ZFIN: The Zebrafish Model Organism Database

ZFIN：斑马鱼模式生物数据库

• 批准号: 10614979
• 负责人: Monte Westerfield
• 金额: $ 200.99万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-11 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10614979
• 关键词: Adopted; Affect; Antisense Oligonucleotides; Articulation; Base Sequence; Behavior; Biological; Biomedical Research; Code; Communities; Computer software; Data; Data Science; Data Set; Databases; Development; Disease; Elements; Evolution; FAIR principles; Gene Expression; Generations; Genes; Genetic; Genetic Models; Genome; Genomics; Goals; Guidelines; Human; Human Biology; Human Genome; Individual; Industry Standard; Information Networks; Infrastructure; International; Laboratories; Link; Metadata; Modeling; Mutate; Mutation; Nomenclature; Organism; Organogenesis; Orthologous Gene; Other Genetics; Pattern; Phenotype; Physiological; Physiology; Play; Process; Proteins; Publications; Readability; Recovery; Research; Research Activity; Research Personnel; Resources; Role; Site; Societies; Software Tools; Strategic Planning; Structure; Surveys; Techniques; Technology; Time; Training; Transgenic Organisms; United States National Institutes of Health; Update; Vertebrate Biology; Vertebrates; Visualization; Work; Zebrafish; data access; data curation; data exchange; data management; data resource; gene conservation; gene function; genetic analysis; genome analysis; genome editing; genome resource; human disease; human model; improved; insight; knock-down; knockout gene; meetings; model organism; model organisms databases; outreach; public database; reference genome; repository; software systems; symposium; tool; user centered design; web site; wiki

Discovering the functions of the tens of thousands of genes in the human genome is a required step for understanding human biology and disease. Genetic model organisms, including zebrafish, play a critical role in this discovery process, because genetic analysis can connect gene sequence and function. Model organism databases, like ZFIN, provide tools required to make this connection. The zebrafish has emerged as a premier organism to study vertebrate biology. Powerful techniques allow rapid efficient generation and recovery of mutations affecting genes that orchestrate developmental patterning, organogenesis, physiology, and behavior. It is easy to study gene function by generating transgenic zebrafish, by knocking down gene function with morpholino antisense oligonucleotides, or by altering gene function by genome editing. The genome has been sequenced and about 50% of the protein coding genes have been mutated by targeted gene knockout technology. Large-scale projects are underway or planned that will produce functional data about almost all the genes and sequence-based functional elements in the genome. Multiple mutations and gene knockdowns can be combined in the same individual to study gene modifiers and other genetic interactions. The functions of most of these genes are conserved among vertebrate groups. Thus, analysis of zebrafish mutations provides insights into gene functions in other vertebrates, including humans. The long term goals for ZFIN are a) to be the community database resource for the laboratory use of zebrafish, b) to develop and support integrated zebrafish genetic, genomic, developmental, and physiological information, c) to maintain the definitive reference data sets of zebrafish research information, d) to link this information extensively to corresponding data in other model organism and human databases, e) to facilitate the use of zebrafish as a model for human biology, and f) to help serve the broad needs of the biomedical research community. This project will continue and expand curation of zebrafish research data, develop expanded support for zebrafish models of human disease, expand and integrate links to other databases, and maintain and update the zebrafish reference genome. This work will provide a powerful means for researchers to associate gene sequence and function, thus facilitating studies of human gene function and disease as well as cross-species analyses of genome organization and evolution.

发现人类基因组中成千上万基因的功能是必需的步骤 了解人类的生物学和疾病。遗传模型生物，包括斑马鱼，在 这种发现过程，因为遗传分析可以连接基因序列和功能。模型生物 像ZFIN一样，数据库提供了建立此连接所需的工具。 斑马鱼已经成为研究脊椎动物生物学的主要生物体。强大的技术允许 快速有效地产生和恢复影响策划发展模式的基因的突变， 器官发生，生理和行为。通过产生转基因斑马鱼，研究基因功能很容易研究， 通过用吗啡反义寡核苷酸敲低基因功能，或通过改变基因功能 基因组编辑。基因组已经测序，约有50％的蛋白质编码基因已经 被靶向基因敲除技术突变。大规模项目正在进行或计划 关于基因组中几乎所有基因和基于序列的功能元件的功能数据。 多个突变和基因敲低可以在同一个体中合并，以研究基因修饰剂和 其他遗传相互作用。这些基因中大多数的功能在脊椎动物组之间是保守的。 因此，斑马鱼突变的分析提供了对其他脊椎动物中基因功能的见解，包括 人类。 Zfin的长期目标是a）成为实验室使用的社区数据库资源 斑马鱼，b）开发和支持综合的斑马鱼遗传，基因组，发育和生理 信息，c）维护斑马鱼研究信息的确定参考数据集，d）链接此信息 信息广泛地涉及其他模型生物体和人类数据库中的相应数据，e）促进 斑马鱼用作人类生物学的模型，f）帮助满足生物医学的广泛需求 研究社区。 该项目将继续并扩大斑马鱼研究数据的策划，并为 斑马鱼的人类疾病模型，扩展和整合到其他数据库的链接，并维护和更新 斑马鱼参考基因组。这项工作将为研究人员与基因关联提供有力的手段 序列和功能，从而促进人类基因功能和疾病以及跨物种的研究 基因组组织和进化的分析。