Redox Biology Center

氧化还原生物中心

基本信息

批准号：
8305266
负责人：
Donald F Becker
金额：
$ 89.43万
依托单位：
UNIVERSITY OF NEBRASKA LINCOLN
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8305266
关键词：
Address Automobile Driving Biology Biomedical Research Cardiovascular system Cataract Centers of Research Excellence Charge Collaborations Communities Complex Core Facility Disease Education and Outreach Educational Activities Extramural Activities Faculty Funding Goals Health Human Individual Institution International Lead Leadership Link Malignant Neoplasms Medical center Mentors Nebraska Nerve Degeneration Neurodegenerative Disorders Oxidation-Reduction Phase Pilot Projects Positioning Attribute Program Development Proteomics Research Research Infrastructure Research Personnel Research Project Grants Research Training Resources Services Spectrum Analysis Staging Training Training and Education Universities Vision Work bioimaging career experience fighting improved innovation insight interdisciplinary collaboration member metabolomics novel novel therapeutics outreach program programs research facility success

项目摘要

Founded in 2002 as an interdisciplinary partnership between researchers at the University of Nebraska-Lincoln (UNL) and the University of Nebraska Medical Center (UNMC), the Redox Biology Center (RBC) has grown into a nationally visible and internationally recognized program of excellence addressing fundamental questions crucial to fighting disease and improving human health. During Phases I and II, the RBC achieved its primary objective of enhancing Nebraska's biomedical research capacity through the creation of 1) a strategically linked infrastructure of strong research programs, 2) a program for mentoring talented junior faculty to independent success, 3) support for core research facilities in metabolomics/proteomics and spectroscopy/bioimaging, and 4) innovative educational activities. As a result, the RBC has developed a cadre of well-funded and productive faculty members conducting research leading to new insights in redox biology that have important implications in neurodegenerative diseases, cardiovascular health, cataracts, and cancer. Reaching the end of Phase II funding positions the RBC to move decisively toward its long-term vision of becoming a self-sustaining center of research excellence charged with providing international leadership and outstanding research resources benefiting other IDeA programs and the scientific community at large. Phase III funding will allow the RBC to attain this overarching goal by providing funds necessary to support meritorious multi-institutional research pilot projects that build the interdisciplinary collaborations necessary to maintain a strong center and compete for program project type funding while maintaining and expanding the RBC's research core facilities and promoting education and outreach. These three components - research pilot project program, core facilities (including a strong administrative core), and strong education/outreach programs, will allow the RBC to accomplish the specific aims set forth in this Phase III application: 1) Increase research capabilities, innovation, and extramural funding; 2) Strengthen research training and education in redox biology; and 3) Graduate from IDeA program funding as a self-sustainable center of research excellence in redox biology.

氧化还原生物学中心 (RBC) 成立于 2002 年，是内布拉斯加大学林肯分校 (UNL) 和内布拉斯加大学医学中心 (UNMC) 的研究人员之间的跨学科合作伙伴关系，现已发展成为全国知名、国际公认的卓越计划，致力于解决以下问题：对于对抗疾病和改善人类健康至关重要的基本问题。在第一阶段和第二阶段，RBC 实现了增强内布拉斯加州生物医学研究能力的主要目标，方法是创建 1) 一个战略性相连的强大研究项目基础设施，2) 一个指导有才华的初级教师独立成功的项目，3) 支持代谢组学/蛋白质组学和光谱学/生物成像方面的核心研究设施，以及 4) 创新教育活动。因此，加拿大皇家银行培养了一支资金雄厚、富有成效的教职人员骨干队伍，他们开展的研究为氧化还原生物学带来了新的见解，这些见解对神经退行性疾病、心血管健康、白内障和癌症具有重要影响。第二阶段资助结束后，RBC 将果断地朝着其长期愿景迈进，即成为一个自我维持的卓越研究中心，负责提供国际领导力和杰出的研究资源，造福其他 IDeA 项目和整个科学界。第三阶段的资金将使 RBC 能够实现这一总体目标，提供必要的资金来支持优秀的多机构研究试点项目，这些项目建立必要的跨学科合作，以维持一个强大的中心并竞争计划项目类型的资金，同时维持和扩大 RBC 的研究核心设施并促进教育和推广。这三个组成部分——研究试点项目计划、核心设施（包括强大的行政核心）和强大的教育/推广计划，将使 RBC 能够实现第三阶段申请中提出的具体目标： 1) 提高研究能力和创新和外部资金； 2）加强氧化还原生物学的研究培训和教育； 3) 获得 IDeA 项目资助，成为氧化还原生物学领域自我可持续发展的卓越研究中心。