Core B: Non-human primate core

核心B：非人类灵长类核心

基本信息

批准号：
10625274
负责人：
Michael R. Farzan
金额：
$ 55.2万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10625274
关键词：
Adverse event Animals Antibodies Biological Assay Board Certification Capsid Communication Complement DNA Dependovirus Diagnostic Disease remission Ensure Exclusion Experimental Designs Goals Healthcare Histology Human Human Resources Immunologics Immunology Individual Infection Intervention Laboratories Learning Macaca Macaca mulatta Massachusetts Measures Mediating Monitor Mus Pathologist Pathology Personal Satisfaction Pharmaceutical Preparations Primates Procedures Research Rhesus Safety Shapes Universities Validation Veterinarians Viral Viral Load result Viral load measurement Viral reservoir Wisconsin Work adeno-associated viral vector adverse event monitoring antibody-dependent cell cytotoxicity cohort histological studies improved insight neutralizing antibody nonhuman primate programs promoter seropositive simian human immunodeficiency virus success transgene expression vector virology

项目摘要

PROJECT SUMMARY (Core B – Non-human Primate Core) The overall goal of this program is to establish, optimize, and understand robust functional cures in rhesus macaques. The Non-human Primate Core (Core B) is therefore at the organizing center of this proposal, and it seeks to establish a consistent and uniform pipeline of procedures and assays for all of its non-human primate studies. An integrated pipeline is critical to the success of this Program because maximum insight from these studies will require comparisons across projects and individual animal studies. This pipeline includes efforts from the Wisconsin National Primate Research Center (WNPRC), with contributions from each of the four projects and the other cores. Core B is managed by two board-certified veterinarians. Saverio “Buddy” Capuano, DVM, at the WNPRC, and Charles Bailey, DVM, at Emmune. Dr. Capuano will directly manage all macaque studies at the WNPRC, and Dr. Bailey will coordinate the pipeline of studies outside the WNPRC and oversee virology, immunology, pathology and histology studies relevant to the Core and conducted at Emmune. Mike Farzan will oversee all of the Core’s activity and ensure its effective function, and work with Dr. Capuano to ensure regulatory compliance for all non-human primate studies.

项目摘要（核心B - 非人类灵长类动物核心）该计划的总体目标是建立，优化和理解恒河的强大功能治疗方法猕猴。因此它试图为其所有非人类灵长类动物研究。集成管道对于该计划的成功至关重要，因为最大见解从这些研究中将需要在项目和单个动物研究之间进行比较。这条管道包括威斯康星州国家灵长类动物研究中心（WNPRC）的努力，以及四个项目和其他核心中的每一个。核心B由两个经过董事会认证的兽医管理。 DVM的Saverio“ Buddy” Capuano在WNPRC和Emmune的Charles Bailey和DVM的Charles Bailey。 Capuano博士Will 直接管理WNPRC的所有猕猴研究，Bailey博士将协调研究管道在WNPRC和海外病毒学，免疫学，病理学和组织学研究之外核心并在Emmune进行。 Mike Farzan将监督所有核心的活动，并确保其有效功能，并与Capuano博士合作，以确保所有非人类灵长类动物研究的法规合规性。