Neurobiology of CNS Injury and Repair

中枢神经系统损伤与修复的神经生物学

• 批准号: 10620787
• 负责人: Warren Joseph Alilain
• 金额: $ 21.27万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620787
• 关键词: Neurobiology; central nervous system injury; injury and repair

Project Summary This is a renewal application requesting continued funding for a Neurobiology of CNS Injury and Repair T32 Training Program to support 4 predoctoral fellows per year for a 2-year training period, working toward their PhD degrees in the fields of traumatic brain injury (TBI), spinal cord injury (SCI), or stroke. The overall goal continues to be to prepare highly motivated graduate students for careers in neurotrauma research-related fields by providing broad-based training in the pathophysiology of TBI, SCI, and stroke and the identification of potential disease-modifying molecular targets that can drive the discovery of pharmacological or gene-based therapeutic strategies. An Executive Committee will select trainees from a pool of qualified applicants, generally in their third year of PhD training. Trainees will receive intensive hands-on research mentoring, with an emphasis on understanding and applying quantitative assessment tools in laboratories of Training Faculty appointed in the Depts. of Neuroscience, Physiology, Molecular and Cellular Biochemistry, and Pharmaceutical Sciences who regularly interact and collaborate through their affiliation with the University of Kentucky's (UK) Spinal Cord & Brain Injury Research Center and Center for Advanced Translational Stroke Science (CATSS). In addition to coursework, trainees will engage in journal clubs, responsible conduct of research training, Center and Departmental seminar series, and a customized set of program-wide meetings in Professional Skills, and Quantitative Literacy-Experimental Design and Statistics (PSQL-EDS). The monthly PSQL-EDS will facilitate active learning of concepts such as quantitative literacy, statistical analysis, and scientific rigor, as well as scientific writing and professional development. Of the students appointed to the T32 Program in the previous 9 years, 13 have completed their PhDs, 2 will complete their PhDs in year 10, and 6 will continue their PhD training. All those that completed their PhDs continued into science-related positions. Several are continuing their education (3 postdocs, 1 resident), one is an AAAS science policy fellow at the NIH, and the majority are pursuing careers in academia (3 Assistant Professors, 1 instructor, 1 researcher) and biomedical industry (2). The PhD completion and career placement success of the T32 Program is further highlighted by an outstanding record of recruiting and retaining diverse trainees: a large proportion of appointees are of underrepresented race or ethnicity, have a disability, or come from disadvantaged backgrounds. The program's success and continued evolution will be guided by two groups: an Executive Committee comprised of the Program Directors, Training Faculty, and senior UK faculty who bring expertise in administration, mentoring, and inclusion research initiatives, and an External Advisory Board of national leaders in TBI, SCI, and stroke research. Through the pairing of comprehensive, research-intensive training with didactic and interactive educational/career development activities delivered from diverse perspectives, this T32 Program is uniquely positioned to fill a growing need for rigorously trained scientists who desire careers in neurotrauma.

项目概要 这是一份续签申请，要求继续资助中枢神经系统损伤和修复的神经生物学 T32 培训计划每年支持 4 名博士前研究员进行为期 2 年的培训，努力实现他们的目标 创伤性脑损伤 (TBI)、脊髓损伤 (SCI) 或中风领域的博士学位。总体目标 继续为积极主动的研究生做好神经创伤研究相关职业的准备 通过提供 TBI、SCI 和中风病理生理学方面的广泛培训以及识别 潜在的疾病缓解分子靶点，可以推动药理学或基于基因的药物的发现 治疗策略。执行委员会将从合格的申请者中挑选受训者， 通常是在博士培训的第三年。学员将接受密集的实践研究指导， 强调理解和应用培训学院实验室的定量评估工具 任命于各部门。神经科学、生理学、分子和细胞生物化学以及制药学系 通过与肯塔基大学（英国）的联系​​定期互动和合作的科学界人士 脊髓和脑损伤研究中心和高级转化中风科学中心 (CATSS)。 除了课程作业外，学员还将参加期刊俱乐部、负责任地进行研究培训、 中心和部门研讨会系列，以及一套定制的专业课程范围内的会议 技能和定量素养 - 实验设计和统计 (PSQL-EDS)。每月的 PSQL-EDS 将 促进主动学习定量素养、统计分析和科学严谨性等概念， 以及科学写作和专业发展。被指定参加 T32 项目的学生中 过去 9 年中，13 人已完成博士学位，2 人将在第 10 年完成博士学位，6 人将继续攻读博士学位 博士培养。所有完成博士学位的人都继续担任与科学相关的职位。有几个是 继续教育（3 名博士后，1 名住院医师），其中一名是 NIH 的 AAAS 科学政策研究员，另一名是 大多数人在学术界（3 名助理教授、1 名讲师、1 名研究员）和生物医学领域从事职业生涯 工业（2）。 T32 项目的博士学位完成和职业安置的成功进一步凸显 在招募和留住多元化学员方面拥有出色的记录：大部分被任命的学员都是来自 代表性不足的种族或族裔、有残疾或来自弱势背景。这 该计划的成功和持续发展将由两个小组指导： 执行委员会 项目总监、培训教师和英国高级教师带来了管理方面的专业知识， 指导和包容性研究计划，以及由 TBI、SCI、 和中风研究。通过将全面的、研究密集型的培训与教学和培训相结合 T32 项目从不同角度提供互动式教育/职业发展活动 其独特的定位可以满足对神经创伤领域经过严格训练的科学家日益增长的需求。