Image-Guided Focused Ultrasound Treatment of Abscesses

图像引导聚焦超声治疗脓肿

基本信息

批准号：
10620783
负责人：
Thomas Matula
金额：
$ 67.61万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10620783
关键词：
Abscess Acoustics Acute Acute-Phase Proteins Affect Aftercare Animals Antibiotic Resistance Antibiotics Bacteria Blood Body part Caring Catheter Management Catheters Chronic Circulation Clinical Trials Connective Tissue Data Development Devices Disease Dose Drainage procedure Drug resistance Evaluation Extravasation Family suidae Fine needle aspiration biopsy Focused Ultrasound Focused Ultrasound Therapy Goals Healthcare Hematoma Histologic Hospital Charges Hospitalization Human Image In Vitro Infection Injury Length of Stay Life Lipopolysaccharides Liquid substance Measures Mechanics Methods Microbe Modality Modeling Monitor Morbidity - disease rate Needles Operative Surgical Procedures Oryctolagus cuniculus Outcome Outpatients Patients Pattern Physicians Physiologic pulse Positioning Attribute Predisposition Protocols documentation Public Health Pus Radiation Rattus Safety Specific qualifier value Stream Surgical complication Time Training Trauma Treatment Efficacy Treatment Protocols Ultrasonic Therapy Viscosity arm aspirate capsule clinically relevant contrast enhanced drug resistance development first-in-human global health healing hospital readmission image guided improved in vivo innovation pre-clinical procedural pain pus collection response risk minimization standard of care success ultrasound

项目摘要

Abscesses are infected walled-off fluid collections of pus and bacteria and represent a ubiquitous global healthcare problem. They are common sequelae of surgery, infections, or disease, and can affect any part of the body. Current standard of care includes hospitalization, antibiotics, and drainage of the abscess with a catheter. The bacteria in pus are susceptible mechanical damage with High Intensity Focused Ultrasound (HIFU), which generates localized cavitation and is a potential noninvasive means to treat abscesses. The significance of this proposal is that treatment of abscesses using ultrasound therapy under ultrasound guidance is better for the patient because it is minimally- or non-invasive, has less procedural pain, doesn’t require that the patient live for up to several weeks with a drain inserted, requires no catheter management, there is no potential tract for new infections, and no need for CT/fluoro imaging radiation. Furthermore, ultrasound treatment will reduce the need for antibiotics, and thus reduce the potential for drug resistant, life-threatening microbes.

脓肿是感染的脓液和细菌的封闭液体集合，代表了它们是手术、感染、或疾病，并且可以影响身体的任何部分。当前的护理标准包括。住院治疗、抗生素和用导管引流脓肿中的细菌。脓液很容易受到高强度聚焦超声 (HIFU) 的机械损伤，它会产生局部空化，是一种潜在的非侵入性治疗手段本提案的意义在于采用脓肿治疗方法。超声引导下的超声治疗对患者来说更好，因为它微创或无创，手术疼痛较少，不需要患者存活插入引流管可维持长达数周，无需导管管理，没有潜在的新感染途径，也不需要 CT/荧光成像辐射。此外，超声治疗将减少对抗生素的需求，从而减少潜在的耐药性、危及生命的微生物。