Research Training in Chemistry and Chemical Biology

化学和化学生物学研究培训

• 批准号: 10624303
• 负责人: Jason E Gestwicki
• 金额: $ 63.66万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10624303
• 关键词: Biology; Chemicals; Chemistry; Research Training

Project Summary The goal of the UCSF Chemistry and Chemical Biology (CCB) predoctoral training program is to foster research in the use of chemical strategies to probe fundamental biological questions. The overall program curriculum focuses on: 1) rigorous didactic and hands-on training courses at the chemistry-biology interface in the first year; 2) research rotations in three different labs during that same year; 3) selection of a thesis advisor and development of an independent research proposal at the end of the first year; 4) an intensive oral qualifying exam in the second year; 5) individual thesis research with a focus on impact, collaboration and publication and finally; 6) a dissertation seminar. Integrated throughout this training program, from the first day to the last, are activities that train and encourage trainees to: i) develop skills in responsible conduct of research (RCR), rigor & reproducibility and chemical and biological safety; ii) openly receive and give feedback through evaluation and assessment tools; iii) foster career interests, including use of Individual Development Plans (IDPs); iv) enhance written and oral communication skills; (v) celebrate diversity and a sense of community and vi) gain training in critical analysis via journal clubs, seminars and minicourses. The research in the CCB program is highly inter- disciplinary and broadly categorized as: biological chemistry and synthetic biology, computational chemistry and biology, chemical synthesis and natural products, drug discovery and design, macromolecular structure and function and protein and cellular engineering. To enact this training program, the CCB program is not associated with a specific department; rather, we bring together 48 faculty from nine different academic departments and two research institutes across UCSF’s world-class research enterprise. These faculty are rigorously and holistically evaluated by the CCB Executive Committee, for excellence in research, mentoring and commitment to diversity, and these faculty are required to complete annual mentor training. They are among the best scientists in the world (3 HHMI Investigators, 10 NAS members; Lasker, Kavli Prize winners; avg $808,000/yr in funding). Oversight of the CCB program is maintained by the Executive Committee, along with an engaged Dean of the UCSF Graduate School and an expert External Advisory Committee. This CBI proposal builds on 20+ years of educational excellence at the chemistry-biology interface and it has no equivalent elsewhere on the UCSF campus. Approximately 12 students are enrolled annually from a pool of ~220 applicants after a rigorous application process that culminates in personal interviews. Enrolled students from under-represented minority (URM) groups now represent ~16% of the total, with an overall M/F ratio of ~50%. The URM candidates, those from disadvantaged backgrounds and students with disabilities are actively sought in an extensive series of outreach programs, including Science Education Partnership (SEP), an undergraduate Summer Research Training Program (SRTP) and the PROPEL post-bac program. Our graduates are highly sought-after in academia, industry and beyond, because of their training, creativity and passion for inter-disciplinary science.

项目摘要 UCSF化学和化学生物学（CCB）的目标是培养研究 在使用化学策略来探讨基本生物学问题。整体课程课程 重点关注：1）第一年的化学生物学界面上严格的教学和动手培训课程； 2）同年在三个不同实验室的研究旋转； 3）选择论文顾问和 在第一年底制定独立的研究建议； 4）高度口头资格 第二年考试； 5）个人论文研究的重点是影响，协作和出版和 最后; 6）论文精液。从第一天到最后的整个培训计划整合了整个培训计划 培训和鼓励学员的活动：i）发展负责任的研究技能（RCR），严格＆ 可重复性以及化学和生物学安全； ii）通过评估公开接收并提供反馈 评估工具； iii）促进职业兴趣，包括使用个人发展计划（IDP）； iv）增强 书面和口头沟通技巧； （v）庆祝多样性和一种社区感和vi）获得培训 通过期刊俱乐部，半小伙子和微型赛的批判性分析。 CCB计划中的研究高度相互 纪律，广泛分类为：生物化学和合成生物学，计算化学和 生物学，化学合成和天然产物，药物发现与设计，大分子结构和 功能，蛋白质和细胞工程。为了制定此培训计划，CCB计划与 与特定部门；相反，我们汇集了来自九个不同学术部门的48位教职员工， UCSF世界一流的研究企业中的两家研究机构。这些教师严格 由CCB执行委员会整体评估，以卓越的研究，心理和承诺 多样性，这些教师必须完成年度心理培训。他们是最好的 世界上的科学家（3名HHMI调查人员，10名NAS成员； Lasker，Kavli奖得主； AVG $ 808,000/年 资金）。执行委员会对CCB计划的监督以及订婚的院长 UCSF研究生院和专家外部咨询委员会的成员。该CBI提案建立在20多个 在化学生物学界面上的教育卓越多年，它在其他地方没有等效 UCSF校园。严格之后，每年约有12名学生每年从一个约220名申请人中注册 申请流程最终在个人面试中。来自代表不足的少数民族的学生 （URM）组现在占总数的约16％，总体M/F比约为50％。 URM候选人，那些 在不利的背景和残疾学生中，积极寻求一系列广泛的领域 外展计划，包括科学教育合作伙伴关系（SEP），这是一项本科夏季研究 培训计划（SRTP）和PREPEL BAC计划。我们的毕业生在 由于他们对跨学科科学的培训，创造力和热情，学术界，工业及其他地区。

项目成果

A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers.

• DOI: 10.1021/acscentsci.2c01449
• 发表时间: 2023-05-24
• 期刊: ACS CENTRAL SCIENCE
• 影响因子: 18.2
• 作者: Kenanova, Dyana N.;Visser, Emira J.;Virta, Johanna M.;Sijbesma, Eline;Centorrino, Federica;Vickery, Holly R.;Zhong, Mengqi;Neitz, R. Jeffrey;Brunsveld, Luc;Ottmann, Christian;Arkin, Michelle R.
• 通讯作者: Arkin, Michelle R.

The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT).

• DOI: 10.1016/j.jmb.2023.168026
• 发表时间: 2023-06-01
• 期刊: JOURNAL OF MOLECULAR BIOLOGY
• 影响因子: 5.6
• 作者: Nadel, Cory M.;Thwin, Aye C.;Callahan, Matthew;Lee, Kanghyun;Connelly, Emily;Craik, Charles S.;Southworth, Daniel R.;Gestwicki, Jason E.
• 通讯作者: Gestwicki, Jason E.

Proteomic characterization of phagocytic primary human monocyte-derived macrophages.

• DOI: 10.1039/d2cb00076h
• 发表时间: 2022-06-08
• 期刊: RSC CHEMICAL BIOLOGY
• 影响因子: 4.1
• 作者: Volk, Regan F.;Montano, Jose L.;Warrington, Sara E.;Hofmann, Katherine L.;Zaro, Balyn W.
• 通讯作者: Zaro, Balyn W.

Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission.

• DOI: 10.7554/elife.86636
• 发表时间: 2023-07-14
• 期刊: eLife
• 影响因子: 7.7
• 作者: Sapiro AL;Hayes BM;Volk RF;Zhang JY;Brooks DM;Martyn C;Radkov A;Zhao Z;Kinnersley M;Secor PR;Zaro BW;Chou S
• 通讯作者: Chou S

Covalent Proteins as Targeted Radionuclide Therapies Enhance Antitumor Effects.

• DOI: 10.1021/acscentsci.3c00288
• 发表时间: 2023-06-28
• 期刊: ACS CENTRAL SCIENCE
• 影响因子: 18.2
• 作者: Klauser, Paul C.;Chopra, Shalini;Cao, Li;Bobba, Kondapa Naidu;Yu, Bingchen;Seo, Youngho;Chan, Emily;Flavell, Robert R.;Evans, Michael J.;Wang, Lei
• 通讯作者: Wang, Lei