RODENT IMAGING AND SPECTROSCOPY FACILITY

啮齿动物成像和光谱学设施

• 批准号: 8363894
• 负责人: KIM KANGASNIEMI
• 金额: $ 0.81万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363894
• 关键词: Aging; Anesthesia procedures; Animals; Body fat; Cardiac; Chemical Shift Imaging; Core Facility; Data; Detection; Development; Diffusion Magnetic Resonance Imaging; Diffusion weighted imaging; EFRAC; Electrocardiogram; Eligibility Determination; Funding; Grant; Image; Ischemia; Lesion; Longitudinal Studies; Magnetic Resonance; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Metabolism; Modeling; Monitor; Mus; National Center for Research Resources; Perfusion; Physiology; Principal Investigator; Protons; Rattus; Research; Research Infrastructure; Research Personnel; Resources; Rodent; Source; Spectrum Analysis; Temperature; Tissues; United States National Institutes of Health; Weight; angiogenesis; cost; heart motion; image processing; imaging modality; in vivo; instrument; lipid metabolism; research study; respiratory; tool; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Magnetic Resonance is a useful tool for in vivo studies in mouse and rat models. Two instrument were installed recently. The Mouse MRI Core Facility offers state-of-the-art magnetic resonance imaging (MRI) and proton spectroscopy (MRS) of mice and other small animals to all campus investigators. Mice can be delivered to the Research Resource, imaged under anesthesia, and returned to the investigator the same day. The facility includes a 7 Tesla horizontal-bore magnet and various physiology monitoring capabilities including ECG, respiratory gating for cardiac imaging and temperature monitoring and control throughout the imaging experiment. The facility will provide guidance for post-processing of image data and experimental planning for longitudinal studies. The mouse MR facility has developed screening protocols to optimize animal throughput including the following: MR imaging methods T1, T2, Proton Weighted Imaging, Gd-T1 weighted imaging Dynamic Contrast Enhanced MRI Diffusion-Weighted Imaging (DWI) / Diffusion-Tensor Imaging (DTI) MR Spectroscopy: Single Voxel Spectroscopy CSI-Chemical Shift Imaging Various applications that we can provide expertise in are listed here, but not limited to anatomical MR imaging, functional MR imaging and studies of tissue metabolism. Specifically the Facility has been involved with studies of Anatomical MR Imaging: * Normal development / aging * Detection/Monitoring of lesions (tumor, ischemia, etc.) * Body fat distribution Functional MR Imaging: * Perfusion (angiogenesis, etc.) * Cardiac motion/Ejection fraction * Magnetic Resonance Angiography (MRA) Tissue Metabolism: * Fat metabolites * Characterization of tumors

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 磁共振是小鼠和大鼠模型体内研究的有用工具。最近安装了两台仪器。 小鼠 MRI 核心设施为所有校园研究人员提供最先进的小鼠和其他小动物的磁共振成像 (MRI) 和质子光谱 (MRS)。小鼠可以被送到研究资源，在麻醉下成像，并在当天返回给研究者。该设施包括一个 7 特斯拉水平孔磁铁和各种生理监测功能，包括心电图、用于心脏成像的呼吸门控以及整个成像实验的温度监测和控制。该设施将为图像数据的后处理和纵向研究的实验规划提供指导。小鼠 MR 设施开发了筛选方案来优化动物吞吐量，包括以下内容： 磁共振成像方法 T1、T2、质子加权成像、Gd-T1加权成像 动态对比增强磁共振成像 扩散加权成像 (DWI) / 扩散张量成像 (DTI) 磁共振波谱分析： 单体素光谱 CSI-化学位移成像 这里列出了我们可以提供专业知识的各种应用，但不限于解剖 MR 成像、功能 MR 成像和组织代谢研究。 具体而言，该设施参与了以下研究： 解剖磁共振成像： * 正常发育/衰老 * 病变检测/监测（肿瘤、缺血等） * 身体脂肪分布 功能性磁共振成像： * 灌注（血管生成等） * 心脏运动/射血分数 * 磁共振血管造影（MRA） 组织代谢： * 脂肪代谢物 * 肿瘤的表征