Intensive longitudinal study of suicidal behaviors and related health outcomes

对自杀行为和相关健康结果的深入纵向研究

• 批准号: 10629711
• 负责人: MATTHEW K NOCK
• 金额: $ 16.9万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-22 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10629711
• 关键词: Accelerometer; Address; Adolescent; Adult; Alcohol consumption; Behavior; Cause of Death; Cellular Phone; Data; Data Sources; Devices; Eating Disorders; Ethics; Feeling suicidal; Gastritis; Health; Health behavior; Hospitals; Longitudinal Studies; Maps; Monitor; Nature; Outcome; Persons; Phenotype; Prevention; Problem behavior; Property; Psychiatric Hospitals; Research; Research Personnel; Risk; Sampling; Science; Scientist; Suicide; Suicide attempt; Suicide prevention; Surveys; Technology; Time; Tuberculosis; data communication; data streams; digital; high risk; improved; influenza pneumonia; recruit; substance use; suicidal behavior; suicidal risk; suicide rate; time use; virtual; wearable sensor technology

PROJECT SUMMARY/ABSTRACT Many leading causes of death have declined significantly over the past 100 years (e.g., tuberculosis, pneumonia/influenza, gastritis); however, the suicide rate is virtually identical to what it was 100 years ago. Lack of progress in the prevention of suicide is due in large part to the limited understanding of this problem. Suicidal thoughts and behaviors (STBs), like other behavior problems (e.g., alcohol use, substance use, eating disorders), rarely occur in the research lab where they can be carefully probed and cannot be ethically induced in the lab. As a result, experts lack a firm understanding of the fundamental properties of STBs, and of how, why, and when they unfold in nature. The purpose of this study is to address this enormous gap by using newly developed smartphone and wearable biosensor technologies to conduct an intensive longitudinal study that will advance the understanding and prediction of STBs and related behaviors. This study will monitor 600 people (300 adults and 300 adolescents) at elevated risk of STBs (i.e., those presenting to a psychiatric hospital with suicide ideation and/or a recent suicide attempt) during a high risk time period (i.e., post-hospitalization). The first aim of this study is to identify digital phenotypes of STBs using data collected both actively/subjectively using repeated smartphone surveys and passively/objectively using continuous data from smartphones (e.g., GPS, accelerometer, communications data) and wearable biosensors (e.g., electrodermal activity, accelerometer). The second aim is to map the dynamic trajectories of STBs over time. The third aim is to identify short-term predictors of STBs during the 6 months post-hospital discharge. Ongoing research by the proposed team demonstrates the feasibility of: recruiting and retaining the proposed samples, intensively monitoring them over time using digital devices, and using analyses of these rich data streams to make discoveries about how STBs and related behaviors unfold in nature. The data collected in this study will provide a rich data source that will be used by our research team and collaborative researchers to advance the understanding, prediction, and ultimate prevention of STBs and related outcomes.

项目摘要/摘要 在过去的100年中，许多主要的死亡原因大幅下降（例如结核病， 肺炎/流感，胃炎）；但是，自杀率实际上与100年前的自杀率相同。缺少 预防自杀的进展很大程度上是由于对该问题的有限理解。自杀 思想和行为（STB），例如其他行为问题（例如，饮酒，用途，饮食 疾病），很少发生在研究实验室中，可以仔细探测它们，并且不能在道德上诱导 在实验室。结果，专家缺乏对STB的基本属性以及如何，为什么，为什么， 当它们在自然界中展开时。这项研究的目的是通过新的 开发了智能手机和可穿戴生物传感器技术，以进行深入的纵向研究 提高对STB和相关行为的理解和预测。这项研究将监视600人 （300名成年人和300名青少年），STB的风险较高（即，那些与患有精神病医院的医院 在高风险时期（即院后化），自杀念头和/或最近的自杀企图）。这 这项研究的第一个目的是使用积极/主观地收集的数据来识别STB的数字表型 重复使用智能手机的连续数据（例如GPS， 加速度计，通信数据）和可穿戴生物传感器（例如，电压，加速度计）。 第二个目的是绘制随着时间的推移的动态轨迹。第三个目的是确定短期 在院后6个月内，STB的预测因素。拟议团队正在进行的研究 证明了：招募和保留提议的样本的可行性，并深入监视它们 时间使用数字设备，并使用这些丰富数据流的分析来发现有关STB的方式 和相关的行为在本质上展现出来。本研究中收集的数据将提供丰富的数据源 我们的研究团队和合作研究人员使用来提高理解，预测和最终 预防STB和相关结果。

项目成果

Practices for monitoring and responding to incoming data on self-injurious thoughts and behaviors in intensive longitudinal studies: A systematic review.

• DOI: 10.1016/j.cpr.2021.102098
• 发表时间: 2021-12
• 期刊: Clinical psychology review
• 影响因子: 12.8
• 作者: Bentley KH;Maimone JS;Kilbury EN;Tate MS;Wisniewski H;Levine MT;Roberg R;Torous JB;Nock MK;Kleiman EM
• 通讯作者: Kleiman EM

Intervening on high-risk responses during ecological momentary assessment of suicidal thoughts: Is there an effect on study data?

在自杀念头的生态瞬时评估过程中对高风险反应进行干预：对研究数据有影响吗？

• DOI: 10.1037/pas0001288
• 发表时间: 2024
• 期刊: Psychological assessment
• 影响因子: 3.6
• 作者: Bentley,KateH;Millner,AlexanderJ;Bear,Adam;Follet,Lia;Fortgang,RebeccaG;Zuromski,KellyL;Kleiman,EvanM;Coppersmith,DanielDL;Castro-Ramirez,Franchesca;Millgram,Yael;Haim,Adam;Bird,SuzanneA;Nock,MatthewK
• 通讯作者: Nock,MatthewK

Negative affect is more strongly associated with suicidal thinking among suicidal patients with borderline personality disorder than those without.

• DOI: 10.1016/j.jpsychires.2018.08.006
• 发表时间: 2018-09
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Mou D;Kleiman EM;Fedor S;Beck S;Huffman JC;Nock MK
• 通讯作者: Nock MK

Consensus Statement on Ethical & Safety Practices for Conducting Digital Monitoring Studies with People at Risk of Suicide and Related Behaviors.

• DOI: 10.1176/appi.prcp.20200029
• 发表时间: 2021
• 期刊: Psychiatric research and clinical practice
• 作者: Nock MK;Kleiman EM;Abraham M;Bentley KH;Brent DA;Buonopane RJ;Castro-Ramirez F;Cha CB;Dempsey W;Draper J;Glenn CR;Harkavy-Friedman J;Hollander MR;Huffman JC;Lee HIS;Millner AJ;Mou D;Onnela JP;Picard RW;Quay HM;Rankin O;Sewards S;Torous J;Wheelis J;Whiteside U;Siegel G;Ordóñez AE;Pearson JL
• 通讯作者: Pearson JL

Quantification of acceleration as activity counts in ActiGraph wearable.

• DOI: 10.1038/s41598-022-16003-x
• 发表时间: 2022-07-13
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Neishabouri, Ali;Nguyen, Joe;Samuelsson, John;Guthrie, Tyler;Biggs, Matt;Wyatt, Jeremy;Cross, Doug;Karas, Marta;Migueles, Jairo H.;Khan, Sheraz;Guo, Christine C.
• 通讯作者: Guo, Christine C.