LA-Aging Diversity Supplement

洛杉矶-老龄化多样性补充

• 批准号: 10592204
• 负责人: MARK Andrew ESPELAND
• 金额: $ 0.3万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592204
• 关键词: Aging; Biological Aging; Buffers; Cardiovascular Diseases; Cardiovascular system; Clinical Trials; Control Groups; Data Analyses; Development; Diabetes Mellitus; Doctor of Philosophy; Elderly; Event; Funding; Goals; Health; Incidence; Individual; Intervention; Link; Measures; Mentors; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome Measure; Participant; Physical Function; Prevalence; Principal Investigator; Process; Publishing; Research; Research Personnel; Research Support; Role; Series; Syndrome; Talents; Time; Universities; cognitive function; cohort; data resource; experience; follow-up; frailty; indexing; lifestyle intervention; mortality risk; parent grant; preservation; programs; tool; undergraduate student

Project Summary/Abstract OVERALL – PROJECT SUMMARY Obesity and type 2 diabetes are described as accelerators aging. There have been numerous attempts across decades to develop and validate measureable constructs for accelerated aging. We have conducted research supported by two prior successful NIDDK-funded diversity supplements to develop and apply deficit accumulation frailty indices to the first 8 years of follow-up in the Look AHEAD cohort, the span of time when all participants were assigned to active interventions. This has been a productive enterprise. We have published that:  The Look AHEAD intensive lifestyle intervention (ILI) created a buffer against increases in FI, roughly proportional to one year of aging in the control group  Among participants with relatively low FI at baseline, the ILI resulted in lower incidence of major cardiovascular disease events, however among participants with the highest FI scores at baseline, the ILI was associated with an increased incidence of cardiovascular events  The Look AHEAD ILI was equally ineffectual in preserving cognitive function across the full range of baseline FI  Greater increases in FI across 8 years was associated with subsequent increased risk for mortality and poorer trajectories of physical and cognitive function We propose to conduct a series of secondary data analyses, using the extensive data resources provided by the Look AHEAD cohort, 1) to extend the deficit accumulation FI originally developed by Look AHEAD through year 8 to the close-out of the Look AHEAD Extension (Year 18), producing FIE; 2) to develop a statistical bridge linking this FI with one being developed by the parent grant (LA-Aging) for years 19-23 of follow-up (FIA); and 3) to examine how trajectories of FIE are related to the prevalence of geriatric syndromes in the Look AHEAD Aging study. If successful, this project will provide a validated marker of long-term biological aging that can serve as an outcome measure in clinical trials and a tool for identifying factors that slow aging among older adults with type 2 diabetes and obesity. A complementary goal of this project is to further the development of Johnathan Ross, a promising undergraduate student at Winston-Salem State University, a historically black public research university. His primary mentor will be Dr. Mark Espeland, who is experienced and well-suited for this role. We respond to PA- 21-071 Research Supplements to Promote Diversity in Health-Related Research. Summary of Planned Contributions to the Look AHEAD Program. This request is attached to 1U01AG073697-01: Action for Health in Diabetes (Look AHEAD) Extended Follow-up (LA-Aging) Mark A. Espeland, PhD, Dual Principal Investigator.

项目摘要/摘要 总体 - 项目摘要 肥胖和2型糖尿病被描述为加速器衰老。有很多尝试 开发和验证可测量构造的数十年来加速衰老。我们进行了研究 得到了两个先前成功的NIDDK资助的多样性补充，以开发和应用国防 累积脆弱的指数到后期8年的前8年，即前景， 所有参与者都被分配给主动干预措施。这是一家富有成效的企业。我们有 发表： 未来的外观密集的生活方式干预（ILI）创造了一种缓冲，以防止FI增加，大致 与对照组的衰老一年成比例 在基线时FI相对较低的参与者中，ILI导致主要事件的较低事件 但是，在基线时FI得分最高的参与者中，心血管疾病事件，ILI 与心血管事件的增加有关 iLi的外观在整个范围内保持认知功能方面同样无效 基线FI 在8年中，FI的增加增加与随后的死亡风险增加有关 身体和认知功能较差的轨迹 我们建议使用提供的广泛数据资源进行一系列二级数据分析 前面的外观，1）扩大了最初通过浏览而开发的不足的积累FI 八年级即将展开未来的外观延长（第18年），生产Fie； 2）开发统计数据 将此FI与父母赠款（LA-AVEND）开发的桥梁连接了19 - 23年的随访 （FIA）; 3）检查FIE的轨迹与外观中老年综合症的流行有关 衰老研究。如果成功，该项目将提供有效的长期生物学衰老的标记 可以作为临床试验的结果指标，也可以作为识别较慢衰老的因素的工具 患有2型糖尿病和肥胖症的成年人。 该项目的一个完整目标是进一步发展约翰森·罗斯（Johnathan Ross），这是一个承诺 温斯顿·塞勒姆州立大学的本科生，历史悠久的黑人公共研究大学。他的 主要导师将是Mark Espeland博士，他经验丰富且非常适合这个角色。我们回应PA- 21-071的研究补充剂旨在促进与健康相关研究的多样性。计划的摘要 对展望未来计划的贡献。此请求附加到1U01AG073697-01：健康行动 在糖尿病（前面）延长后续（LA-AVED）Mark A. Espeland，博士学位，双校长 研究者。