Center for Childhood Obesity Prevention

儿童肥胖预防中心

• 批准号: 10270950
• 负责人: JUDITH Lynne WEBER
• 金额: $ 233.87万
• 依托单位: ARKANSAS CHILDREN'S HOSPITAL RES INST
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10270950
• 关键词: 4 year old; Address; Adolescent; Adolescent obesity; Arkansas; Asthma; Behavior; Biomedical Research; Burn injury; Caring; Child; Child Health; Clinical; Collaborations; Communities; Complex; Contracts; Diabetes Mellitus; Dietary Proteins; Disease; Education; Emotional; Energy Metabolism; Ensure; Environment; Epidemiology; Evidence based practice; Food; Goals; Health; Hypertension; Insulin Resistance; Intervention; Investments; Leadership; Link; Low income; Maintenance; Malignant Neoplasms; Mentors; Metabolic; Mitochondria; Modeling; Muscle function; Obesity; Outcome; Overweight; Pathway interactions; Phase; Phenotype; Physical activity; Pilot Projects; Plant Roots; Policies; Population; Prevalence; Prevention strategy; Problem behavior; Procedures; Process; Program Development; Protons; Public Health; Regulation; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Rights; Role; Sampling; School-Age Population; Schools; Science; Scientist; Secure; Series; Sleep Disorders; Strategic Planning; System; Teacher Professional Development; Testing; Time; Training; Training Programs; United States; United States National Institutes of Health; Work; Youth; base; cardiorespiratory fitness; career development; comorbidity; dietary; disorder prevention; energy balance; evidence base; exercise intensity; fitness; fundamental research; improved; innovation; metabolic rate; multidisciplinary; non-alcoholic fatty liver disease; obesity in children; obesity prevention; operation; overweight child; programs; protein intake; recruit; research and development; research facility; severe burns; social; translational pipeline

PROJECT SUMMARY The goal of this application is to further develop an integrated, multidisciplinary and translational Center for Childhood Obesity Prevention (CCOP) that will be sustained within the Arkansas Children’s Research Institute. Childhood obesity is a national public health threat that is disproportionately worse in Arkansas. In the United States, nearly 1 in 5 school age youth have obesity (1). Among school-age youth in Arkansas, 23% have obesity and 17% are classified as overweight (2). Further, the prevalence of hypertension (4-6), and other obesity-related co-morbidities, have increased dramatically over the last two decades. Additionally, obesity and obesity-promoting behaviors are also linked to a variety of cancers (16). To address this complex problem, a group of emerging scientists recruited in Phase 1 will continue to build their collaborative work in elucidating causes, and testing interventions, to stop the rise and ultimately reduce the prevalence of child overweight and obesity and corresponding comorbidities. In order to establish a broad-based, multi-disciplinary disease prevention center, rooted in a team science approach, projects span the full translational continuum, bringing together research in complex disease origins, epidemiology, and social systems. Ongoing recruitment of additional research project leaders and pilot study investigators will continue to build a critical mass of scientists focused on building the base of evidence for strategies to address the childhood obesity crisis and improve child health. Specific Aim 1: Further enhance the research infrastructure established in Phase 1 to support the Center. Critical institutional support and strong collaborations with multiple key institutional and community partners have been established, and will continue to be enhanced, to provide junior investigators’ access to state-of-the-art biomedical research facilities and resources to pursue inquiry focused on the theme of childhood obesity prevention. Specific Aim 2: Continue to build on the successful faculty development program implemented in Phase 1. The career development training program established in Phase 1 in partnership with the UAMS CTSA’s Research Fundamentals program will continue to be strengthened. A “best practices” senior mentoring program combines a Senior Mentor Rights and Responsibilities contract with guidance from a Senior Mentoring Leadership Team approach. Specific Aim 3: Ensure robust operations and pathway to sustainability for the Center for Childhood Obesity Prevention. Comprehensive operational procedures for managing the Center’s fiscal, regulatory, project development, and research core viability processes were established, and will continue to be strengthened. Significant institutional investment has been secured, and will be leveraged to ensure long term sustainability of the Center.

项目概要 该应用程序的目标是进一步发展一个综合性、多学科和转化中心 儿童肥胖预防 (CCOP) 将在阿肯色州儿童基金会内持续开展 研究所指出，儿童肥胖是一种全国性的公共卫生威胁，在以下国家尤为严重。 在美国阿肯色州，近五分之一的学龄青少年患有肥胖症 (1)。 阿肯色州 23% 的人肥胖，17% 的人超重 (2)。 (4-6) 以及其他与肥胖相关的并发症在过去二十年中急剧增加。 此外，肥胖和促进肥胖的行为也与多种癌症有关 (16)。 对于这个复杂的问题，第一阶段招募的一群新兴科学家将继续建立他们的 共同努力阐明原因并测试干预措施，以阻止上升并最终减少 儿童超重和肥胖的患病率以及相应的合并症。 为了建立一个基础广泛、多学科、植根于团队的疾病预防中心 科学方法，项目跨越整个转化连续体，将复杂的研究汇集在一起 疾病起源、流行病学和社会系统正在招募更多的研究项目负责人。 试点研究人员将继续培养足够数量的科学家，专注于建立基础 解决儿童肥胖危机和改善儿童健康的战略证据。 具体目标1：进一步加强第一阶段建立的研究基础设施，以支持 中心的关键机构支持以及与多个关键机构和社区的强有力合作。 合作伙伴已经建立并将继续得到加强，为初级研究人员提供获得信息的机会 最先进的生物医学研究设施和资源，以进行重点研究的主题 儿童肥胖的预防。 具体目标 2：继续以成功实施的教师发展计划为基础 第一阶段。第一阶段与 UAMS 合作建立的职业发展培训计划 CTSA 的研究基础计划将继续加强“最佳实践”高级指导。 计划结合了高级导师的权利和责任合同以及高级导师的指导 指导领导团队的方法。 具体目标 3：确保中心稳健运营并实现可持续发展 儿童肥胖预防管理中心的财务、 监管、项目开发和研究核心可行性流程已经建立，并将继续 已获得大量机构投资，并将加以利用以确保长期发展。 中心的长期可持续性。