Aflatoxin exposure and hepatocellular carcinoma in Mexico

墨西哥的黄曲霉毒素暴露与肝细胞癌

基本信息

批准号：
10614766
负责人：
Martin Lajous
金额：
$ 8.91万
依托单位：
MEXICO NATIONAL INSTITUTE OF PUBLIC HLTH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10614766
关键词：
Address Affect Aflatoxin B1 Aflatoxins Africa South of the Sahara Albumins Alcohols Americas Area Automobile Driving Biological Markers Blood Cancer Burden Cancer Etiology Cancer Research Network Central America Cessation of life Characteristics Clinical Collaborations Communities Country Data Diabetes Mellitus Environment Environmental Health Environmental Pollution Epidemiology Etiology Evaluation Exons Exposure to Face Far East Female Food Fostering Future Gene Mutation Geography Guatemala HBV and Aflatoxin Health Surveys Hepatitis B Prevalence Hepatitis B Virus Hepatitis C virus High Prevalence Hispanic Populations Hospitals Immigrant Incidence Induced Mutation Infection Institution International Liver Low Prevalence Maize Measures Metabolic syndrome Mexican Americans Mexico Missense Mutation Mutation Needs Assessment Nutrition Surveys Obesity Pattern Population Primary carcinoma of the liver cells Public Health Records Research Research Activity Research Infrastructure Research Personnel Resources Risk Risk Factors Rural Rural Population Sampling Scientist Seroprevalences Serum Surveys TP53 gene Tumor Tissue Variant Woman Work adduct anticancer research base biobank burden of illness cancer epidemiology cancer prevention dietary environment related cancer insight male men mortality prospective public health relevance rural area

项目摘要

Project Summary Aflatoxin B1 (AFB1) is a fungal contaminant in food that may be exerting a significant impact on the increasing hepatocellular cancer (HCC) burden in Mexico. HCC epidemiology in Mexico is unusual given the low prevalence of hepatitis virus B and C infection, similar HCC mortality among men and women, and a rural- urban gradient. In Mexico, maize, a staple food, appears to be commonly contaminated by aflatoxins. Thus, AFB1 contamination alone or in combination with non-viral risk factors may be driving HCC incidence rates. We aim to provide initial data on the relevance of AFB1 for HCC in Mexico, while strengthening research capacity for future needs. We specifically will (1) measure circulating AFB1 from 955 women and men from four high HCC burden areas; and (2) create a research network to retrospectively identify aflatoxin-induced mutations in liver samples and determine the feasibility of prospectively obtaining clinical information and biospecimens from incident HCC cases. We will gain insight into HCC risk factors in a population with a unique epidemiological pattern, demonstrate our capacity to access an existing biorepository that will become an important resource for future environmental and cancer research, and create a strong research environment that will foster future collaborative efforts with local, regional, and international scientists.

项目概要黄曲霉毒素 B1 (AFB1) 是食品中的一种真菌污染物，可能对日益增长的细菌产生重大影响。墨西哥的肝细胞癌（HCC）负担。鉴于墨西哥的 HCC 发病率较低，其流行病学情况不同寻常乙型和丙型肝炎病毒感染的患病率、男性和女性中类似的 HCC 死亡率以及农村地区的城市梯度。在墨西哥，作为主食的玉米似乎普遍受到黄曲霉毒素的污染。因此， AFB1 污染单独或与非病毒危险因素结合可能会增加 HCC 发病率。我们的目标是提供有关 AFB1 与墨西哥 HCC 相关性的初步数据，同时加强研究未来需求的能力。我们特别将 (1) 测量来自 955 名女性和男性的循环 AFB1 四个 HCC 高负担区域； (2) 创建一个研究网络来回顾性地识别黄曲霉毒素引起的肝脏样本中的突变并确定前瞻性获取临床信息的可行性来自 HCC 病例的生物样本。我们将深入了解具有独特特征的人群中的 HCC 风险因素流行病学模式，展示我们访问现有生物储存库的能力，该生物储存库将成为未来环境和癌症研究的重要资源，创造强大的研究环境这将促进未来与当地、区域和国际科学家的合作。