R35 Administrative Supplements to Recognize Excellencein Diversity, Equity, Inclusion, and Accessibility (DEIA)Mentorship

R35 表彰多元化、公平、包容性和可及性 (DEIA) 指导方面卓越表现的行政补充

• 批准号: 10630461
• 负责人: Eva S. Nozik
• 金额: $ 5.17万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630461
• 关键词: Administrative Supplement; Adult; Biomedical Research; Birth; Blood Circulation; Blood Vessels; Chronic; Colorado; Development; Development Plans; Doctor of Philosophy; Exercise; Fetal Liver; Foundations; Hypoxia; Impairment; Individual; Lead; Lung; Medical; Mentorship; Modeling; Mus; Neonatal; Oxidation-Reduction; Phenotype; Physiology; Pregnancy; Publishing; Pulmonary Hypertension; Rattus; Regulation; Research; Research Support; Role; Signal Transduction; Students; Superoxide Dismutase; United States National Institutes of Health; Universities; Work; antioxidant enzyme; base; career development; disadvantaged background; diversity and equity; doctoral student; extracellular; graduate student; hypoxia-induced pulmonary hypertension; interest; macrophage; mouse model; neonatal mice; neonatal pulmonary hypertension; offspring; pre-doctoral; pregnant; prenatal; programs; pulmonary vascular disorder; pup; young adult

Abstract This is a request for an administrative supplement to R35 HL139726 SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases to increase diversity, equity and inclusion in biomedical research by supporting pre-doctoral student, Thi-Tina Nguyen. Thi-Tina Nguyen is a predoctoral student in the Integrative Physiology Graduate Program at the University of Colorado Anschutz Medical Campus and will be joining the Nozik lab in July 2022 for her PhD thesis work. She meets criteria for this program based on being from a disadvantaged background according to the NIH criteria. Ms Nguyen has identified an interest in studying how maternal factors that impair EC-SOD expression lead to dysregulated redox signaling in the lung and pulmonary vasculature of the offspring. Specifically, she plans to build upon the lab's published observations that 1) insufficient EC-SOD (SOD3) worsens neonatal lung and vascular development in neonatal mouse models, as well as chronic hypoxic pulmonary hypertension in adult mice; 2) prenatal hypoxic exposure of pregnant rats reduced pup lung EC-SOD content; 3) exercise increases placental derived EC-SOD in the maternal circulation and protects the fetal liver; and 3) low EC-SOD content modulates macrophage reprogramming in pulmonary vascular diseases. Based on these observations, Ms Nguyen has developed a research plan to investigate how hypoxia in late gestation impacts lung EC-SOD, lung and pulmonary vascular development and macrophage phenotype in the offspring after birth and into young adulthood. This work will provide a foundation for an individual F31 application to expand upon this work. The proposal outlines both the scientific proposal and a summary of the career development plan for Ms. Nguyen.

抽象的 这是向R35 HL139726 SOD3氧化还原调节的管理补充的要求 肺血管疾病中的敏感信号传导增加多样性，公平性和包容性 生物医学研究通过支持博士前的学生Thi-Tina Nguyen。 Thi-tina nguyen是 大学综合生理学研究生课程的研究生课程 科罗拉多州ANSCHUTZ医疗校园，将于2022年7月加入NOZIK实验室 论文工作。她符合该计划的标准，因为 背景根据NIH标准。 Nguyen女士已经确定了研究如何 损害EC-SOD表达的母体因素导致氧化还原信号失调 后代的肺和肺脉管系统。特别是，她计划在实验室的基础上建立 发表的观察结果：1）EC-SOD不足（SOD3）会恶化新生儿肺和血管 新生小鼠模型以及慢性低氧肺动脉高压的发展 成年小鼠； 2）怀孕大鼠产前低氧暴露减少幼犬肺EC-SOD含量； 3） 运动增加了母体循环中的胎盘衍生的EC-SOD并保护胎儿 肝; 3）低EC-SOD含量调节肺血管中的巨噬细胞重编程 疾病。基于这些观察，Nguyen女士制定了一项研究计划 研究妊娠晚期缺氧如何影响肺EC-SOD，肺和肺血管 出生后和成年后后代的发育和巨噬细胞表型。 这项工作将为单个F31应用程序提供基础，以扩展这项工作。 该提案既概述了科学提案，又概述了职业发展的摘要 Nguyen女士的计划。