Admin Core

管理核心

• 批准号: 10598770
• 负责人: Charles Wood
• 金额: $ 28.51万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598770
• 关键词: AIDS related cancer; Address; Africa; Africa South of the Sahara; African; Biological Markers; Cancer Center; Caring; Chronic Disease; Climate; Clinical; Collaborations; Communication; Complex; Country; Detection; Development; Diagnosis; Diagnostic; Disease; Ensure; Environment; Goals; Group Meetings; HIV; HIV-1; Health Sciences; Hospitals; Human Herpesvirus 8; Immune response; Immunologics; Immunosuppression; Individual; Information Dissemination; Infrastructure; Institution; International; Kaposi Sarcoma; Leadership; Location; Louisiana; Malignant Neoplasms; Mission; Oceans; Outcome; Outcomes Research; Pathogenesis; Persons; Pilot Projects; Policies; Prevention; Process; Research; Research Activity; Research Infrastructure; Research Project Grants; Resource Sharing; Resources; Series; Tanzania; Teaching Hospitals; Technology; Tissues; Training; United States; United States National Institutes of Health; Universities; Viral; Viral reservoir; Virus Latency; Work; Zambia; anticancer research; antiretroviral therapy; career development; data dissemination; data integration; data management; data sharing; design; experience; improved; meetings; metabolomics; prevent; programs; success; synergism

A multi-institutional, international, and integrated endeavor, the “KS in the Era of ART in Africa Program (KEAAP)” will leverage the research and training expertise of collaborating institutions from the U.S. and two African countries: the Louisiana State University Health Sciences Center-New Orleans (LSUHSC-NO), the Cancer Diseases Hospital (CDH) and the University Teaching Hospitals (UTH) of Zambia, and the Ocean Road Cancer Institute (ORCI) in Dar es Salaam, Tanzania to form an HIV-Associated Malignancy Research Center (HAMRC) that focuses on the research gaps of the Kaposi sarcoma (KS) disease. Building on the success of their previous collaborations, these institutions will synergize their efforts under one overarching research theme that focuses on the KS disease spectrum, from detection, to care and outcomes, to deciphering KS pathogenesis and immune response. The immediate goal is to 1) implement a program to better integrate KS diagnostic, clinical and research activities within the HIV-1 care and treatment networks in both countries; 2) define stage- and treatment-associated immunologic and metabolomics biomarkers across the spectrum of KS disease presentation; and 3) define the magnitude and breadth of Kaposi sarcoma herpesvirus (KSHV) latent viral reservoirs in tissues of KSHV infected people living with HIV, so that these reservoirs could be targeted for prevention of viral reactivation to prevent KS. To achieve this goal and promote synergy and coordination across partnering institutions, KEAAP will establish an Administrative Core, based at LSUHSC-NO with satellite locations at UTH/CDH, and ORCI, that will provide the administrative support needed to ensure that KEAAP’s three research projects, Shared Resource Core (Data Management and Integration Core), and Career Development Core can accomplish their individual and collective goals while functioning in an integrated and coordinated manner. The Administrative Core will pursue four specific aims. 1) Provide the administrative expertise and resources necessary to support the consortium’s research projects and cores and the pilot projects to accomplish their goals and specific aims. 2) Implement a consortium-wide series of operational processes designed to create a collaborative research environment, promote data sharing and dissemination of results, and build capacity for increased self-sufficiency at cancer research institutions in Tanzania and Zambia. 3) Provide communications infrastructure to engage key stakeholders, to promote the consortium, and disseminate information and research outcomes that will inform healthy policy changes locally, and globally. The organization of the Administrative Core is designed to be responsive, inclusive, and robust – attributes that are essential to address the broad mission and complex relationships within KEAAP, among collaborating institutions, and with NIH. The core will focus on meeting the needs of the collaborators in a climate of rapidly changing scientific and technological advances in order to promote a sustainable consortium with vibrant research programs that work toward the reduction of cancer in sub-Saharan Africa.

多机构，国际和综合努力，“非洲艺术时代的KS” （KEAAP）”将利用来自美国和两个的合作机构的研究和培训专业知识 非洲国家：路易斯安那州立大学健康科学中心 - 新奥尔良（LSUHSC-NO）， 癌症疾病医院（CDH）和赞比亚的大学教学医院（UTH）和海洋 坦桑尼亚达累斯萨拉姆的公路癌研究所（ORCI）形成了与HIV相关的恶性研究 中心（HAMRC）着重于Kaposi肉瘤（KS）疾病的研究差距。建立在 他们以前合作的成功，这些机构将在一个总体下综合他们的努力 从检测到护理和结果，再到KS疾病范围的研究主题 破译KS发病机理和免疫反应。直接目标是1）实施一个程序 在HIV-1护理和治疗网络中，更好地整合KS诊断，临床和研究活动 两国; 2）定义跨阶段和治疗相关的免疫学和代谢组学生物标志物 KS疾病表现的范围； 3）定义Kaposi肉瘤的大小和广度 疱疹病毒（KSHV）在KSHV感染艾滋病毒的人的组织中潜在病毒储量，以便这些 可以将储层用于预防病毒重新激活以防止KS。实现这一目标并促进 KEAAP将在合作机构之间的协同作用和协调 LSUHSC-NO在UTH/CDH和ORCI的卫星位置，将提供行政支持 需要确保KEAAP的三个研究项目，共享资源核心（数据管理和 集成核心），职业发展核心可以实现其个人和集体目标，同时 以集成和协调的方式运作。行政核心将追求四个具体目标。 1）提供支持财团研究项目所需的行政专业知识和资源 还有核心和试点项目，以实现其目标和特定目标。 2）实施整个财团 一系列旨在创建协作研究环境，促进数据共享的运营过程 并传播结果，并在癌症研究机构中提高自给自足的能力 坦桑尼亚和赞比亚。 3）提供通信基础设施以吸引关键利益相关者，以促进 财团，并传播将在当地为健康政策变化提供信息的信息和研究成果 和全球。行政核心的组织旨在响应迅速，包容和健壮 - 解决KEAAP内部的广泛使命和复杂关系至关重要的属性 协作机构，并与NIH合作。核心将着重于满足合作者的需求 迅速变化的科学和技术进步的气候，以促进可持续财团 借助充满活力的研究计划，致力于减少撒哈拉以南非洲的癌症。