RODENT IMAGING AND SPECTROSCOPY FACILITY

啮齿动物成像和光谱学设施

• 批准号: 8171643
• 负责人: KIM KANGASNIEMI
• 金额: $ 0.52万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171643
• 关键词: Aging; Anesthesia procedures; Animals; Arts; Body fat; Cardiac; Chemical Shift Imaging; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Data; Development; Diffusion Magnetic Resonance Imaging; Diffusion weighted imaging; EFRAC; Electrocardiogram; Eligibility Determination; Fatty acid glycerol esters; Funding; Grant; Image; Institution; Ischemia; Lesion; Longitudinal Studies; Magnetic Resonance; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Metabolism; Modeling; Monitor; Mus; Perfusion; Phenotype; Physiology; Protons; Rattus; Research; Research Personnel; Resources; Rodent; Source; Spectrum Analysis; Temperature; Tissues; United States National Institutes of Health; Weight; angiogenesis; heart motion; image processing; imaging modality; in vivo; instrument; research study; respiratory; tool; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Magnetic Resonance is a useful tool for in vivo studies in mouse and rat models. Two instrument were installed recently. The Mouse MRI Core Facility offers state-of-the-art magnetic resonance imaging (MRI) and proton spectroscopy (MRS) of mice and other small animals to all campus investigators. Mice can be delivered to our facility in the Clements Imaging building (NE) on the North campus, imaged under anesthesia, and returned to the investigator the same day. The facility includes a 7 Tesla horizontal-bore magnet and various physiology monitoring capabilities including ECG, respiratory gating for cardiac imaging and temperature monitoring and control throughout the imaging experiment. The facility will provide guidance for post-processing of image data and experimental planning for longitudinal studies. The mouse MR facility has developed screening protocols to optimize animal throughput including MR imaging methods: T1, T2, Proton Weighted Imaging, Gd-T1 weighted imaging Dynamic Contrast Enhanced MRI Diffusion-Weighted Imaging (DWI) / Diffusion-Tensor Imaging (DTI) MR Spectroscopy: Single Voxel Spectroscopy CSI-Chemical Shift Imaging Various applications that we can provide expertise in are listed here, but not limited to Anatomical MR Imaging: * Normal development / aging * Detection/Monitoring of lesions (tumor, ischemia, etc.) * Body fat distribution * Phenotyping Functional MR Imaging: * Perfusion (angiogenesis, etc.) * Cardiac motion/Ejection fraction * Magnetic Resonance Angiography (MRA) Tissue Metabolism: * Fat metabolites * Characterization of tumors

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 磁共振是小鼠和大鼠模型体内研究的有用工具。最近安装了两台仪器。 小鼠 MRI 核心设施为所有校园研究人员提供最先进的小鼠和其他小动物的磁共振成像 (MRI) 和质子光谱 (MRS)。小鼠可以被运送到我们位于北校区 Clements 成像大楼 (NE) 的设施，在麻醉下成像，并在当天返回给研究者。该设施包括一个 7 特斯拉水平孔磁铁和各种生理监测功能，包括心电图、用于心脏成像的呼吸门控以及整个成像实验的温度监测和控制。该设施将为图像数据的后处理和纵向研究的实验规划提供指导。小鼠 MR 设施开发了筛选方案来优化动物吞吐量，包括 磁共振成像方法： T1、T2、质子加权成像、Gd-T1加权成像 动态对比增强磁共振成像 扩散加权成像 (DWI) / 扩散张量成像 (DTI) 磁共振波谱分析： 单体素光谱 CSI-化学位移成像 此处列出了我们可以提供专业知识的各种应用，但不限于 解剖磁共振成像： * 正常发育/衰老 * 病变检测/监测（肿瘤、缺血等） * 身体脂肪分布 * 表型分析 功能性磁共振成像： * 灌注（血管生成等） * 心脏运动/射血分数 * 磁共振血管造影（MRA） 组织代谢： * 脂肪代谢物 * 肿瘤的表征