Illuminating the Developmental Etiology of Youth Resilience

阐明青少年复原力的发展病因学

• 批准号: 10597361
• 负责人: Alexandra Yvette Vazquez
• 金额: $ 3.97万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-02 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10597361
• 关键词: Academic achievement; Adolescence; Area; Attention; Base Sequence; Bioinformatics; Biological; Biological Markers; Biological Process; Child; Child Development; Childhood; Chronic; Competence; Confounding Factors (Epidemiology); Consensus; Cross-Sectional Studies; DNA; DNA Methylation; Data; Data Analyses; Data Set; Databases; Development; Developmental Course; Dimensions; Disparate; Early identification; Environment; Epigenetic Process; Ethics; Etiology; Exposure to; Failure; Fellowship; Fostering; Genes; Genetic; Goals; Grant; Growth; Heritability; Human; Individual; Intervention; Knowledge; Literature; Manuscripts; Methylation; Michigan; Modeling; Monozygotic twins; National Research Service Awards; Neighborhoods; Organism; Outcome; Pathway interactions; Pattern; Phenotype; Policies; Poverty; Preparation; Process; Psychopathology; Research; Research Personnel; Role; Sampling; Statistical Methods; Stress; Time; Training; Twin Multiple Birth; Twin Studies; Work; Youth; cell type; community violence; early adolescence; epigenetic marker; experience; informant; longitudinal dataset; methylome; methylomics; middle childhood; neighborhood disadvantage; neurogenetics; predictive marker; programs; promote resilience; resilience; sex; skills; social; social skills; stressor; theories

Project Summary/Abstract Youth resilience is best conceptualized as multidimensional1–3 and dynamic,4–6 such that individuals may demonstrate changes in academic, social, or psychiatric resilience over time. Despite this broad consensus, the majority of empirical work on resilience has been cross-sectional and tends to focus on a single domain of resilience (e.g., psychiatric resilience). This has notably limited the field’s understanding of the development of resilience over time, including the trajectories that best characterize resilience, the specific biological mechanisms underlying those trajectories, and whether domains of resilience follow similar or disparate developmental courses. The current F31 proposal will address these gaps in the literature by examining the developmental etiology of youth resilience to neighborhood adversity by using a large multi-informant and multi-wave dataset of twins exposed to substantial levels of neighborhood disadvantage (e.g., poverty, community violence). Specific Aim 1 will employ growth mixture models to group individuals based on their domain-specific patterns of resilience (i.e., academic, social, psychiatric) across three time points: middle childhood, early adolescence, and late adolescence; the first study of its kind. Specific Aim 2 will identify longitudinally-predictive biomarkers of resilience trajectories through the first methylome wide association study (MWAS) of resilience development. To eliminate genetic confounds prominent in human epigenetic studies, I will also include discordant monozygotic twin difference analyses. By illuminating the developmental etiology of resilience, these findings should inform policy and intervention efforts for youth in disadvantaged neighborhood contexts. To facilitate the completion of these aims, the proposed NRSA fellowship will provide training in 1) longitudinal statistical methods, 2) advanced epigenetic analytics, 3) the development of an integrated, conceptual theory of the development of resilience (essential for understanding the results for scientific aims 1 and 2 given the dearth of relevant literature), 4) the preparation of grants and manuscripts, and 5) the ethical conduct of research. These five areas of training will significantly further my development as an independent interdisciplinary researcher and ultimately facilitate my goal of creating a program of research focused on the study of youth resilience within a developmentally, genetically, and environmentally informed context.

项目摘要/摘要 青年的弹性最好被概念化为多维1-3和动态，4-6，以使个人可以 随着时间的流逝，表明学术，社会或精神病弹性的变化。尽管达成了广泛的共识，但 关于弹性的大多数经验工作都是横断面的，倾向于集中于 弹性（例如，精神病弹性）。这显着限制了该领域对发展的理解 随着时间的推移的弹性，包括最能表征弹性的轨迹，特定的生物学 这些轨迹背后的机制，以及弹性域是否遵循相似还是不同 发展课程。当前的F31提案将通过检查文献中的这些差距 通过使用大型多信息和 双胞胎的多波数据集暴露于大量邻里灾难（例如，贫困， 社区暴力）。特定的目标1将根据他们 特定领域的弹性模式（即学术，社会，精神病学）跨三个时间点：中间 童年，青少年早期和晚期青少年；同类的第一个研究。具体目标2将确定 通过第一个甲基团宽的关联研究，纵向预测的弹性轨迹的生物标志物 （MWA）的弹性发展。为了消除人类表观遗传研究中突出的遗传混杂，I 还将包括不一致的单卵双胞胎差异分析。通过阐明 韧性，这些发现应为处境不利的社区青年的政策和干预工作提供依据 上下文。 为了促进这些目标的完成，拟议的NRSA奖学金将在1）纵向中提供培训 统计方法，2）高级表观遗传分析，3）综合概念理论的发展 弹性的发展（对于理解科学目的1和2的结果至关重要 相关文献的死亡），4）赠款和手稿的准备，5） 研究。这五个培训领域将大大进一步发展我作为独立的发展 跨学科研究人员，最终支持我创建一个研究计划的目标 在发达，一般和环境知情的环境中研究青年的弹性。