regulations to safely operate facilities and experiments with RG2, RG3 and Select Agent pathogens. The HTRL construction was completed in 2008. Over the last 13 years, the HTRL has hosted research programs studying the bacterial species Yersinia, Brucella, Coxiella, Rickettsia, Bacilli, MRSA and other ESKAPE organisms, as well as viral pathogens including low and highly pathogenic influenza, DENGUE and more recently SARS-CoV2. The facility currently hosts research program on Plague, Anthrax and MRSA, as well as a Core Research Facility for SARS-CoV2. The HTRL is the largest A-BSL3 holding facility in the region and regularly supports research from consortium institutions including UIC, Northwestern U and Loyola U. The HTRL is fulfilling its goal as a biomedical research facility that can rapidly respond to research needs and support biomedical research on emerging and re-emerging pathogens, discovery and testing of new therapeutics and vaccines. The building has been maintained in excellent working conditions and has been in constant use since its construction. However, with the swelling demands for BSL3 and ABSL3 space and research expertise, the development of new technologies for the study of infectious agents, this proposal is a request (i) to upgrade system components necessary to maintain biocontainment, temperature/humidity/pressurization requirements, and safe research operations, and (ii) to replace research equipment that have either outlived the intended useful life or no longer meet facility requirements.

项目摘要/摘要 霍华德·泰勒（Howard Taylor）实验室（HTRL）是最先进 伊利诺伊州杜佩奇县Argonne国家实验室（ANL）校园的实验室。 ANL位于距芝加哥大学校园西南25英里处，是联邦政府 （能源部）由芝加哥大学（Uchicago LLC）经营的地点。 HTRL是芝加哥大学拥有的CDC认证设施，由 微生物学系。涉及教室的生物安全培训和监视计划 和实验室活动可确保员工，学生和研究员遵守州和联邦 使用RG2，RG3和Select Agent安全操作设施和实验的法规 病原体。 HTRL建筑于2008年完成。在过去的13年中，HTRL 已经托管了研究细菌物种Yersinia，Brucella，Coxiella， 立克，细菌，MRSA和其他Eskape生物以及病毒病原体在内 低和高度致病的流感，登革热和最近的SARS-COV2。设施 目前主持有关瘟疫，炭疽和MRSA的研究计划，以及核心研究 SARS-COV2的设施。 HTRL是该地区最大的A-BSL3持有设施， 定期支持来自UIC，UIC，西北U和 Loyola U. Htrl正在实现其作为生物医学研究机构的目标 响应研究需求并支持有关新兴和重新出现的生物医学研究 病原体，新疗法和疫苗的发现和测试。该建筑物已经 保持在良好的工作条件下，自建造以来一直在不断使用。 但是，随着对BSL3和ABSL3空间和研究专业知识的肿胀需求， 开发用于研究传染病药物的新技术，该提议是一个请求（i） 升级维持生物疗法所需的系统组件， 温度/湿度/加压要求和安全的研究操作，以及（ii） 更换已经超过预期使用寿命或不再满足的研究设备 设施要求。