Integrated Membrane Program (IMP)

综合膜计划（IMP）

• 批准号: 10270422
• 负责人: Todd B Reynolds
• 金额: $ 14.63万
• 依托单位: UNIVERSITY OF TENNESSEE KNOXVILLE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10270422
• 关键词: Membrane; programs

Project Summary The Integrated Membrane Program (IMP) T32 Training Grant will address an important gap that exists in the biomedical workforce of the future. The IMP will address research training needs in the area of biological membranes (biomembranes), which are crucially important structures that define and separate physical spaces within and outside cells, making them fundamental to life on Earth. However, biomembranes do much more, as they control intracellular signaling and development, are required for energy production, mediate drug delivery and drug resistance, are essential for making essential cellular macromolecules, and affect growth and movement, which impacts cancer and other diseases. Thus, understanding biomembranes impacts many critical areas of biomedical research. Biomembranes research as a field covers the mechanisms by which membranes are synthesized from their constituent proteins, lipids, and carbohydrates, are trafficked and changed in response to the environment, and then in turn affect the many processes described above. Additionally, human manipulation of natural and synthetic membranes can be harnessed for myriad applications from computation to energy production to the development of new materials. Multiple fields and disciplines including biology, physics, chemistry, engineering, and computational science have applicability to biomembranes, but increasingly, there is a need for scientists who can bridge these fields and integrate different approaches to meet the next generation of research challenges. The University of Tennessee, Knoxville (UT) has unique breadth and depth in biomembrane research, with federally funded, collaborative researchers spanning 7 departments in 4 colleges. The 32 faculty in the IMP mentor pool have a shared commitment to establish a training program that will span fields and disciplines. These scientists are already working together through the establishment of the UT- facilitated Community of Scholars (COS) for Biomembranes, which has met 2-3 times every semester since 2018, and where many students have presented seminars on their research. The shared research, training, and overall momentum that exists within the Biomembranes COS forms the foundation for the IMP T32. Multiple investigators within the Biomembranes COS have ongoing collaborations that span fields and disciplines, and have co-mentored graduate students. The establishment of a T32-based IMP will formalize this integrated approach to training so these students can advance fundamental knowledge of biomembranes and apply this knowledge to improve human health. In addition to integrated training in science, the IMP will further enhance training in responsible conduct of research, reproducibility, and diversity and inclusion, which are already being addressed at UT, but will be formalized under this NIH T32 mechanism.

项目摘要 综合膜计划（IMP）T32培训赠款将解决一个重要的差距 未来的生物医学劳动力。 IMP将满足生物学领域的研究培训需求 膜（生物膜）是至关重要的结构，定义和分开物理空间 内部和外部细胞，使其成为地球生命的基础。但是，生物膜做得更多，因为 他们控制细胞内信号传导和发育，是能源生产所必需的，介导药物输送 和耐药性，对于制造必要的细胞大分子和影响生长和 运动，影响癌症和其他疾病。因此，理解生物膜会影响许多关键 生物医学研究领域。生物膜研究涵盖了膜的机制 从其成分蛋白，脂质和碳水化合物中合成，被贩运并改变以响应 到环境，然后影响上述许多过程。另外，人类 可以利用对自然和合成膜的操纵来用于从计算到无数的应用 能源生产新材料的开发。多个领域和学科，包括生物学，物理学， 化学，工程和计算科学对生物膜具有适用性，但越来越多 是需要桥接这些领域并整合不同方法以满足下一代的科学家 研究挑战。田纳西大学诺克斯维尔大学（UT）具有独特的广度和深度 生物膜研究，由联邦资助的合作研究人员跨越了4所大学的7个部门。 IMP导师池中的32位教师有共同的承诺，以建立一个将跨越的培训计划 领域和学科。这些科学家已经通过建立UT- 促进生物膜的学者社区（COS），自从以来每学期都有2-3次 2018年，许多学生都为他们的研究提供了研讨会。共同的研究，培训和 生物膜内部存在的总体动力构成了IMP T32的基础。多种的 生物膜中的调查人员进行了持续的合作，可以跨越领域和学科，并且 有联合研究生。建立基于T32的IMP将正式化这一综合 培训方法使这些学生可以提高生物膜的基本知识并应用此 知识以改善人类健康。除了科学的综合培训外，IMP还将进一步增强 在负责任的研究，可重复性以及多样性和包容性的培训中 在UT上解决，但将根据这种NIH T32机制进行形式化。