Molecular Mechanisms of Disease

疾病的分子机制

• 批准号: 10410436
• 负责人: Donald F Becker
• 金额: $ 25.13万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410436
• 关键词: Disease; Molecular

This proposal seeks funding for the Molecular Mechanisms of Disease (MMoD) predoctoral training program at the University of Nebraska-Lincoln. The MMoD program addresses the NIH training focus of Cellular, Biochemical, and Molecular Sciences by providing advanced training and career development in biomedical research centered on molecular interactions and chemical transformations. The goal of the program is to develop outstanding new scientists who work in collaborative multi-disciplinary teams to research disease mechanisms using quantitative approaches that ultimately yield tangible strategies for prevention and therapy. To accomplish this goal, the program will recruit high-quality, motivated predoctoral trainees with a strong interest in the underlying causes of human disease and engage them in mentored, cutting-edge research. The MMoD program will (1) Provide a rigorous curriculum and innovative, collaborative research opportunities for six predoctoral trainees per year (NIH-supported) to become experts in the mechanistic study of human disease; (2) Cultivate an interactive training environment that enables trainees to develop professional skills in communication, leadership, proposal-writing, scholarship, entrepreneurship, and teaching; and 3) Build a cohort of trainees from diverse perspectives that have the knowledge and ability to work at the crossroads of different disciplines in their future careers as PhD scientists. The MMoD program provides collaborative training in mechanistic disease research in the areas of molecular signaling, metabolic integrity, oxidative stress and redox biology, and disease microenvironment. The MMoD mentoring team spans seven departments and three colleges and includes 32 faculty members from early-stage to established investigators with strong histories in biomedical research funding and graduate student mentoring. Trainees will conduct four research rotations in year 1 before choosing a faculty mentor, and will be supported by NIH T32 funding for up to two years beginning in the second year of their five-year program. Selection of new trainees for NIH support will be competitive, based on strong academic record, research progress and potential, and an original collaborative proposal bridging disciplinary boundaries for innovative thesis research. Trainees will take a flexible core curriculum that includes a course on Metabolic Function and Dysfunction, and a quantitative biology course and two macromolecules courses from an approved core. Though these courses and MMoD training modules, students will acquire skills in evidence-based education, quantitative and critical analysis, and, rigor and reproducibility in research. They will also have opportunities for professional experiences related to intellectual property and the pharmaceutical industry in preparation for potential career options. The MMoD program provides a framework that enables trainees to gain a broad knowledge base; actively seek research collaborations; produce an outstanding record of original published research; and develop presentation, proposal-writing, and leadership skills that will position them for future excellence as independent researchers.

该提案为疾病分子机制（MMoD）博士前培训项目寻求资金 内布拉斯加大学林肯分校。 MMoD 计划解决了 NIH 的细胞培训重点， 生物化学和分子科学，提供生物医学领域的高级培训和职业发展 研究集中于分子相互作用和化学转化。该计划的目标是 培养在多学科协作团队中研究疾病的杰出新科学家 使用定量方法的机制，最终产生切实的预防和治疗策略。 为实现这一目标，该项目将招募高素质、积极进取、具有较强实力的博士前培训生。 对人类疾病的根本原因感兴趣，并让他们参与指导的前沿研究。这 MMoD 项目将 (1) 提供严格的课程和创新的合作研究机会 每年六名博士前培训生（NIH 支持）成为人类机制研究的专家 疾病; （二）营造互动式的培训环境，使学员能够发展专业技能 沟通、领导力、提案撰写、学术、创业和教学； 3）建立一个 一群来自不同角度的学员，拥有在十字路口工作的知识和能力 作为博士科学家，他们在未来的职业生涯中会选择不同的学科。 MMoD 计划提供协作 分子信号传导、代谢完整性、氧化等领域的机械疾病研究培训 应激和氧化还原生物学，以及疾病微环境。 MMoD 指导团队由七人组成 部门和三个学院，包括 32 名从早期到成熟研究人员的教职人员 在生物医学研究资助和研究生指导方面拥有悠久的历史。学员将进行四 在选择导师之前的第一年进行研究轮换，并将获得 NIH T32 资金的支持 从五年计划的第二年开始的两年。选择新学员以获得 NIH 支持 基于良好的学术记录、研究进展和潜力以及原创性，将具有竞争力 协作提案弥合创新论文研究的学科界限。学员将采取 灵活的核心课程，包括代谢功能和功能障碍课程以及定量课程 生物学课程和两门来自批准核心的大分子课程。虽然这些课程和 MMoD 培训模块，学生将获得循证教育、定量和批判性分析的技能， 研究的严谨性和可重复性。他们还将有机会获得相关的专业经验 知识产权和制药行业，为潜在的职业选择做好准备。大型多人在线游戏 计划提供了一个框架，使受训者能够获得广泛的知识基础；积极寻求研究 合作；产生原始发表研究的杰出记录；并制定演示文稿， 提案撰写和领导技能将使他们成为未来优秀的独立研究人员。