Research Training in Chemistry and Chemical Biology

化学和化学生物学研究培训

• 批准号: 10624303
• 负责人: Jason E Gestwicki
• 金额: $ 63.66万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10624303
• 关键词: Biology; Chemicals; Chemistry; Research Training

Project Summary The goal of the UCSF Chemistry and Chemical Biology (CCB) predoctoral training program is to foster research in the use of chemical strategies to probe fundamental biological questions. The overall program curriculum focuses on: 1) rigorous didactic and hands-on training courses at the chemistry-biology interface in the first year; 2) research rotations in three different labs during that same year; 3) selection of a thesis advisor and development of an independent research proposal at the end of the first year; 4) an intensive oral qualifying exam in the second year; 5) individual thesis research with a focus on impact, collaboration and publication and finally; 6) a dissertation seminar. Integrated throughout this training program, from the first day to the last, are activities that train and encourage trainees to: i) develop skills in responsible conduct of research (RCR), rigor & reproducibility and chemical and biological safety; ii) openly receive and give feedback through evaluation and assessment tools; iii) foster career interests, including use of Individual Development Plans (IDPs); iv) enhance written and oral communication skills; (v) celebrate diversity and a sense of community and vi) gain training in critical analysis via journal clubs, seminars and minicourses. The research in the CCB program is highly inter- disciplinary and broadly categorized as: biological chemistry and synthetic biology, computational chemistry and biology, chemical synthesis and natural products, drug discovery and design, macromolecular structure and function and protein and cellular engineering. To enact this training program, the CCB program is not associated with a specific department; rather, we bring together 48 faculty from nine different academic departments and two research institutes across UCSF’s world-class research enterprise. These faculty are rigorously and holistically evaluated by the CCB Executive Committee, for excellence in research, mentoring and commitment to diversity, and these faculty are required to complete annual mentor training. They are among the best scientists in the world (3 HHMI Investigators, 10 NAS members; Lasker, Kavli Prize winners; avg $808,000/yr in funding). Oversight of the CCB program is maintained by the Executive Committee, along with an engaged Dean of the UCSF Graduate School and an expert External Advisory Committee. This CBI proposal builds on 20+ years of educational excellence at the chemistry-biology interface and it has no equivalent elsewhere on the UCSF campus. Approximately 12 students are enrolled annually from a pool of ~220 applicants after a rigorous application process that culminates in personal interviews. Enrolled students from under-represented minority (URM) groups now represent ~16% of the total, with an overall M/F ratio of ~50%. The URM candidates, those from disadvantaged backgrounds and students with disabilities are actively sought in an extensive series of outreach programs, including Science Education Partnership (SEP), an undergraduate Summer Research Training Program (SRTP) and the PROPEL post-bac program. Our graduates are highly sought-after in academia, industry and beyond, because of their training, creativity and passion for inter-disciplinary science.

项目概要 加州大学旧金山分校化学与化学生物学 (CCB) 博士前培训计划的目标是促进研究 使用化学策略来探索基本的生物学问题。 重点关注：1）第一年化学-生物界面严格的教学和实践培训课程； 2) 同年在三个不同的实验室进行研究轮转 3) 选择论文导师； 第一年结束时制定独立的研究计划； 4) 强化口头资格赛； 第二年考试；5）个人论文研究，重点是影响、合作和出版； 最后； 6) 论文研讨会贯穿整个培训计划，从第一天到最后一天。 培训和鼓励受训者的活动： i) 培养负责任的研究行为 (RCR)、严谨性和 再现性以及化学和生物安全性； ii) 通过评估公开接受并提供反馈； 评估工具； iii) 培养职业兴趣，包括使用个人发展计划 (IDP)； iv) 增强 书面和口头沟通技巧；(v) 弘扬多样性和社区意识；以及 vi) 获得以下方面的培训： 通过期刊俱乐部、研讨会和迷你课程进行批判性分析 CCB 项目的研究具有高度的互动性。 学科，大致分为：生物化学和合成生物学、计算化学和 生物学、化学合成与天然产物、药物发现与设计、大分子结构与 功能与蛋白质和细胞工程的制定与 CCB 计划无关。 相反，我们汇集了来自 9 个不同学术部门的 48 名教师， 加州大学旧金山分校世界级研究企业的两个研究机构这些教师都非常严谨。 由 CCB 执行委员会对研究、指导和承诺方面的卓越表现进行全面评估 多元化，这些教师必须完成年度导师培训。 世界各地的科学家（3 名 HHMI 调查员、10 名 NAS 成员；拉斯克奖、卡维理奖获得者；平均每年 808,000 美元 CCB 项目的监督由执行委员会和一名参与的院长负责。 该 CBI 提案建立在 20+ 的基础上。 多年来在化学-生物交叉领域的卓越教育，在其他领域是无与伦比的 加州大学旧金山分校校园每年约 12 名学生经过严格的筛选后从约 220 名申请者中被录取。 申请过程最终以个人面试结束。 (URM) 群体目前约占总数的 16%，总体 M/F 比例约为 50%。 通过一系列广泛的活动，积极寻找来自弱势背景和残疾的学生 外展计划，包括科学教育合作伙伴关系（SEP）、本科生暑期研究 培训计划 (SRTP) 和 PROPEL 学士后计划我们的毕业生在以下领域广受欢迎。 学术界、工业界及其他领域，因为他们的训练、创造力和对跨学科科学的热情。

项目成果

A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers.

• DOI: 10.1021/acscentsci.2c01449
• 发表时间: 2023-05-24
• 期刊: ACS CENTRAL SCIENCE
• 影响因子: 18.2
• 作者: Kenanova, Dyana N.;Visser, Emira J.;Virta, Johanna M.;Sijbesma, Eline;Centorrino, Federica;Vickery, Holly R.;Zhong, Mengqi;Neitz, R. Jeffrey;Brunsveld, Luc;Ottmann, Christian;Arkin, Michelle R.
• 通讯作者: Arkin, Michelle R.

The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT).

• DOI: 10.1016/j.jmb.2023.168026
• 发表时间: 2023-06-01
• 期刊: JOURNAL OF MOLECULAR BIOLOGY
• 影响因子: 5.6
• 作者: Nadel, Cory M.;Thwin, Aye C.;Callahan, Matthew;Lee, Kanghyun;Connelly, Emily;Craik, Charles S.;Southworth, Daniel R.;Gestwicki, Jason E.
• 通讯作者: Gestwicki, Jason E.

Proteomic characterization of phagocytic primary human monocyte-derived macrophages.

• DOI: 10.1039/d2cb00076h
• 发表时间: 2022-06-08
• 期刊: RSC CHEMICAL BIOLOGY
• 影响因子: 4.1
• 作者: Volk, Regan F.;Montano, Jose L.;Warrington, Sara E.;Hofmann, Katherine L.;Zaro, Balyn W.
• 通讯作者: Zaro, Balyn W.

Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020.

• DOI: 10.1128/aac.00054-22
• 发表时间: 2022-05-17
• 期刊: Antimicrobial agents and chemotherapy
• 影响因子: 4.9

Covalent Proteins as Targeted Radionuclide Therapies Enhance Antitumor Effects.

• DOI: 10.1021/acscentsci.3c00288
• 发表时间: 2023-06-28
• 期刊: ACS CENTRAL SCIENCE
• 影响因子: 18.2
• 作者: Klauser, Paul C.;Chopra, Shalini;Cao, Li;Bobba, Kondapa Naidu;Yu, Bingchen;Seo, Youngho;Chan, Emily;Flavell, Robert R.;Evans, Michael J.;Wang, Lei
• 通讯作者: Wang, Lei