MUSCLE: MUsculoSkeletal Clinical Learning Experience Transdisciplinary Musculoskeletal Research Training Program

肌肉：肌肉骨骼临床学习体验跨学科肌肉骨骼研究培训计划

• 批准号: 10612446
• 负责人: J. Kent Leach
• 金额: $ 18.36万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612446
• 关键词: Clinical; Learning; Musculoskeletal; Research Training; Training Programs; experience; Clinical; Learning; Musculoskeletal; Research Training; Training Programs; experience

PROJECT SUMMARY Within the United States, musculoskeletal disease affects more than half of people aged 18 and over and nearly three out of four aged 65 and over. The impact of musculoskeletal disease will become even more pronounced with the increase in the aging population. Mechanistic research that is integrated with clinical need is imperative to develop new treatment approaches, yet there is a stark mismatch between funding levels in musculoskeletal research and its financial and personal toll on our healthcare system. Our institution and the orthopaedic community, due to a lack of integrated programs, have struggled to overcome the disconnect between mechanistic research in musculoskeletal health and effective translation into the clinic. We developed the MUsculoSkeletal Clinical Learning Experience (MUSCLE) T32 Transdisciplinary Training Program at UC Davis to meet this need. The overall objective of this training program is to increase the number of biomedical scientists trained in musculoskeletal-related research with an emphasis on understanding clinical needs and obstacles. A novel aspect of our program is the frequent interaction and integration of premier musculoskeletal research faculty with leading clinicians at UC Davis, coupled with co-mentorship by mechanistic and clinical scientists, providing an elite training experience for future researchers in musculoskeletal health. The objective of the MUSCLE T32 is to provide two years of funded, transdisciplinary, integrated research training to develop predoctoral students into researchers capable of solving issues relevant to the understanding, prevention, and treatment of musculoskeletal diseases. This unique and integrated format benefits from co-directorship by mechanistic and clinical researchers alike, coordinating a select group of exemplary engineers, biologists, materials scientists, veterinarians, and human clinicians to co-mentor our students, in combination with a carefully designed, flexible curriculum that provides in-depth training for predoctoral students in musculoskeletal health research. With the recruitment of 3 new participants each year, trainees will partake in several clinical immersive experiences, where they will discuss the needs of the clinician and how research advancements can address these challenges. Our program emphasizes fundamentals in research techniques that broaden research training at the bench with quantitative skills, provides opportunities for public speaking and outreach, builds proposal writing skills, provides a range of enriching extracurricular opportunities, and integrates medicine and science/engineering throughout all years of training. Defined oversight mechanisms are in place to track the progress of the 15 trainees throughout the program. By training in an environment and culture that gives strong interdisciplinary support for mechanistic research and frequent clinical engagement, there is a significant probability that the trainees will sustain an interest in musculoskeletal health research over their careers.

项目摘要 在美国，肌肉骨骼疾病会影响一半以上18岁以上的人 四分之三的65岁及以上。肌肉骨骼疾病的影响将变得更加明显 随着老龄化人口的增加。与临床需求相结合的机械研究是必须的 为了开发新的治疗方法，但是肌肉骨骼的资金水平之间存在明显的不匹配 研究及其对我们的医疗保健系统的财务和个人损失。我们的机构和骨科 由于缺乏集成计划，社区一直在努力克服脱节 肌肉骨骼健康和有效转化为诊所的机械研究。我们开发了 加州大学戴维斯分校的肌肉骨骼临床学习经验（肌肉）T32跨学科培训计划 满足这种需求。该培训计划的总体目标是增加生物医学科学家的数量 接受了与肌肉骨骼相关的研究的培训，重点是了解临床需求和障碍。一个 我们计划的新方面是主要的肌肉骨骼研究的频繁相互作用和整合 加州大学戴维斯分校的领先临床医生的教职 为未来的肌肉骨骼健康研究人员提供精英培训经验。目的 肌肉T32将提供两年的资助，跨学科的综合研究培训，以发展 专业的学生进入能够解决与理解，预防和 治疗肌肉骨骼疾病。这种独特而集成的格式受益于联合导演 机械和临床研究人员都可以协调一组示例性的工程师，生物学家， 材料科学家，兽医和人类临床医生将我们的学生共同授权我们的学生 精心设计，灵活的课程，为肌肉骨骼中的专业学生提供深入的培训 健康研究。每年招募3名新参与者，学员将参加几个临床 沉浸式体验，他们将在其中讨论临床医生的需求以及研究进步如何 应对这些挑战。我们的计划强调了扩大研究的研究技术的基础知识 以定量技能在替补席上培训，为公开演讲和宣传提供机会，建造 建议写作技巧，提供一系列丰富的课外机会，并整合医学和 在所有年份的培训中，科学/工程学。定义的监督机制已适当以跟踪 整个计划的15名学员的进步。通过在能够强大的环境和文化中训练 跨学科支持机械研究和频繁的临床参与，有重要的 学员将对肌肉骨骼健康研究对其职业产生兴趣的可能性。