Longitudinal Study of HIV and Aging in Brazil

巴西艾滋病毒与老龄化的纵向研究

基本信息

批准号：
10613799
负责人：
Jessica L Castilho
金额：
$ 37.12万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10613799
关键词：
2019-nCoV Acute Adult Age Aging Blood Vessels Brazil CD4 Lymphocyte Count CD8-Positive T-Lymphocytes COVID-19 COVID-19 complications COVID-19 pandemic COVID-19 risk COVID-19 survivors COVID-19 susceptibility COVID-19 vaccination COVID-19 vaccine Cessation of life Clinical Clinical Data Cognition Cognitive Cognitive deficits Complication Cross-Sectional Studies Data Elderly Epidemiology Fatigue Frequencies Funding HIV Immune Immune response Immunologics Immunology Impaired cognition Incidence Income Individual Infection Inflammation Intervention Investigation Knowledge Lead Long COVID Longitudinal Studies Measures Mental Depression Neurocognitive Outcome Outcome Measure Participant Persons Phenotype Population Post-Acute Sequelae of SARS-CoV-2 Infection Quality of life Recording of previous events Risk Risk Factors SARS-CoV-2 antibody SARS-CoV-2 infection Standardization Symptoms Syndrome T-Lymphocyte Testing Time United States National Institutes of Health Vaccination Virus Diseases adverse outcome biobank cell age circulating biomarkers clinical phenotype cohort comorbidity coronavirus disease disability exhaustion experience frailty high risk human old age (65+)improved insight long-term sequelae low and middle-income countries low socioeconomic status meetings mortality neurocognitive test neuroinflammation neuropsychiatric symptom neuropsychiatry neutralizing antibody novel pandemic disease post SARS-CoV-2 infection post-COVID-19 senescence symptomatic COVID-19 systemic inflammatory response

项目摘要

PROJECT SUMMARY This study will investigate the epidemiology and immunology of neurocognitive symptoms of post-acute sequelae of COVID-19 (PASC, or “long COVID”) in older people living with HIV (PWH). Cognitive decline remains a common and important complication of aging with HIV and is associated with adverse outcomes including frailty, poor quality of life, disability, and death. Lasting neurocognitive symptoms of COVID-19 may be more common in older PWH given their risk factors for PASC as well as differences in underlying immune senescence and inflammation. However, the clinical burden and immunologic phenotypes of neurocognitive symptoms of PASC in older PWH have not been described to date. This information is particularly needed in low- and middle-income countries where heterologous SARS-CoV-2 vaccinations and high COVID-19 incidence were observed. This study will examine (1) the clinical phenotypes and determinants of neuropsychiatric outcomes measures among older PWH with PASC and will seek to determine (2) the immunologic and clinical profiles of older PWH with discordant immunologic and clinical sequelae of SARS- CoV-2 infection. A nested, cross-sectional study using the rich baseline clinical data and biospecimens of the NIA-funded Longitudinal Study of HIV and Aging in Brazil will collect detailed data of COVID-19 infections, symptoms, and prior vaccination to identify older PWH with PASC. A cohort of 300 participants with and without PASC will undergo additional neurocognitive testing to describe specific cognitive phenotypes in older PWH with and without PASC. Further, we will use stored biospecimens to identify older PWH with poor immunologic response to COVID-19 infection and vaccination as well as those with and without PASC to examine differences in adaptive immune senescence and systemic measures of neuroinflammation to identify clues of the immunologic mechanisms contributing to adverse COVID-19 outcomes in this population. Located in one of the epicenters of the COVID-19 pandemic and led by experts in HIV and COVID-19 epidemiology and immunology, this study will offer novel and needed insights into a critical complication of the COVID-19 pandemic in PWH.

项目摘要这项研究将研究急性后神经认知症状的流行病学和免疫学艾滋病毒（PWH）的老年人的covid-19（pasc或“长卷”）的后遗症。认知能力下降仍然是艾滋病毒衰老的常见且重要的并发症，并且与不良后果有关包括脆弱，生活质量差，残疾和死亡。 Covid-19的持久神经认知症状5月鉴于其PASC的危险因素以及潜在免疫的差异，在较旧的PWH中更为常见衰老和炎症。但是，神经认知的临床烧伤和免疫学表型迄今为止，尚未描述PASC的PASC症状。此信息特别需要低收入和中等收入国家，这些国家异源SARS-COV-2疫苗接种和高量COVID-19 观察到发生率。这项研究将检查（1）临床表型和决定剂 PASC较老的PWH中的神经精神结局措施，并将寻求（2）较老的PWH的免疫学和临床特征，具有不一致的免疫和临床后遗症。 COV-2感染。一项使用丰富的基线临床数据和生物测量的嵌套，横断面研究 NIA资助的巴西艾滋病毒和衰老的纵向研究将收集Covid-19感染的详细数据，症状和事先通过PASC识别较老的PWH的疫苗接种。与300名参与者组成的队列没有PASC 带有PASC的PWH。此外，我们将使用储存的生物测量来识别较差的PWH 对COVID-19的感染和疫苗接种以及有和没有PASC的免疫反应检查适应性免疫敏感和全身性神经炎症的差异，以鉴定免疫机制的线索导致该人群中不良的19性结果。位于在COVID-19大流行的中心之一，由HIV和Covid-19的专家领导免疫学，这项研究将提供新颖和需要的见解，以了解Covid-19的关键并发症 PWH中的大流行。