Admin Core

管理核心

基本信息

批准号：
10598770
负责人：
Charles Wood
金额：
$ 28.51万
依托单位：
LSU HEALTH SCIENCES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10598770
关键词：
AIDS related cancer Address Africa Africa South of the Sahara African Biological Markers Cancer Center Caring Chronic Disease Climate Clinical Collaborations Communication Complex Country Detection Development Diagnosis Diagnostic Disease Ensure Environment Goals Group Meetings HIV HIV-1 Health Sciences Hospitals Human Herpesvirus 8 Immune response Immunologics Immunosuppression Individual Information Dissemination Infrastructure Institution International Kaposi Sarcoma Leadership Location Louisiana Malignant Neoplasms Mission Oceans Outcome Outcomes Research Pathogenesis Persons Pilot Projects Policies Prevention Process Research Research Activity Research Infrastructure Research Project Grants Resource Sharing Resources Series Tanzania Teaching Hospitals Technology Tissues Training United States United States National Institutes of Health Universities Viral Viral reservoir Virus Latency Work Zambia anticancer research antiretroviral therapy career development data dissemination data integration data management data sharing design experience improved meetings metabolomics prevent programs success synergism

项目摘要

A multi-institutional, international, and integrated endeavor, the “KS in the Era of ART in Africa Program (KEAAP)” will leverage the research and training expertise of collaborating institutions from the U.S. and two African countries: the Louisiana State University Health Sciences Center-New Orleans (LSUHSC-NO), the Cancer Diseases Hospital (CDH) and the University Teaching Hospitals (UTH) of Zambia, and the Ocean Road Cancer Institute (ORCI) in Dar es Salaam, Tanzania to form an HIV-Associated Malignancy Research Center (HAMRC) that focuses on the research gaps of the Kaposi sarcoma (KS) disease. Building on the success of their previous collaborations, these institutions will synergize their efforts under one overarching research theme that focuses on the KS disease spectrum, from detection, to care and outcomes, to deciphering KS pathogenesis and immune response. The immediate goal is to 1) implement a program to better integrate KS diagnostic, clinical and research activities within the HIV-1 care and treatment networks in both countries; 2) define stage- and treatment-associated immunologic and metabolomics biomarkers across the spectrum of KS disease presentation; and 3) define the magnitude and breadth of Kaposi sarcoma herpesvirus (KSHV) latent viral reservoirs in tissues of KSHV infected people living with HIV, so that these reservoirs could be targeted for prevention of viral reactivation to prevent KS. To achieve this goal and promote synergy and coordination across partnering institutions, KEAAP will establish an Administrative Core, based at LSUHSC-NO with satellite locations at UTH/CDH, and ORCI, that will provide the administrative support needed to ensure that KEAAP’s three research projects, Shared Resource Core (Data Management and Integration Core), and Career Development Core can accomplish their individual and collective goals while functioning in an integrated and coordinated manner. The Administrative Core will pursue four specific aims. 1) Provide the administrative expertise and resources necessary to support the consortium’s research projects and cores and the pilot projects to accomplish their goals and specific aims. 2) Implement a consortium-wide series of operational processes designed to create a collaborative research environment, promote data sharing and dissemination of results, and build capacity for increased self-sufficiency at cancer research institutions in Tanzania and Zambia. 3) Provide communications infrastructure to engage key stakeholders, to promote the consortium, and disseminate information and research outcomes that will inform healthy policy changes locally, and globally. The organization of the Administrative Core is designed to be responsive, inclusive, and robust – attributes that are essential to address the broad mission and complex relationships within KEAAP, among collaborating institutions, and with NIH. The core will focus on meeting the needs of the collaborators in a climate of rapidly changing scientific and technological advances in order to promote a sustainable consortium with vibrant research programs that work toward the reduction of cancer in sub-Saharan Africa.

“非洲艺术时代的 KS 计划”是一项多机构、国际和综合性的努力 (KEAAP)”将利用美国和两个合作机构的研究和培训专业知识非洲国家：路易斯安那州立大学健康科学中心-新奥尔良 (LSUHSC-NO)、赞比亚癌症疾病医院 (CDH) 和大学教学医院 (UTH) 以及海洋坦桑尼亚达累斯萨拉姆道路癌症研究所 (ORCI) 将组建艾滋病毒相关恶性肿瘤研究中心中心（HAMRC）专注于卡波西肉瘤（KS）疾病的研究空白。继之前的合作取得成功后，这些机构将在一个总体框架下协同努力研究主题侧重于 KS 疾病谱，从检测到护理和结果，再到破译 KS 发病机制和免疫反应近期目标是 1) 实施一项计划更好地将 KS 诊断、临床和研究活动纳入 HIV-1 护理和治疗网络两国；2) 定义与阶段和治疗相关的免疫学和代谢组学生物标志物 KS 疾病的表现范围；3) 定义卡波西肉瘤的大小和范围疱疹病毒 (KSHV) 潜伏在 KSHV 组织中的病毒库感染了 HIV 感染者，因此这些可以针对病毒储存库进行针对性预防，以预防 KS 的发生并促进这一目标。合作机构之间的协同和协调，KEAAP 将建立一个行政核心，总部设在 LSUHSC-NO 在 UTH/CDH 和 ORCI 设有卫星位置，将提供行政支持需要确保 KEAAP 的三个研究项目：共享资源核心（数据管理和整合核心）和职业发展核心可以实现他们的个人和集体目标，同时行政核心以综合协调的方式运作，将实现四个具体目标。 1) 提供支持联盟研究项目所需的管理专业知识和资源以及核心和试点项目，以实现其目标和具体目标 2) 在联盟范围内实施。旨在创建协作研究环境、促进数据共享的一系列操作流程和传播结果，并建设提高癌症研究机构自给自足的能力坦桑尼亚和赞比亚 3) 提供通信基础设施以吸引主要利益相关者，以促进联盟，并传播信息和研究成果，为当地的健康政策变化提供信息，行政核心的组织旨在响应迅速、包容且稳健—— 这些属性对于解决 KEAAP 内的广泛使命和复杂关系至关重要，其中合作机构，以及与 NIH 的合作，其核心将侧重于满足合作者的需求。快速变化的科学技术进步氛围，以促进可持续的联盟开展充满活力的研究项目，致力于减少撒哈拉以南非洲地区的癌症。