Chemical Biology of Infectious Disease

传染病化学生物学

基本信息

批准号：
10270499
负责人：
P Scott Hefty
金额：
$ 226.79万
依托单位：
UNIVERSITY OF KANSAS LAWRENCE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-15 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10270499
关键词：
Address Animals Area Biological Biological Models Biology Centers of Research Excellence Chemicals Chemistry Chemotherapy-Oncologic Procedure Collaborations Communicable Diseases Communities Core Facility Coupled Development Faculty Infectious Agent Infrastructure Institution Intervention Investments Kansas Lead Mentors Mentorship Microbiology Modernization Organism Pathway interactions Pharmaceutical Chemistry Pharmacologic Substance Pharmacology Phase Pilot Projects Principal Investigator Process Proteomics Public Health Research Research Personnel Research Project Grants Resistance Resources Science Scientist Series United States National Institutes of Health Universities Validation Work base design drug discovery effective therapy expectation experience high throughput screening infectious disease treatment innovation member multidisciplinary novel outreach prevent professor programs recruit research facility success tool

项目摘要

PROJECT SUMMARY The development of new chemotherapeutic approaches for the treatment of infectious disease is, by acclamation, one of the preeminent challenges of modern biomedical science. Contributing causes include the emergence of organisms resistant to existing therapies, the reemergence of infectious agents once thought vanquished, and the spread of infectious diseases lacking effective treatments. Confronting these public health challenges requires coordinated and comprehensive efforts from nearly every relevant area of biomedical science from microbiology to pharmacology to medicinal chemistry. This Phase II proposal is designed to strengthen and enhance the investments and infrastructure established in Phase I for the Center for Chemical Biology of Infectious Diseases (CBID). This will be accomplished through thorough selection and successful mentoring of Research Project investigators, enabling research opportunities and access to core resources through Pilot Project support, recruitment of outstanding new faculty scientists, and substantially increasing the user base of Research Core facilities with a focus on long-term sustainability. Together, the CBID Center will continue to address critical gaps and enable researchers at the University of Kansas (KU) and associated institutions to apply these tools to better understand and potentially prevent infectious diseases.

项目摘要开发用于治疗传染病的新化学治疗方法是 Acclamation是现代生物医学科学的杰出挑战之一。贡献原因包括有机体的出现对现有疗法有抵抗力，感染力的再生曾经想到被征服，以及缺乏有效治疗的传染病的传播。面对这些公共卫生挑战需要几乎每个相关领域的生物医学领域的协调和全面的努力从微生物学到药理学再到药物化学的科学。该第二阶段提案旨在加强和增强I阶段化学中心中建立的投资和基础设施传染病的生物学（CBID）。这将通过彻底的选择和成功来实现指导研究项目调查人员，为研究机会并获得核心资源通过试点项目支持，招募杰出的新教师科学家，并大大增加了研究核心设施的用户群，重点是长期可持续性。一起，CBID中心将继续解决堪萨斯大学（KU）的关键差距，并使研究人员和关联应用这些工具以更好地理解和潜在预防传染病的机构。