NRSA in Genetics

NRSA 遗传学

• 批准号: 10623341
• 负责人: JEFF J. SEKELSKY
• 金额: $ 74.27万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623341
• 关键词: Genetic; National Research Service Awards

The Curriculum in Genetics and Molecular Biology (GMB) is a well-established and highly-ranked interdepartmental PhD program at the University of North Carolina at Chapel Hill (UNC-CH). For more than 50 years this program has provided cutting-edge research opportunities to trainees. In addition to our ongoing expertise in key areas in genetics (e.g., genetics of model microbes, plants, and animals) and molecular biology (e.g., signal transduction, gene expression, and virology), we have added strengths in epigenetics, clinical and translational genetics, systems genetics, quantitative genetics, computational genetics, and genomics. Extensive interaction between researchers in diverse areas is promoted by the interdepartmental and inter-school nature of the program, as well as many faculty centers, and is facilitated by the physical proximity of the different units on a single campus. Our mission is to train students from diverse backgrounds to conduct responsible research leading to a PhD, while also providing training and acquisition of skills for them to enter a variety of careers in research and research-related fields. We continuously update our program, based on our own studies and best practices throughout the field to ensure that it is modern and innovative. Several years ago we added “modular” 5-week courses that allow students to tailor their coursework more closely to their needs. We offer numerous career information and training events, as well as internships in industry, academia, and non-profit sectors. We compete nationally for the top students and have successfully recruit students from a variety of backgrounds, with about 20% belonging to one of the NIH-defined diversity groups. Our students are successful in obtaining competitive external funding, and every student publishes at least one first-authored research paper in a peer-reviewed journal. The vast majority of our students remain in scientific careers after they graduate. Most initially do postdoctoral research in academia, government labs, or private research foundations. Some remain in academic/government research, but others go into industry, science teaching, or science policy.

遗传学和分子生物学（GMB）的课程是一个良好且高度的 北卡罗来纳大学教堂山（UNC-CH）的跨部门博士学位课程。超过50 多年来，该计划为受训者提供了尖端的研究机会。除了我们正在进行的 遗传学关键领域的专业知识（例如模型微生物，植物和动物的遗传学）和分子 生物学（例如，信号转导，基因表达和病毒学），我们在表观遗传学中增加了优势， 临床和翻译的遗传学，系统遗传学，定量遗传学，计算遗传学和 基因组学。跨部门促进了潜水区研究人员之间的广泛互动 该计划以及许多教师中心的学业性质，并由身体准备 单个校园中不同单位的距离。 我们的使命是培训来自潜水员背景的学生，以进行负责任的研究，以实现 博士学位，同时还为他们提供培训和获取技能，以使他们进入研究和 与研究相关的领域。我们继续根据自己的研究和最佳实践来更新我们的计划 通过该领域，以确保它具有现代性和创新性。几年前，我们添加了“模块化” 5周 允许学生更紧密地量身定制课程的课程。我们提供许多职业 信息和培训活动，以及行业，学术界和非营利性部门的企业。 我们在全国范围内竞争顶级学生，并成功地招募了来自各种各样的学生 背景，约有20％属于NIH定义的多样性群体之一。我们的学生是 成功地获得了竞争性的外部资金，每个学生至少出版了一本最初的作品 研究论文在同行评审期刊上。我们绝大多数学生在科学职业之后继续 他们毕业。最初，最初在学术界，政府实验室或私人研究中进行博士后研究 基础。有些人仍在学术/政府研究中，但有些人从事行业，科学教学或 科学政策。

项目成果

The Embryonic Origin of Primordial Germ Cells in the Tardigrade Hypsibius exemplaris.

缓步动物 Hypsibius exemplaris 原始生殖细胞的胚胎起源。

• DOI: 10.1101/2023.01.02.522500
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Heikes,KiraL;Game,Mandy;Smith,FrankW;Goldstein,Bob
• 通讯作者: Goldstein,Bob

Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems.

• DOI: 10.1186/s12974-022-02459-1
• 发表时间: 2022-04-23
• 期刊: Journal of neuroinflammation
• 影响因子: 9.3

Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4.

• DOI: 10.1021/acs.jmedchem.2c00185
• 发表时间: 2022-05-26
• 期刊: Journal of medicinal chemistry
• 影响因子: 7.3
• 作者: Fleming MC;Chiou LF;Tumbale PP;Droby GN;Lim J;Norris-Drouin JL;Williams JG;Pearce KH;Williams RS;Vaziri C;Bowers AA
• 通讯作者: Bowers AA

Centromere-Proximal Suppression of Meiotic Crossovers in Drosophila is Robust to Changes in Centromere Number and Repetitive DNA Content.

果蝇减数分裂交叉的着丝粒近端抑制对于着丝粒数量和重复 DNA 含量的变化具有鲁棒性。

• DOI: 10.1101/2023.10.17.562696
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Pazhayam,NilaM;Frazier,LeahK;Sekelsky,Jeff
• 通讯作者: Sekelsky,Jeff

Reduced histone gene copy number disrupts Drosophila Polycomb function.

组蛋白基因拷贝数减少会破坏果蝇多梳功能。

• DOI: 10.1093/genetics/iyad106
• 发表时间: 2023
• 期刊: Genetics
• 影响因子: 3.3
• 作者: McPherson,Jeanne-MarieE;Grossmann,LucyC;Salzler,HarmonyR;Armstrong,RobinL;Kwon,Esther;Matera,AGregory;McKay,DanielJ;Duronio,RobertJ
• 通讯作者: Duronio,RobertJ