Neurobiology of CNS Injury and Repair

中枢神经系统损伤与修复的神经生物学

• 批准号: 10200898
• 负责人: KATHRYN E SAATMAN
• 金额: $ 4.62万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200898
• 关键词: Neurobiology; central nervous system injury; injury and repair

PROJECT SUMMARY/ABSTRACT This is a renewal application requesting continued funding for a Neurobiology of CNS Injury and Repair T32 Training Program to support 4 predoctoral fellows working toward their Ph.D. degrees. During the first 4 years of the original funding period, 11 trainees have been appointed to the 2 year program, of which 5 have completed training and their Ph.D.s (3 in Physiology and 2 in Anatomy & Neurobiology). Of those 5, 2 are currently postdoctoral fellows, 2 have been hired into university faculty positions and 1 has moved on to medical school. Of the other 6 trainees, 2 are expected to finish their Ph.D.s during year 5 of the initial funding period. The remaining 4 are anticipated to complete their doctorates within the next two to three years. The training of the predoctoral fellows will be mainly carried out by training faculty whose primary appointments are either within the University of Kentucky (UK) Spinal Cord & Brain Injury Research Center (SCoBIRC) or are the affiliated with it as SCoBIRC Faculty Associates. Three of the SCoBIRC faculty associates have their primary appointments within the UK Sanders-Brown Center on Aging (SBCoA). In addition to their primary appointments, the SCoBIRC and/or SBCoA training faculty have their academic appointments in one of three UK College of Medicine basic science departments: Anatomy & Neurobiology, Physiology, or Molecular & Cellular Biochemistry. One additional training faculty is from the UK College of Pharmacy Department of Pharmaceutical Sciences. The overall goal of the proposed program will continue to be providing broad-based training in modern research concepts regarding the acute, subacute and chronic pathophysiology of SCI, TBI and stroke, and the identification of potential disease-modifying molecular targets that can drive the discovery of pharmacological or gene therapeutic strategies by which the devastating effects of these injuries can be ameliorated. These strategies will include both “neuroprotective” and “neurorestorative” approaches. Although it is anticipated that most of the trainees will pursue careers in laboratory-based therapeutic discovery research, they will also receive training in clinical aspects of the targeted neurological disorders and the practical issues involved in the design and conduct of neurological clinical trials. To accomplish this, the predoctoral fellows will spend one day/week for a semester shadowing one of 6 Clinical Tutors from the Departments Neurosurgery and Physical Medicine & Rehabilitation, and will attend weekly grand rounds to gain an understanding of the clinical nature of TBI and SCI upon which their research is focused. This will enhance their ability as independent investigators to not only make therapeutic discoveries in experimental neurotrauma and stroke injury models, but also provide them with knowledge concerning how to design their basic research in a manner that will more readily enable the translation of promising therapeutic approaches into clinical studies and therapeutic trials.

项目摘要/摘要 这是一项续签申请，要求继续为中枢神经系统受伤的神经生物学提供资金 维修T32培训计划，以支持4名攻读博士学位的前者。学位。 在原始资金期的头四年中，已任命11名学员到2年 计划，其中5个已经完成培训及其博士学位（生理学3和2个解剖学和2个 神经生物学）。在这5个，当前有2个是博士后研究员中，有2名被聘为大学教师 职位和1已进入医学院。在其他6名学员中，有2名将完成他们的 初始资金期限第五年的博士学位。预计其余4将完成他们的 未来两到三年的博士学位。培训餐饮前研究员将主要进行 通过培训教师的主要任命在肯塔基大学（英国） 脊髓和脑损伤研究中心（SCOBIRC），或者是SCOBIRC教师的关联 同事。 SCOBIRC教师中有三个在英国在英国的主要任命 桑德斯棕色老化中心（SBCOA）。除了主要任命外，Scobirc 和/或SBCOA培训学院在英国三所医学院之一中任命 基础科学部门：解剖学和神经生物学，生理学或分子和细胞生物化学。 另一项培训教师来自英国药学系 科学。拟议计划的总体目标将继续提供基于广泛的培训 有关SCI，TBI和 中风，以及可以驱动发现的潜在疾病改良的分子靶标的鉴定 这些伤害的毁灭性作用的药物或基因治疗策略可以 改善。这些策略将包括“神经保护性”和“神经抑制”方法。 尽管预计大多数培训将追随基于实验室的治疗 发现研究，他们还将接受针对性神经系统的临床方面的培训 神经系统临床试验的设计和行为涉及的疾病和实际问题。到 做到这一点，前专家们将花一天/周的时间花一个学期，以遮蔽6个 部门神经外科和物理医学与康复的临床导师，将 参加每周的大巡回赛，以了解TBI和SCI的临床性质 他们的研究是集中的。这将增强他们作为独立调查员的能力，不仅使 实验性神经瘤和中风损伤模型中的治疗性发现，但也提供 借助如何以更容易启用的方式设计基础研究的知识 有希望的治疗方法转化为临床研究和治疗试验。