LA-Aging Diversity Supplement

洛杉矶-老龄化多样性补充

• 批准号: 10592204
• 负责人: MARK Andrew ESPELAND
• 金额: $ 0.3万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592204
• 关键词: Aging; Biological Aging; Buffers; Cardiovascular Diseases; Cardiovascular system; Clinical Trials; Control Groups; Data Analyses; Development; Diabetes Mellitus; Doctor of Philosophy; Elderly; Event; Funding; Goals; Health; Incidence; Individual; Intervention; Link; Measures; Mentors; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome Measure; Participant; Physical Function; Prevalence; Principal Investigator; Process; Publishing; Research; Research Personnel; Research Support; Role; Series; Syndrome; Talents; Time; Universities; cognitive function; cohort; data resource; experience; follow-up; frailty; indexing; lifestyle intervention; mortality risk; parent grant; preservation; programs; tool; undergraduate student

Project Summary/Abstract OVERALL – PROJECT SUMMARY Obesity and type 2 diabetes are described as accelerators aging. There have been numerous attempts across decades to develop and validate measureable constructs for accelerated aging. We have conducted research supported by two prior successful NIDDK-funded diversity supplements to develop and apply deficit accumulation frailty indices to the first 8 years of follow-up in the Look AHEAD cohort, the span of time when all participants were assigned to active interventions. This has been a productive enterprise. We have published that:  The Look AHEAD intensive lifestyle intervention (ILI) created a buffer against increases in FI, roughly proportional to one year of aging in the control group  Among participants with relatively low FI at baseline, the ILI resulted in lower incidence of major cardiovascular disease events, however among participants with the highest FI scores at baseline, the ILI was associated with an increased incidence of cardiovascular events  The Look AHEAD ILI was equally ineffectual in preserving cognitive function across the full range of baseline FI  Greater increases in FI across 8 years was associated with subsequent increased risk for mortality and poorer trajectories of physical and cognitive function We propose to conduct a series of secondary data analyses, using the extensive data resources provided by the Look AHEAD cohort, 1) to extend the deficit accumulation FI originally developed by Look AHEAD through year 8 to the close-out of the Look AHEAD Extension (Year 18), producing FIE; 2) to develop a statistical bridge linking this FI with one being developed by the parent grant (LA-Aging) for years 19-23 of follow-up (FIA); and 3) to examine how trajectories of FIE are related to the prevalence of geriatric syndromes in the Look AHEAD Aging study. If successful, this project will provide a validated marker of long-term biological aging that can serve as an outcome measure in clinical trials and a tool for identifying factors that slow aging among older adults with type 2 diabetes and obesity. A complementary goal of this project is to further the development of Johnathan Ross, a promising undergraduate student at Winston-Salem State University, a historically black public research university. His primary mentor will be Dr. Mark Espeland, who is experienced and well-suited for this role. We respond to PA- 21-071 Research Supplements to Promote Diversity in Health-Related Research. Summary of Planned Contributions to the Look AHEAD Program. This request is attached to 1U01AG073697-01: Action for Health in Diabetes (Look AHEAD) Extended Follow-up (LA-Aging) Mark A. Espeland, PhD, Dual Principal Investigator.

项目摘要/摘要 总体 - 项目摘要 肥胖症和2型糖尿病被描述为加速器衰老。 数十年来开发和验证可加速的衰老构建体。 得到了两个先前成功的NIDDK资助的多样性补充，以开发和应用默认 在前面的前景中的前8年，累积累积的差异是 所有参与者都被分配给了我们拥有的生产企业 发表： 未来的外观密集的生活方式干预（ILI）创造了一种缓冲，以防止FI增加，大致 与受控小组的衰老一年成正比 在基线时相对较低的FI参与者中，ILI导致主要发病率较低 但是，在基线时FI得分最高的参与者中，心血管疾病事件，ILI 与心血管事件的增加有关 在保留认知功能的全部范围 基线FI 在8年中，FI的增加增加了与随后增加的荒谬风险相关的危险和 身体和认知功能较差的轨迹 我们建议使用由级别的数据资源来转换一系列辅助数据分析 前面的外观，1）扩大了最初通过向前看而开发的赤字积累fi 第8年的近距离外观延长（第18年），生产FIE； 将此FI与父母赠款（LA-Agging）开发的桥梁已有19 - 23年的随访 （FIA）和3）检查FIE的轨迹与老年综合征的患病率有关 在衰老研究之前。 可以用作临床试验的结果指标，并成为识别老年人老化的因素 患有2型糖尿病和肥胖症的成年人。 该项目的一个编译目标是进一步发展约翰森·罗斯（Johnathan Ross），这是一个有前途的 他的地下学生在历史上是黑人公共研究 主要的导师将是Mark Espeland博士，他对这个角色非常适合。 21-071研究旨在促进与健康相关研究的多样性。 对外观的贡献。 在糖尿病中（前面）扩展后续行动（LA-AGGIG）标记A。 研究者。