Together: Transforming and Translating Discovery to Improve Health

共同努力：转变和转化发现以改善健康

• 批准号: 10625179
• 负责人: DUANE A. MITCHELL
• 金额: $ 19.51万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10625179
• 关键词: Achievement; Address; Aging; Area; Catchment Area; Clinical; Clinical Informatics; Clinical Research; Clinical Sciences; Clinical Trials Network; Collaborations; Communities; Computer software; Country; Data; Development; Diagnosis; Disabled Persons; Ensure; Environment; Evaluation; Evolution; Faculty; Florida; Fostering; Funding; Genomic medicine; Geography; Goals; Good Clinical Practice; Guidelines; Health; Health Care Research; Health Priorities; Health system; Healthcare; Historically Black Colleges and Universities; Human; Informatics; Infrastructure; Institutes; Institution; Knowledge; Learning; Longevity; Medicaid; Mission; Modeling; Participant; Pathway interactions; Patient-Focused Outcomes; Performance; Phase; Policies; Population Heterogeneity; Prevention; Process; Research; Research Infrastructure; Research Personnel; Resources; Role; Rural Community; Science; Scientist; Site; Surgeon; TNFSF15 gene; Technology; Training; Translating; Translational Research; Translations; Trust; Underrepresented Minority; United States National Institutes of Health; Universities; Urban Community; Vision; Work; biomedical informatics; burden of illness; career development; catalyst; college; community engagement; evidence base; genomic data; human disease; implementation science; improved; innovation; metabolomics; new technology; next generation; novel; novel strategies; patient population; personalized medicine; precision medicine; programs; recruit; rural area; skills; success; training opportunity; translational pipeline; underserved community; urban area

Contact PD/PI: Nelson, David R Overall Abstract ABSTRACT Florida is a demographically and geographically diverse state. The University of Florida (UF) and Florida State University (FSU) CTSA hub will work within this environment to further the mission to improve human health by accelerating the translation of scientific discoveries and the implementation of evidence-based best practices for the diagnosis, treatment, prevention and cure of human diseases across the lifespan. The UF-FSU hub vision is “think globally, act locally”, offering research opportunities to underserved participants in North and North Central Florida, creating innovative career development and training opportunities, as well as collaborating across the country with the Accelerated Clinical Trials Network and PCORnet. Research strengths include precision medicine, team science, community engagement, implementation science and informatics which are conducted in diverse settings through the OneFlorida Clinical Research Consortium. The 2019-2024 period represents the next phase of evolution from creating a clinical and translational science infrastructure to enhancing the local, state and national impact of CTSI-led science. During this period, FSU will be integrated across all components and will engage six additional colleges. Hub activities will be centered around four strategic goals: (1) chart new pathways for developing the translational workforce by taking UF’s success in career development and translating this success to the FSU and historically black colleges and universities; (2) strengthen the capacity of the learning health system environment and develop transferable models for embedding translational science into the clinical enterprise by further integrating data and software, developing multi-site pilots in healthcare institutions serving unique patient populations and building on the success of the personalized medicine program to use genomics data to improve patient outcomes; (3) expand statewide collaborations and opportunities to advance a participant-centered research agenda that reflects the health priorities and diversity of the catchment area by continuing to strengthen stakeholder engagement and trust in research through the HealthStreet Program and enhance collaboration with policy stakeholders from Florida Medicaid, Florida surgeon general and others; and (4) strengthen regional and national collaborations to accelerate the collective impact of the CTSA network through continued work with ACT, PCORnet, genomic medicine, aging and metabolomics. Throughout this important work, the UF-FSU hub will remain dedicated to supporting the recruitment, retention and career development of underrepresented minority and disabled trainees and faculty. Integral to the success of the proposed work, the UF-FSU hub will further integrate health care and research in Florida guided by four keys to success: (1) organizational alignment, (2) clinical informatics, (3) clinician and stakeholder engagement, and (4) strong support from implementation and improvement science expertise. Page 415 Project Summary/Abstract Contact PD/PI: Nelson, David R Overall Narrative NARRATIVE The University of Florida (UF) and Florida State University (FSU) CTSA hub will work within the demographically and geographically diverse state of Florida to improve human health by accelerating the translation of scientific discoveries and the implementation of evidence-based best practices for the diagnosis, treatment, prevention and cure of human diseases across the lifespan. The 2019-2024 period represents the next phase of evolution from creating a clinical and translational science infrastructure to enhancing the local, state and national impact of CTSI-led science with a special emphasis on underserved and unique patient populations. Page 416

联系PD/PI：Nelson，David R 总体抽象 抽象的 佛罗里达州是一个人口统计学和地理上多元化的状态。佛罗里达大学（UF）和佛罗里达州 大学（FSU）CTSA枢纽将在这种环境中开展工作，以进一步改善人类健康的使命 加速科学发现的翻译和实施循证最佳实践 为了诊断，治疗，预防和治愈整个生命周期的人类疾病。 UF-FSU集线器 愿景是“全球思考，在本地行动”，为北部服务不足的参与者提供了研究机会 佛罗里达州北部，创造了创新的职业发展和培训机会， 与加速的临床试验网络和PCORNET合作。研究 优势包括精密医学，团队科学，社区参与，实施科学以及 通过Oneflorida临床研究联盟在潜水员环境中进行的信息。 2019-2024时期代表了创建临床和转化科学的下一阶段演变 增强CTSI领导科学的本地，州和国家影响的基础设施。在此期间，FSU 将在所有组件中集成，并将与六所大学合作。集线器活动将集中 大约四个战略目标：（1）通过服用UF的新途径来发展转化劳动力的新途径 在职业发展方面的成功，并将这一成功转化为FSU和历史悠久的黑人大学， 大学； （2）增强学习卫生系统环境的能力并发展可转移的能力 通过进一步整合数据和软件，将转化科学嵌入到临床企业中的模型， 在医疗机构中开发多站点的钢琴，为独特的患者人群提供服务，并在 个性化医学计划的成功使用基因组数据来改善患者的结果； （3）扩展 全州范围的合作和机会，以推进以参与者为中心的研究议程 通过继续加强利益相关者的参与和 通过Healthstreet计划对研究的信任，并加强与政策利益相关者的合作 佛罗里达州医疗补助，佛罗里达外科医生等； （4）强大的区域和国家合作 通过与ACT，PCORNET，基因组持续合作，加速CTSA网络对集体影响 医学，衰老和代谢组学。通过这项重要工作，UF-FSU枢纽将保持专门 支持代表性不足和残疾人的招聘，保留和职业发展 学员和教师。 UF-FSU中心将进一步整合拟议工作的成功不可或缺 佛罗里达州的护理和研究以成功的四个关键为指导：（1）组织一致性，（2）临床 信息信息，（3）临床和利益相关者的参与，以及（4）实施和 改进的科学专业知识。 第415页 项目摘要/摘要 联系PD/PI：Nelson，David R 总体叙述 叙述 佛罗里达大学（UF）和佛罗里达州立大学（FSU）CTSA HUB将在 人口统计学和地理上多样化的佛罗里达州，通过加速来改善人类健康 科学发现的翻译和实施基于证据的诊断最佳实践， 整个生命周期的治疗，预防和治愈人类疾病。 2019-2024时期代表 从创建临床和翻译的科学基础设施到增强本地， CTSI领导的科学对国家和国家的影响，特别强调了服务不足和独特的患者 人群。 第416页