HAWAII CLINICAL RESEARCH NETWORK FOR HEALTH EQUITY

夏威夷健康公平临床研究网络

• 批准号: 10631836
• 负责人: Venkataraman Balaraman
• 金额: $ 152.18万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-24 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10631836
• 关键词: Address; Adherence; Age; Cerebrovascular Disorders; Chronic Kidney Failure; Clinic; Clinical Research; Communities; Data; Databases; Development; Diabetes Mellitus; Disease; Disease Management; Early Diagnosis; Electronic Health Record; Enrollment; Ensure; Ethnic group; Fatty Liver; Fatty acid glycerol esters; Federally Qualified Health Center; Filipino; General Population; Geography; Goals; Grant; Guidelines; HIV; Hawaii; Health; Health Disparities Research; Health system; Homelessness; Indigenous; Infrastructure; Institutional Review Boards; Island; Link; Liver; Liver Fibrosis; Liver diseases; Logistics; Longevity; Malignant neoplasm of lung; Monitor; Native Hawaiian; Obesity; Pacific Islander; Pacific Ocean; Patients; Persons; Phase; Pilot Projects; Policies; Population; Preparation; Prevalence; Primary Health Care; Procedures; Process; Protocols documentation; Public Health; Registries; Research; Research Design; Research Personnel; Research Project Grants; Risk; Rural Community; Secure; Sexual and Gender Minorities; System; Translational Research; Underinsured; Uninsured; Update; Vulnerable Populations; base; chronic liver disease; clinical research site; comorbidity; data enclave; data repository; elastography; fatty liver disease; gender minority group; health care delivery; health disparity; health equity; interest; malignant breast neoplasm; medically underserved population; non-alcoholic fatty liver disease; patient safety; population based; primary care setting; racial diversity; recruit

Project Summary/Abstract The overall goal of this application is to organize a local consortia of ambulatory primary care settings in Hawaii to form the Hawaii Clinical Research Network for Health Equity (HICRN-HE). The clinical research network will focus on the health disparity needs of the Indigenous Pacific People (IPP)–defined as Native Hawaiians, other Pacific Islanders, and Filipinos. The 2 largest health systems in Hawaii providing primary care to a substantial number of IPP [the Queen’s Health System (QHS) and Hawaii Pacific Health (HPH)] and Federally Qualified Health Centers on Oahu will be invited to join the HICRN-HE. The UG3 (first 2 years of the grant) phase will be devoted to developing the infrastructure for HICRN-HE. A secure analyzable and regularly updated patient data repository derived from electronic health records from QHS and HPH will be established to support database analyses of health disparity issues. A Clinical and Translational Research Registry will be created and maintained to link interested local researchers and their research capabilities with those seeking researchers for clinical research/trials. The HICRN-HE will develop a framework for monitoring the implementation phase of HICRN-HE clinical studies to ensure patient safety, adherence to study protocol, and ability to meet recruitment goals. The UH3 phase (years 3-5 of the grant) will be devoted to implementing 2 projects under the thematic health disparity problem of Non-Alcoholic Fatty Liver Disease (NAFLD). Project 1 will focus on NAFLD over the Lifespan in Hawaii and assess the prevalence, risk, co-morbidities, and age at onset of NAFLD in IPP. Project 2 will focus on rates and risks of NAFLD among our sexual and gender minority groups living with HIV to uncover the HIV-specific factors that may contribute to risk above and beyond those in the general population.

项目摘要/摘要 该申请的总体目标是在夏威夷组织一个当地的门诊初级保健环境财团 形成夏威夷卫生平等临床研究网络（Hicrn-He）。临床研究网络将 专注于土著太平洋人民（IPP）的健康差异需求，该需求定义为夏威夷本地人，其他 太平洋岛民和菲律宾人。夏威夷2个最大的卫生系统为大量提供初级保健 IPP [女王卫生系统（QHS）和夏威夷太平洋卫生（HPH）]和联邦资格 瓦胡岛的卫生中心将被邀请加入Hicrn-He。 UG3（赠款的前两年）将是 致力于开发Hicrn-He的基础设施。可分析的安全且定期更新的患者 将建立从QHS和HPH的电子健康记录得出的数据存储库以支持 健康差异问题的数据库分析。将创建临床和转化研究注册表 并维持将有趣的本地研究人员及其研究能力与寻求的人联系起来 临床研究/试验的研究人员。 Hicrn-He将开发一个框架来监视 Hicrn-He临床研究的实施阶段，以确保患者安全，遵守研究方案和 实现招聘目标的能力。 UH3阶段（赠款的3 - 5年）将致力于实施2 非酒精性脂肪肝病（NAFLD）的主题健康差异问题下的项目。项目1 将重点关注夏威夷的寿命，并评估患病率，风险，合并症和年龄 IPP中NAFLD的发作。项目2将重点关注我们性和性别少数人中NAFLD的费率和风险 患有艾滋病毒的群体以揭示可能导致风险超出这些风险的艾滋病毒特异性因素 在一般人群中。