Caregiver Speech and Brain-Behavior Development in Infants At-Risk for ASD

有 ASD 风险的婴儿的护理人员言语和大脑行为发育

• 批准号: 10624951
• 负责人: Meghan Rae Swanson
• 金额: $ 73.5万
• 依托单位: UNIVERSITY OF TEXAS DALLAS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-20 至 2023-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10624951
• 关键词: Address; Adult; Age; Age Months; Area; Autism Diagnosis; Axon; Biological Markers; Brain; Brain region; Caregivers; Child; Classification; Collaborations; Communication; Companions; Crying; Data; Detection; Development; Diagnosis; Diagnostic; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Distress; Early Intervention; Exposure to; Funding; Future; Goals; Growth; Hearing; Home; Human; Image; Infant; Infant Development; Intervention; Intervention Studies; Knowledge; Language; Laughter; Length; Life; Linguistics; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Monitor; National Institute on Deafness and Other Communication Disorders; Neuronal Plasticity; Outcome; Parents; Play; Predisposition; Prevention; Probability; Research; Research Personnel; Risk; Risk Marker; Sampling; Siblings; Specific qualifier value; Speech; Strategic Planning; Structure; Symptoms; Temporal Lobe; Time; Treatment Efficacy; United States National Institutes of Health; Validation; Voice; Work; autism spectrum disorder; autistic children; brain based; brain behavior; care costs; clinical practice; economic cost; evidence base; forging; high risk; high risk infant; improved; improved outcome; individuals with autism spectrum disorder; infancy; intervention effect; lexical; meetings; neurodevelopment; peer; prefrontal lobe; protective effect; public health relevance; skills; social communication; vocalization; white matter

PROJECT SUMMARY Caregiver Speech and Brain-Behavior Development in Infants At-Risk for Autism Spectrum Disorder The defining symptoms of autism spectrum disorder emerge only after an initial presymptomatic period during the first year of life. The first year of life is also a time of tremendous growth and neuroplasticity for the infant brain. The overall goal of the proposed longitudinal study is to enable and inform presymptomatic infant interventions for autism by examining the relationships between infant vocalizations, caregiver speech, and brain-behavior development in infants at high familial risk for autism. Conceptually, the project focuses on the potential protective effects of caregiver speech on infant development. The proposed study is a companion to and collaboration with the IBIS Network-Early Prediction Study, an NIH-sponsored study of 250 infants at high familial risk for autism. All infants in the study have an older sibling with autism. These high-risk infants have a 20% probability of developing autism themselves. Ecologically valid day-long home language recordings will be collected when infants are 6 and 12 months of age. A state-of-the-art automated processing pipeline will used to estimate daily counts of infant and caregiver speech quality and quantity. Micro-level targeted annotation will be applied to semi-structured, parent-infant play sessions collected in the lab. Automated processing pipelines and micro-level targeted annotation will be used to generate multivariate infant vocalizations and caregiver speech data. Infant vocalizations will be classified as speech-like or non-speech-like (delight or distress). Caregiver speech variables include lexical diversity, mean length utterance, and temporal contingency. The study will determine if infant vocalizations predict subsequent autism diagnosis and later language and social communication scores, and specify the relationship between caregiver speech and infant communication skills. Diffusion MRI will be collected when infants are 6, 12, and 24 months of age by the Early Prediction Study. The proposed study will determine if multivariate caregiver speech is related to targeted prefrontal and temporal brain regions. By determining if caregiver speech can have a protective effect on brain development, we forge a new scientific approach to studying communication development in infants at high-risk for autism. As first-year autism detection and presymptomatic intervention become increasingly feasible, an evidence base is needed to inform interventions. The proposed study will identify infant-based language and communication risk markers, caregiver-based intervention targets, and brain-based monitoring biomarkers to guide presymptomatic intervention for autism that is parent-mediated and delivered in the natural setting.

项目摘要 自闭症谱系疾病的婴儿的护理人员言语和脑行为发展 自闭症谱系障碍症状的定义症状仅在最初的预症状后才出现 生命的第一年。生命的第一年也是婴儿的巨大成长和神经可塑性的时期 脑。拟议的纵向研究的总体目标是启用和告知预症状婴儿 通过检查婴儿发声，看护人言语和 脑行为发育率是自闭症的高家族风险的婴儿。从概念上讲，该项目着重于 看护人言语对婴儿发育的潜在保护作用。拟议的研究是 以及与IBIS网络的预测研究合作，这是一项由NIH赞助的研究，对250名婴儿的研究 自闭症的家庭风险。研究中的所有婴儿都有自闭症的年龄较大的兄弟姐妹。这些高风险婴儿有 有20％的自闭症本身的可能性。 当婴儿6个月和12个月大时，将收集在生态上有效的一天的家庭语言记录。 最先进的自动加工管道将用于估计婴儿和看护人演讲的每日计数 质量和数量。微型目标注释将应用于半结构化的父母效果 在实验室收集的会议。将使用自动处理管道和微级目标注释 生成多元婴儿的发声和看护人的语音数据。婴儿发声将被归类为 语音般的或非语音的（喜悦或困扰）。看护人的语音变量包括词汇多样性，平均值 长度的话语和时间偶然性。 该研究将确定婴儿发声是否可以预测随后的自闭症诊断和以后的语言以及 社交沟通得分，并指定照顾者言语与婴儿沟通之间的关系 技能。通过早期预测研究，将在婴儿为6、12和24个月时收集扩散MRI。 拟议的研究将确定多元护理人员语音是否与靶向前额叶和时间有关 大脑区域。通过确定护理人员的言语是否可以对大脑发育产生保护作用，我们锻造 研究自闭症高危婴儿的沟通发展的新科学方法。 随着第一年的自闭症检测和预症状干预变得越来越可行，证据基础 需要告知干预措施。拟议的研究将确定基于婴儿的语言和交流 风险标记，基于护理人员的干预目标和基于大脑的监测生物标志物来指导 在自然环境中对自闭症的预症状干预。