Core B: Non-human primate core

核心B：非人类灵长类核心

基本信息

批准号：
10625274
负责人：
Michael R. Farzan
金额：
$ 55.2万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10625274
关键词：
Adverse event Animals Antibodies Biological Assay Board Certification Capsid Communication Complement DNA Dependovirus Diagnostic Disease remission Ensure Exclusion Experimental Designs Goals Healthcare Histology Human Human Resources Immunologics Immunology Individual Infection Intervention Laboratories Learning Macaca Macaca mulatta Massachusetts Measures Mediating Monitor Mus Pathologist Pathology Personal Satisfaction Pharmaceutical Preparations Primates Procedures Research Rhesus Safety Shapes Universities Validation Veterinarians Viral Viral Load result Viral load measurement Viral reservoir Wisconsin Work adeno-associated viral vector adverse event monitoring antibody-dependent cell cytotoxicity cohort histological studies improved insight neutralizing antibody nonhuman primate programs promoter seropositive simian human immunodeficiency virus success transgene expression vector virology

项目摘要

PROJECT SUMMARY (Core B – Non-human Primate Core) The overall goal of this program is to establish, optimize, and understand robust functional cures in rhesus macaques. The Non-human Primate Core (Core B) is therefore at the organizing center of this proposal, and it seeks to establish a consistent and uniform pipeline of procedures and assays for all of its non-human primate studies. An integrated pipeline is critical to the success of this Program because maximum insight from these studies will require comparisons across projects and individual animal studies. This pipeline includes efforts from the Wisconsin National Primate Research Center (WNPRC), with contributions from each of the four projects and the other cores. Core B is managed by two board-certified veterinarians. Saverio “Buddy” Capuano, DVM, at the WNPRC, and Charles Bailey, DVM, at Emmune. Dr. Capuano will directly manage all macaque studies at the WNPRC, and Dr. Bailey will coordinate the pipeline of studies outside the WNPRC and oversee virology, immunology, pathology and histology studies relevant to the Core and conducted at Emmune. Mike Farzan will oversee all of the Core’s activity and ensure its effective function, and work with Dr. Capuano to ensure regulatory compliance for all non-human primate studies.

项目摘要（核心 B – 非人类灵长类核心）该项目的总体目标是建立、优化和了解恒河猴的稳健功能性治疗方法因此，非人类灵长类核心（核心 B）是该提案的组织中心，它寻求为其所有非人类动物建立一致且统一的程序和检测流程灵长类动物研究的整合对于该计划的成功至关重要，因为最大程度的洞察力。这些研究需要对项目和个体动物研究进行比较。包括威斯康星州国家灵长类动物研究中心 (WNPRC) 的努力，以及来自四个项目和其他核心 B 均由两名经过董事会认证的兽医管理。 WNPRC 的 Saverio “Buddy” Capuano（兽医学博士）和 Emmune 的 Charles Bailey（兽医学博士）将担任 Capuano 博士。直接管理 WNPRC 的所有猕猴研究，贝利博士将协调研究流程在 WNPRC 之外，负责监督与该疾病相关的病毒学、免疫学、病理学和组织学研究核心并在 Emmune 进行，Mike Farzan 将监督核心的所有活动并确保其有效性。职能，并与 Capuano 博士合作，确保所有非人类灵长类动物研究的监管合规性。