Cancer Control

癌症控制

基本信息

批准号：
10589911
负责人：
Matthew J Carpenter
金额：
$ 5.06万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10589911
关键词：
Academy Address Advanced Glycosylation End Products African American African American population Area Award Basic Science Behavioral Behavioral Sciences Biological Breast Cancer Patient Cancer Burden Cancer Center Cancer Center Support Grant Cancer Control Cancer Control Research Program Cancer Etiology Cancer Patient Caring Cervical Clinical Clinical Trials Collaborations Communities Complex Data Development Diagnostic Discipline of Nursing Dissemination and Implementation Doctor of Philosophy Enrollment Evaluation Evidence based intervention Exclusion Faculty Faculty Recruitment Fostering Funding Future Genetic Genets Goals Grant Head and Neck Cancer Health Health Policy Healthcare Systems Historically Black Colleges and Universities Human Papilloma Virus Vaccination Human Papilloma Virus Vaccine Incidence Individual Inpatients International Intervention Intervention Studies Intervention Trial Investments Journals K-Series Research Career Programs Lead Leadership Malignant Neoplasms Malignant neoplasm of ovary Malignant neoplasm of prostate Medical Medicine Mentors Minority Men Mission Molecular Molecular Epidemiology Morbidity - disease rate National Institute on Minority Health and Health Disparities Neurocognitive Outcome Outcomes Research Peer Review Physicians Population Research Population Sciences Predisposing Factor Predisposition Prevention Prevention strategy Psychiatry Psychological Factors Public Health Public Policy Publications Publishing Research Research Personnel Resource Sharing Risk Factors Scientist Services Shapes Smoking Source South Carolina Strategic Planning Supportive care System Time Tobacco Use Cessation Training Translating Translational Research United States National Institutes of Health Universities Work addiction base cancer health disparity care delivery career development clinical risk college community based practice cost effective epidemiology study evidence base genetic risk factor health disparity hospital readmission improved improved outcome innovation insight inter-institutional low socioeconomic status male health medicine man member minority health minority health disparity minority patient mortality nicotine vapor novel pharmacologic phase II trial population health precision medicine programs psychologic public policy on tobacco randomized, controlled study recruit relapse risk smoking addiction smoking cessation smoking relapse social social epidemiology social factors survivorship tobacco control vaccine acceptance

项目摘要

CANCER CONTROL PROGRAM: SUMMARY The Cancer Control (CC) Program fosters population sciences research that seeks to reduce cancer morbidity and mortality in South Carolina while providing novel, evidence-based cancer control interventions that can be applied beyond the state’s borders. Guided by two cross-cutting themes, cancer disparities and tobacco control, CC members have made marked progress in all areas. To address cancer health disparities, CC members es- tablished a precision medicine center to dissect and address the complex genetic, psychological, and social fac- tors impacting cancer disparities, established systems to increase the accrual of minority patients to clinical trials, and identified advanced glycation endproducts as a pharmacological target for a phase 2 trial in African Ameri- can cancer patients of low socioeconomic status. Advances in tobacco control include identification of neu- rocognitive mechanisms that increase smoking relapse risk, development of pharmacological strategies for smoking cessation, and implementation of an inpatient stop smoking service that reduces hospital readmissions. Co-led by Chanita Hughes-Halbert, PhD and Matthew J. Carpenter, PhD, national leaders in minority health and cancer disparities and tobacco control, respectively, the program comprises 25 population health and phy- sician-scientist faculty members from nine departments. Excluding career development and training grants, the annual total direct peer-reviewed funding base for the program is $4.4M, an increase of 37.5% since the prior renewal, with $1.6M from the NCI, $2.1M from other NIH awards, and $0.6M from other peer-reviewed sources. CC members foster collaborative research and lead several new large center awards and cooperative grants, including an NCI P01, NCI UG1, NCI U54, and an NIMHD U54. Through well-established training pipe- lines, members invest in mentoring and, as a result, six junior faculty hold peer-reviewed career development awards. During the past five years, CC members authored 183 cancer-relevant publications, of which 83% were collaborative with Hollings Cancer Center members in CC and other research programs. The exceptional quality of the program’s research is reflected by transformative insights into the causes of cancer disparities, discovery of molecular and behavioral risk factors underlying cancer susceptibility, and evaluation of evidence- based approaches to encourage tobacco cessation. These have been published in top-tier journals such as Lancet, Lancet Oncol, N Engl J Med, J Med Genet, Am J Respir and Crit Care Med, JAMA Psychiatry, J Clin Oncol, and Nat Genet. CC members launched innovative trial interventions in the areas of care delivery, pre- vention, supportive care, improved diagnostics, and survivorship, with 842 individuals enrolled in interventional studies in 2017. With continued strong faculty recruitment, mentoring of emerging independent scientists, and development of transdisciplinary team-based interprogrammatic initiatives, the CC Program is exceptionally well equipped to lead efforts in reducing the cancer burden in South Carolina.

癌症控制计划：摘要癌症控制（CC）计划促进了旨在减少癌症发病率的人群科学研究南卡罗来纳州的死亡率以及提供新颖的，循证的癌症控制干预措施超越州边界。在两个横切主题，癌症分布和烟草控制的指导下， CC成员在所有领域都取得了明显的进展。为了解决癌症健康分布，CC成员ES- 提出了一个精确的医学中心，以剖析和解决复杂的遗传，心理和社会方面影响癌症差异的TOR，建立的系统以提高少数族裔患者对临床试验的准确性，并确定高级糖基化最终产物是非洲ameri-的2期试验的药物靶标社会经济状况低下的癌症患者。烟草控制的进展包括识别neu- 增加吸烟救济风险的Rocognity机制，制定药物的策略戒烟，并实施住院的停止吸烟服务，以减少医院的再入院。由Chanita Hughes-Halbert博士和Matthew J. Carpenter博士共同领导，少数民族健康领导人该计划分别包括25种人口健康和PHY- 来自九个部门的西西亚语科学家教师。不包括职业发展和培训补助金，该计划的年度直接直接同行评审基础为440万美元，自之前的增长37.5％续签，来自NCI的160万美元，来自其他NIH奖的210万美元，其他同行评审的60万美元来源。 CC成员培养合作研究，并领导几个新的大型中心奖与合作赠款，包括NCI P01，NCI UG1，NCI U54和NIMHD U54。通过公认的训练管 - 台词，成员投资于心理，结果，六个初级教师持有同行评审职业发展奖项。在过去的五年中，CC成员撰写了183个与癌症相关的出版物，其中83％与CC和其他研究计划中的Hollings癌症中心成员合作。异常该计划研究的质量反映了对癌症分布原因的变革性见解，发现癌症易感性的分子和行为危险因素的发现，并评估证据 - 基于鼓励烟草戒烟的方法。这些已发表在顶级期刊上，例如柳叶刀，柳叶刀Oncol，N Engl J Med，J Med Genet，AM J呼吸和Crit Care Med，Jama Psychiatry，J Clin Oncol和Nat Genet。 CC成员在护理提供领域启动了创新的试验干预措施，发表，支持护理，改善诊断和生存，有842个人参加介入 2017年的研究。随着持续强大的教职招聘，新兴独立科学家的心理和开发基于跨学科团队的解释性倡议，CC计划是异常的能够在减少南卡罗来纳州的癌症伯恩（Cancer Burnen）方面进行努力。