Multi-scale, multi-organ, multi-species SPARC map management

多尺度、多器官、多物种SPARC图谱管理

• 批准号: 10591843
• 负责人: Peter John Hunter
• 金额: $ 4.2万
• 依托单位: UNIVERSITY OF AUCKLAND
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-23 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10591843
• 关键词: Maps; Text

Summary/Abstract for NIH-SPARC MAP-CORE The aim of this project is to provide tools for visualising data and models generated by the SPARC (Stimulating Peripheral Activity to Relieve Conditions) consortium, which is generating data and models associated with the autonomic nervous system. By mapping the paths of these nerves throughout the body and understanding their role in controlling organ function, the NIH funded program will help provide the means for medical device companies to develop new stimulators that can modulate organ function in order to improve physiological function and hence relieve a medical condition. The MAP-CORE is one of three components of the Data and Resource Centre (DRC) for SPARC. DAT- CORE will manage the actual data generated by the SPARC community. MAP-CORE will integrate the multiple types of data (also from multiple species) into a cohesive whole, and organise and display it in a way that is useful to both the SPARC science community and the medical device companies. SIM-CORE will develop a framework, including simulation tools, to connect mathematical models of neural and other physiological activity based on the SPARC data. The MAP-CORE will ensure that suitable community standards such as CellML, SBML, FieldML and SED-ML are used (and if necessary, further developed) for encoding and annotating the data, models and simulations to ensure reproducibility, and to help ensure that all data and models are appropriately annotated to make them findable and accessible by the community in the DAT-CORE database. MAP-CORE will use ApiNATOMY to provide annotations for biological context and a framework for implementing biophysical concepts such as conservation of mass and conservation of energy. A portal, based on web 2.0 and subsequent standards, will be developed that brings the anatomy and multiscale physiology of all organ systems into a single database-driven user interface. The user will be able to examine data and models at all scales and to generate predictive multiscale models (solved with the SIM-CORE tools) to answer specific questions associated with the autonomic control of the visceral organs.

NIH-SPARC地图核的摘要/摘要 该项目的目的是提供用于可视化数据和模型的工具，由SPARC（刺激外围活动以缓解条件）联盟，该联盟正在生成与自主神经系统相关的数据和模型。通过绘制这些神经在整个身体中的路径并了解它们在控制器官功能中的作用，NIH资助的计划将有助于医疗设备公司开发可以调节器官功能以改善生理功能并因此缓解医疗状况的新刺激器的手段。 地图核是SPARC数据和资源中心（DRC）的三个组件之一。 Dat-Core将管理SPARC社区生成的实际数据。地图核心将将多种类型的数据（也从多种物种）整合到一个凝聚力整体中，并以对SPARC科学界和医疗设备公司都有用的方式组织和显示。 SIM核将开发一个框架，包括仿真工具，以基于SPARC数据连接神经和其他生理活动的数学模型。 地图核将确保使用（如有必要的话）（以及在必要时，进一步开发）诸如CellML，SBML，FieldML和SED-ML之类的合适社区标准来编码和注释数据，模型和模拟，以确保可重复可重复性，并帮助确保所有数据和模型都适当地注释，以使其可在数据级数据持续数据库中找到和访问。地图核心将使用Apinatome为生物学环境提供注释，并为实施生物物理概念（例如保护质量和能源保存）等生物物理概念提供注释。将开发基于Web 2.0及后续标准的门户网站，该门户将将所有器官系统的解剖结构和多尺度生理学带入单个数据库驱动的用户界面。用户将能够在各个尺度上检查数据和模型，并生成预测性的多尺度模型（使用SIM核工具解决），以回答与内脏器官的自主控制相关的特定问题。