Mentored Clinical Research to Improve Outcomes for Pediatric Mature B Cell Lymphoma in Uganda

指导临床研究以改善乌干达儿童成熟 B 细胞淋巴瘤的治疗结果

• 批准号: 10621584
• 负责人: CARL E ALLEN
• 金额: $ 12.5万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-25 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621584
• 关键词: AIDS related cancer; AIDS/HIV problem; Accreditation; Address; Africa South of the Sahara; African; B-Cell Lymphomas; B-Cell NonHodgkins Lymphoma; Biologic Characteristic; Botswana; Caring; Child; Childhood; Clinical; Clinical Research; Clinical Trials Network; Country; Development; Diagnosis; Disease; Educational Curriculum; Enrollment; Epidemic; Fellowship; Fellowship Program; Foundations; Goals; HIV; Health Sciences; International; Malawi; Malignant Childhood Neoplasm; Mature B-Lymphocyte; Medicine; Mentors; Mentorship; NCI Center for Cancer Research; Oncology; Outcome; Parents; Patient-Focused Outcomes; Patients; Pediatric Cancer Care Network; Pediatric Hematology; Pediatric Hospitals; Pediatric Oncologist; Physicians; Research; Research Training; Site; Standardization; Tanzania; Texas; Training; Training Programs; Treatment Protocols; Uganda; Universities; college; experience; improved; improved outcome; infection related cancer; interest; lecturer; pediatric human immunodeficiency virus; pediatrician; programs; response; risk stratification

Project Summary/Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 22-036. Outcomes for children with cancer in sub-Saharan Africa (SSA) are unacceptably poor, with fewer than 20% of those diagnosed surviving. By contrast, over 85% of children with cancer in the US survive. The HIV epidemic complicates the landscape of pediatric malignancies in SSA. In partnership with collaborators in SSA, Global HOPE aims to lay the foundation for an international collaborative clinical trial network: Pediatric HIV/AIDS & Infection-Related Malignancies Research Consortium for Sub-Saharan Africa (PARCA). The central problem faced in SSA is the significant burden of HIV-associated malignancies in children and the poor survival of these patients. Global HOPE, a program developed by Baylor College of Medicine (BCM) and Texas Children’s Hospital (TCH), addresses systemic challenges to improve patient outcomes by facilitating the development of a network of pediatric cancer care and research centers across SSA, starting with sites in Uganda, Malawi, Botswana, and Tanzania. Global HOPE focuses on capacity-building and has partnered with the internationally recognized Makerere University College of Health Sciences (MakCHS) in Uganda to create a first-of-its-kind collaborative pediatric hematology-oncology (PHO) training hub. In 2016, Makerere College of Health Sciences (MakCHS) and Global HOPE implemented the first accredited PHO physician postgraduate clinical fellowship training program in SSA. To date, 24 pediatricians from eight African countries have enrolled in this two-year PHO fellowship training Program. Fourteen graduates from the program are currently leading PHO care teams at 7 centers in 4 countries in SSA. In this application, we propose to take advantage of PARCA to support clinical research training of Dr. Anne Akullo, a recent Ugandan graduate of the MakCHS PHO fellowship program, with a mentorship team including Dr. Ruth Namazzi (Lecturer, MakCHS, and Director of the Pediatric Hematology- Oncology Fellowship Program at Makerere University, Kampala, Uganda) and clinical research experts from Houston and Uganda. The overall goal of the parent U54 is to establish a standardized multi-site strategy to deliver safe and effective disease-specific and risk-stratified care to children with mature B cell non-Hodgkin lymphoma (MB-NHL) in SSA. Dr. Akullo’s training will include personalized curriculum and mentored research experience focusing on clinical research goals of Project #3 of the PARCA U54 in Uganda: To investigate clinical and biological characteristics associated with clinical outcomes of children with MB-NHL treated on standardized PARCA treatment regimens.

项目概要/摘要 本申请是为了响应被识别为 NOT-CA- 的特殊利益通知 (NOSI) 而提交的 22-036 撒哈拉以南非洲地区 (SSA) 癌症儿童的治疗效果差得令人无法接受，不到 相比之下，美国超过 85% 的癌症儿童能够存活下来。 流行病使 SSA 的儿科恶性肿瘤情况变得复杂化 与 SSA 的合作者合作， Global HOPE 旨在为国际合作临床试验网络奠定基础：儿科艾滋病毒/艾滋病 撒哈拉以南非洲感染相关恶性肿瘤研究联盟 (PARCA) 的核心问题。 SSA 面临的问题是儿童中与艾滋病毒相关的恶性肿瘤的沉重负担以及这些儿童的生存状况不佳 Global HOPE，由贝勒医学院 (BCM) 和德克萨斯儿童医院开发的项目。 医院（TCH），通过促进发展来解决系统性挑战，以改善患者的治疗结果 整个 SSA 的儿科癌症护理和研究中心网络，从乌干达、马拉维、 Global HOPE 专注于能力建设，并与国际组织开展合作。 乌干达马凯雷雷大学健康科学学院 (MakCHS) 获得认可，创建了首个此类学院 儿科血液肿瘤学 (PHO) 合作培训中心 2016 年，麦克雷雷健康科学学院。 (MakCHS) 和 Global HOPE 实施了第一个经认可的 PHO 医师研究生临床奖学金 迄今为止，已有来自 8 个非洲国家的 24 名儿科医生参加了这个为期两年的培训项目。 PHO 奖学金培训计划。该计划的 14 名毕业生目前正在领导 PHO 护理团队。 在 SSA 4 个国家的 7 个中心，我们建议利用 PARCA 来支持临床。 Anne Akullo 博士是乌干达 MakCHS PHO 奖学金项目的新毕业生，她接受了研究培训 导师团队包括 Ruth Namazzi 博士（MakCHS 讲师兼儿科血液学主任） 乌干达坎帕拉麦克雷雷大学肿瘤学奖学金项目）和来自以下国家的临床研究专家 母公司 U54 的总体目标是建立标准化的多站点策略，以实现 为患有成熟 B 细胞非霍奇金的儿童提供安全有效的针对特定疾病和风险分层的护理 Akullo 博士的 SSA 淋巴瘤 (MB-NHL) 培训将包括个性化课程和指导研究。 专注于乌干达 PARCA U54 项目 #3 临床研究目标的经验：调查临床 以及与接受标准化治疗的 MB-NHL 儿童临床结果相关的生物学特征 PARCA 治疗方案。