OPAL Center Methods Core

OPAL 中心方法核心

• 批准号: 10623753
• 负责人: Melanie M Wall
• 金额: $ 47.46万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623753
• 关键词: Address; Area; Attention; Caring; Clinical; Clinical assessments; Cognitive; Cognitive deficits; Consultations; Data Science; Diagnosis; Discipline; Disparity; Educational workshop; Effectiveness; Ensure; Ethics; Evaluation; Family member; Feedback; Health; Healthcare Systems; Human Subject Research; Inequity; Infrastructure; Intervention; Investigation; Knowledge; Leadership; Learning; Longevity; Medical; Mental Health; Mental Health Services; Methods; Modeling; Outcome; Patients; Persons; Pilot Projects; Policies; Postdoctoral Fellow; Procedures; Productivity; Prognosis; Provider; Psychiatry; Qualitative Methods; Quality of life; Readiness; Recording of previous events; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Residencies; Resources; Schizophrenia; Scholars Program; Services; Source; Statistical Models; Students; Subgroup; Supervision; Technology; Training; Training and Education; Translational Research; Translations; Treatment Effectiveness; Work; career; causal model; clinical encounter; clinical training; data management; design; disparity reduction; ethnoracial; experience; health care disparity; health equity; human subject; improved; innovation; mHealth; meetings; personalized intervention; predictive modeling; programs; skills; social determinants; training opportunity; translational model; uptake

Building upon the scientific infrastructure created by the initial OPAL Center’s Methods Core, in this renewal, the Methods Core will continue to be a source of innovative research momentum focusing on improving treatment and services for people living with schizophrenia across the lifespan. Through the synergistic combination of one-on-one consultations, research methods seminars, training workshops, and cross-unit meetings, the Methods Core is designed to support OPAL’s research projects to optimize the effectiveness of treatments and services in real-world clinical settings and examine implementation issues (e.g., feasibility, acceptability) critical for enhancing readiness for broad deployment. The Methods Core will pursue the following specific aims: Aim 1. Cultivate innovative research on treatments and services for schizophrenia that optimizes their effectiveness while reducing healthcare disparities in real-world clinical settings. Cross project methods which will be developed and supported include: causal mechanistic modeling for translational research, a health equity framework, and integration of cognitive health into medical and mental health services. Aim 2. Support the work of OPAL signature and exploratory projects and pilot studies by offering perspectives and skills from multiple disciplines, and offer ideas and assistance to ensure productive use of OPAL resources. The Methods Core will include two new units – 1) cognitive health and 2) ethnoracial inequities and social determinants – and five already-established units from the ongoing OPAL methods core: 3) data science (i.e. research design, causal and predictive modeling, data management); 4) qualitative methods; 5) clinical assessment and training; 6) technology/mHealth; and 7) ethics and human subjects. The Methods Core will respond to requests from the Administrative Core, especially with regard to evaluation of Center activities, or when the Administrative Core needs direction in solicitation or review of pilot study proposals. Aim 3. Challenge students and early stage investigators to build skills and experience in critically needed transdisciplinary areas of study, and provide on-going feedback on their work and career trajectories.

基于最初蛋白石中心的方法核心创建的科学基础设施，在此续签中 方法核心将继续成为创新研究势头的来源，致力于改善 在整个生命周期中为精神分裂症患者提供治疗和服务。通过协同作用 一对一咨询，研究方法，培训研讨会和跨单元的结合 会议，方法核心旨在支持Opal的研究项目，以优化 现实世界中的临床环境和检查实施问题中的治疗和服务（例如，可行性， 可接受性）至关重要的是增强对广泛部署的准备。方法核心将追求 遵循特定目的： 目标1。培养有关精神分裂症治疗和服务的创新研究，以优化其 在减少现实世界临床环境中的医疗保健分布的同时，有效性。跨项目方法 将开发和支持包括：转化研究的因果机械建模，健康 公平框架，以及将认知健康融入医学和心理健康服务。 目标2。通过提供观点来支持蛋白石签名和探索性项目和试点研究的工作 以及来自多个学科的技能，并提供想法和帮助以确保有效地使用蛋白石 资源。方法核心将包括两个新单元 - 1）认知健康和2）民族不平等现象和 社会决定者 - 以及正在进行的蛋白石方法核心的五个已经建立的单元：3）数据科学 （即研究设计，因果和预测建模，数据管理）； 4）定性方法； 5）临床 评估和培训； 6）技术/MHealth； 7）伦理和人类主体。方法核心将 回应行政核心的请求，尤其是在评估中心活动或 当行政核心需要指示试点研究建议的征求或审查时。 目标3。挑战学生和早期调查人员，以建立技能和经验 跨学科研究领域，并提供有关其工作和职业轨迹的持续反馈。