Aflatoxin exposure and hepatocellular carcinoma in Mexico

墨西哥的黄曲霉毒素暴露与肝细胞癌

基本信息

批准号：
10614766
负责人：
Martin Lajous
金额：
$ 8.91万
依托单位：
MEXICO NATIONAL INSTITUTE OF PUBLIC HLTH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10614766
关键词：
Address Affect Aflatoxin B1 Aflatoxins Africa South of the Sahara Albumins Alcohols Americas Area Automobile Driving Biological Markers Blood Cancer Burden Cancer Etiology Cancer Research Network Central America Cessation of life Characteristics Clinical Collaborations Communities Country Data Diabetes Mellitus Environment Environmental Health Environmental Pollution Epidemiology Etiology Evaluation Exons Exposure to Face Far East Female Food Fostering Future Gene Mutation Geography Guatemala HBV and Aflatoxin Health Surveys Hepatitis B Prevalence Hepatitis B Virus Hepatitis C virus High Prevalence Hispanic Populations Hospitals Immigrant Incidence Induced Mutation Infection Institution International Liver Low Prevalence Maize Measures Metabolic syndrome Mexican Americans Mexico Missense Mutation Mutation Needs Assessment Nutrition Surveys Obesity Pattern Population Primary carcinoma of the liver cells Public Health Records Research Research Activity Research Infrastructure Research Personnel Resources Risk Risk Factors Rural Rural Population Sampling Scientist Seroprevalences Serum Surveys TP53 gene Tumor Tissue Variant Woman Work adduct anticancer research base biobank burden of illness cancer epidemiology cancer prevention dietary environment related cancer insight male men mortality prospective public health relevance rural area

项目摘要

Project Summary Aflatoxin B1 (AFB1) is a fungal contaminant in food that may be exerting a significant impact on the increasing hepatocellular cancer (HCC) burden in Mexico. HCC epidemiology in Mexico is unusual given the low prevalence of hepatitis virus B and C infection, similar HCC mortality among men and women, and a rural- urban gradient. In Mexico, maize, a staple food, appears to be commonly contaminated by aflatoxins. Thus, AFB1 contamination alone or in combination with non-viral risk factors may be driving HCC incidence rates. We aim to provide initial data on the relevance of AFB1 for HCC in Mexico, while strengthening research capacity for future needs. We specifically will (1) measure circulating AFB1 from 955 women and men from four high HCC burden areas; and (2) create a research network to retrospectively identify aflatoxin-induced mutations in liver samples and determine the feasibility of prospectively obtaining clinical information and biospecimens from incident HCC cases. We will gain insight into HCC risk factors in a population with a unique epidemiological pattern, demonstrate our capacity to access an existing biorepository that will become an important resource for future environmental and cancer research, and create a strong research environment that will foster future collaborative efforts with local, regional, and international scientists.

项目摘要黄曲霉毒素B1（AFB1）是食物中一种真菌污染物，可能对增加的增加影响墨西哥的肝癌（HCC）负担。鉴于低的HCC流行病学在墨西哥很不寻常肝炎病毒B和C感染的患病率，男性和女性的HCC死亡率相似，农村城市梯度。在墨西哥，玉米是一种主要食品，似乎通常被黄曲霉毒素污染。因此， AFB1单独污染或与非病毒危险因素结合使用可能会推动HCC发病率。我们旨在提供有关AFB1与HCC在墨西哥相关性的初始数据，同时加强研究未来需求的能力。我们专门将（1）测量从955名男女循环的AFB1 四个高HCC负担区域；（2）创建一个研究网络，以追溯识别黄曲霉毒素诱导的肝样品中的突变，并确定前瞻性获取临床信息的可行性和事件HCC病例的生物测量。我们将深入了解具有独特的人群中的HCC风险因素流行病学模式，证明了我们进入现有生物座席的能力，这将成为一种未来环境和癌症研究的重要资源，并创造了强大的研究环境这将促进与地方，地区和国际科学家的未来合作努力。