Synergistic degradation of the bonded interface: A new approach to evaluate the bond strength of dental restoration

粘合界面的协同降解：评估牙科修复体粘合强度的新方法

基本信息

批准号：
10589775
负责人：
Mary Anne Sampaio de Melo
金额：
$ 15.78万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-11 至 2024-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10589775
关键词：
16S ribosomal RNA sequencing Acids Adhesives Anti-Bacterial Agents Bacteria Biocompatible Materials Biodegradation Biological Biological Models Chemicals Clinical Clinical Data Clinical Services Composite Resins Dental Dental General Practice Dental Materials Dental caries Dentin Development Economic Burden Environment Enzymes Exposure to Failure Fatigue Formulation Future Goals Human In Vitro Individual Infiltration Laboratories Mastication Mechanics Methods Microbial Biofilms Microscopy Mouth Diseases Oral health Outcome Performance Periodicity Plant Resins Policies Prevention Procedures Publishing Reproducibility Research Saliva Salivary Sampling Source Streptococcus mutans Sucrose Techniques Testing Tissues Tooth Loss Tooth structure Visual Work clinical predictors clinical translation clinically relevant combinatorial composite restoration cost dental adhesive dental resin dysbiosis healing improved in vivo innovation mechanical load microCT microbial microbiome novel strategies oral condition oral microbial community pathogenic bacteria pre-clinical predictive modeling premature remineralization restoration restorative dentistry restorative treatment synergism trigger point

项目摘要

PROJECT SUMMARY After nearly seven decades of research, dental composites restorations continue to show limited clinical service, with more than 50% of placed bonded restorations failing in less than ten years. Pathogenic bacteria and human salivary enzymes produce detrimental products that degrade dental resins and adhesives. As a result, the bond strength is debilitated, which increases the progression of secondary caries, premature failure of restoration, and tooth loss. Current approaches to evaluate the effects of biodegradation sources on bond strength are failing to replicate clinical conditions in a laboratory setting. Our goal is to develop an experimental approach for accurately predicting composite restorations' lifetime using realistic environments. Our innovative approach significantly improves existing methods by challenging bonded interfaces to different degradative sources simultaneously. In this study, we proposed to find the specific contribution of the main degradative sources (salivary enzymes, bacteria enzymes and acids, and cyclic mechanical loading) after working in synergy on bond strength reduction (aim 1). We will also evaluate the bond strength durability of dentin/resin composites interfaces within a clinically relevant microbiome environment. This project will assess the degradation of the tooth-restoration interface under representative oral conditions and will help elucidate the individual and synergistic effects of the primary degradative sources on bond strength durability. The application of this novel approach will help improve the prediction of the durability of composite restorations, thereby rendering the restorative treatment more predictable

项目摘要经过将近七十年的研究，牙科复合材料修复体继续显示有限的临床服务，超过50％的债券修复体在不到十年的时间内就失败了。致病细菌人类唾液酶产生有害的产物，降解牙科树脂和粘合剂。作为结果，粘结强度会衰弱，这增加了次龋齿的进展，过早失败修复和牙齿脱落。当前评估生物降解源对键影响的方法在实验室环境中，力量无法复制临床状况。我们的目标是开发实验方法，用于使用现实环境准确预测复合修复体的寿命。我们的创新方法通过挑战键合的界面来大大改善现有方法同时降解来源。在这项研究中，我们提议找到主要的特定贡献降解源（唾液酶，细菌和酸，以及环状机械载荷）之后在协同作用方面降低粘结强度（AIM 1）。我们还将评估债券强度的耐久性牙本质/树脂复合材料在临床相关的微生物组环境中界面。这个项目将评估在代表性口服条件下牙齿恢复界面的降解，并将有助于阐明主要降解源对键强度耐用性的个体和协同作用。这种新颖方法的应用将有助于提高复合耐用性的预测修复物，从而使恢复性处理更可预测