Midcareer Investigator Award in Patient-Oriented Research in the Microbiome and Lung Disease

微生物组和肺部疾病以患者为导向的研究中的职业生涯中期研究员奖

基本信息

批准号：
10612105
负责人：
Robert Pickett Dickson
金额：
$ 12.5万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10612105
关键词：
2019-nCoV Acute American Antibiotics Area Attenuated Vaccines Award Bacterial DNA Biological Bleomycin Blood Blood specimen COVID-19 COVID-19 patient Career Mobility Cells Cessation of life Clinical Collaborations Communication Communities Critical Care Critical Illness Dedications Development Development Plans Disease Education Faculty Fellowship Program Functional disorder Goals Heterogeneity Hospitalization Human Hypoxemic Respiratory Failure Immune Immune response Immunity Immunologics Immunology Immunophenotyping Influenza Influenza vaccination Intestinal permeability Journals Leadership Leukocytes Lung Lung diseases Manuscripts Measurement Measures Mechanical ventilation Medical Students Medicine Mentors Mentorship Metabolic Metagenomics Methodology Michigan Microbiology Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Morbidity - disease rate Multiple Organ Failure Nasopharynx Nose Organ Oropharyngeal Outcome Oxygen Pathogenesis Patients Persons Pharyngeal structure Phenotype Physicians Plasma Predisposition Prevention Proteomics Publications Rectum Reporting Research Research Methodology Research Personnel Research Support Risk Factors Role SARS coronavirus SARS-CoV-2 infection Scientist Secure Severities Source Specimen Supervision Swab Symptoms Therapeutic Time Training Training Programs Translational Research Universities Upper respiratory tract Variant Ventilator Viral Respiratory Tract Infection Virus Diseases career community living comorbidity density experimental study gut bacteria gut microbiota healthy volunteer human model immune activation indexing influenza infection interest lung injury lung microbiota metabolomics microbial community microbiome microbiome research microbiota mid-career faculty modifiable risk mortality multidisciplinary next generation novel oropharyngeal swab participant enrollment patient oriented patient oriented research patient variability pharyngeal swab prognostic programs prospective recruit rectal research and development respiratory respiratory microbiota respiratory virus responsible research conduct severe COVID-19 skills therapeutic target timeline translational medicine

项目摘要

PROJECT SUMMARY/ABSTRACT Dr. Dickson is an Associate Professor in Medicine (Pulmonary & Critical Care Medicine) and Microbiology & Immunology at the University of Michigan. He is a physician-scientist with expertise in the microbiome’s role in critical illness and lung disease, and has an established track record of high-impact patient-oriented research. He has demonstrated his potential to excel in mentorship via successful supervision of research trainees, as Associate Program Director for Research for the University of Michigan’s highly successful Pulmonary & Critical Care Medicine Fellowship Program, and as Associate Program Director for his Division’s T32 training program (Multidisciplinary Training in Lung Disease). Dr. Dickson seeks this K24 Mid-Career Investigator Award to continue his successful research program while dedicating significant time to mentoring the next generation of aspiring scientists, including medical students, residents, clinical and post-doctorate fellows, and junior faculty. The goals of this proposal are to 1) support the candidate’s continued impact as a mentor, 2) secure protected time for coursework to acquire new mentorship and leadership skills, 3) and equip the candidate to recruit mentees interested in patient-oriented research. In his proposed research and development plan, Dr. Dickson will tailor a mentoring plan to each trainee consisting of one-on-one mentoring sessions, formal educational opportunities in research methods and the responsible conduct of research, and collaborations with colleagues with complementary expertise and educational commitments. Each candidate will have a tailored timeline towards career advancement, including the regular publication of original research manuscripts. Dr. Dickson will provide mentorship not only in methodologic expertise but also in the critical skills of scientific communication and leadership. Dr. Dickson’s scientific aims for this project will extend his existing research into a new area of immediate patient-oriented importance: the role of the microbiome in viral respiratory infections. The first aim will be to determine if respiratory and gut bacteria (characterized via pharyngeal swabs, rectal swabs, and by the diversity and burden of gut bacterial DNA detectable in blood specimens) explains patient heterogeneity in susceptibility to severe COVID-19 disease. The second aim will be to determine how acute influenza infection and vaccination (administered in a controlled experiment of healthy volunteers) alters upper respiratory tract microbiota, and how this explains variation in systemic immune response. These aims leverage 1) existing biospecimens already available to Dr. Dickson, 2) a unique controlled experimental human model of acute influenza infection, and 3) Dr. Dickson’s broad research portfolio characterizing the role of microbiota (both respiratory and gut) in the pathogenesis of critical illness. Dr. Dickson is at an ideal stage of his career to take advantage of a K24 award, and is deeply committed to an investigative career in patient-oriented research as well as developing the next generation of investigators.

项目概要/摘要迪克森博士是医学（肺与重症监护医学）和微生物学副教授他是密歇根大学免疫学专业的医学科学家，在微生物组的作用方面拥有丰富的专业知识。危重疾病和肺部疾病，并拥有以患者为导向的高影响力研究的良好记录。他通过对研究实习生的成功监督，展示了自己在指导方面表现出色的潜力，密歇根大学非常成功的肺与疾病研究项目副主任重症监护医学奖学金计划，并担任其部门 T32 培训的副计划主任计划（肺部疾病多学科培训）。 Dickson 博士寻求获得 K24 职业生涯中期研究员奖，以继续他成功的研究计划，同时投入大量时间指导下一代有抱负的科学家，包括医学生，住院医师、临床和博士后研究员以及初级教师本提案的目标是 1) 支持候选人作为导师的持续影响力，2）确保有受保护的时间进行课程作业以获得新的指导和领导技能，3) 并使候选人能够招募对以患者为导向的研究感兴趣的受训者。在他提出的研发计划中，迪克森博士将为每位学员量身定制指导计划包括一对一的指导课程、研究方法的正式教育机会以及负责任地进行研究，并与具有互补专业知识的同事合作每位候选人都会有一个量身定制的职业发展时间表，包括迪克森博士定期出版原始研究手稿不仅会在以下方面提供指导。方法论方面的专业知识，还包括科学沟通和领导力的关键技能。迪克森博士对该项目的科学目标是将他现有的研究扩展到一个新的直接领域以患者为中心的重要性：微生物组在病毒性呼吸道感染中的作用。确定呼吸道和肠道细菌（通过咽拭子、直肠拭子和血液样本中可检测到的肠道细菌 DNA 的多样性和负担）解释了患者的异质性第二个目标是确定对严重 COVID-19 疾病的易感性。疫苗接种（在健康志愿者的对照实验中进行）会改变上呼吸道微生物群，以及如何解释系统免疫反应的变化这些目标利用 1) 现有的。 Dickson 博士已经获得了生物样本，2) 一种独特的急性急性受控实验人体模型流感感染，以及 3) Dickson 博士广泛的研究组合描述了微生物群的作用（两者呼吸道和肠道）在危重疾病的发病机制中。 Dickson 博士正处于职业生涯的理想阶段，可以利用 K24 奖项，并坚定地致力于以患者为导向的研究以及培养下一代研究人员的调查生涯。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Immunocompromised Host Pneumonia: Definitions and Diagnostic Criteria: An Official American Thoracic Society Workshop Report.

DOI：
10.1513/annalsats.202212-1019st
发表时间：
2023-03
期刊：
Annals of the American Thoracic Society
影响因子：
8.3
作者：
通讯作者：

Portable Breath-Based Volatile Organic Compound Monitoring for the Detection of COVID-19 During the Circulation of the SARS-CoV-2 Delta Variant and the Transition to the SARS-CoV-2 Omicron Variant.

DOI：
10.1001/jamanetworkopen.2023.0982
发表时间：
2023-02-01
期刊：
JAMA NETWORK OPEN
影响因子：
13.8
作者：
Sharma, Ruchi;Zang, Wenzhe;Tabartehfarahani, Ali;Lam, Andres;Huang, Xiaheng;Sivakumar, Anjali Devi;Thota, Chandrakalavathi;Yang, Shuo;Dickson, Robert P.;Sjoding, MichaelW.;Bisco, Erin;Mahmood, Carmen Colmenero;Diaz, Kristen Machado;Sautter, Nicholas;Ansari, Sardar;Ward, Kevin R.;Fan, Xudong
通讯作者：
Fan, Xudong

Minimizing caging effects in murine lung microbiome studies.

最大限度地减少小鼠肺微生物组研究中的笼养效应。