Longitudinal Study of HIV and Aging in Brazil

巴西艾滋病毒与老龄化的纵向研究

基本信息

批准号：
10613799
负责人：
Jessica L Castilho
金额：
$ 37.12万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10613799
关键词：
2019-nCoV Acute Adult Age Aging Blood Vessels Brazil CD4 Lymphocyte Count CD8-Positive T-Lymphocytes COVID-19 COVID-19 complications COVID-19 pandemic COVID-19 risk COVID-19 survivors COVID-19 susceptibility COVID-19 vaccination COVID-19 vaccine Cessation of life Clinical Clinical Data Cognition Cognitive Cognitive deficits Complication Cross-Sectional Studies Data Elderly Epidemiology Fatigue Frequencies Funding HIV Immune Immune response Immunologics Immunology Impaired cognition Incidence Income Individual Infection Inflammation Intervention Investigation Knowledge Lead Long COVID Longitudinal Studies Measures Mental Depression Neurocognitive Outcome Outcome Measure Participant Persons Phenotype Population Post-Acute Sequelae of SARS-CoV-2 Infection Quality of life Recording of previous events Risk Risk Factors SARS-CoV-2 antibody SARS-CoV-2 infection Standardization Symptoms Syndrome T-Lymphocyte Testing Time United States National Institutes of Health Vaccination Virus Diseases adverse outcome biobank cell age circulating biomarkers clinical phenotype cohort comorbidity coronavirus disease disability exhaustion experience frailty high risk human old age (65+)improved insight long-term sequelae low and middle-income countries low socioeconomic status meetings mortality neurocognitive test neuroinflammation neuropsychiatric symptom neuropsychiatry neutralizing antibody novel pandemic disease post SARS-CoV-2 infection post-COVID-19 senescence symptomatic COVID-19 systemic inflammatory response

项目摘要

PROJECT SUMMARY This study will investigate the epidemiology and immunology of neurocognitive symptoms of post-acute sequelae of COVID-19 (PASC, or “long COVID”) in older people living with HIV (PWH). Cognitive decline remains a common and important complication of aging with HIV and is associated with adverse outcomes including frailty, poor quality of life, disability, and death. Lasting neurocognitive symptoms of COVID-19 may be more common in older PWH given their risk factors for PASC as well as differences in underlying immune senescence and inflammation. However, the clinical burden and immunologic phenotypes of neurocognitive symptoms of PASC in older PWH have not been described to date. This information is particularly needed in low- and middle-income countries where heterologous SARS-CoV-2 vaccinations and high COVID-19 incidence were observed. This study will examine (1) the clinical phenotypes and determinants of neuropsychiatric outcomes measures among older PWH with PASC and will seek to determine (2) the immunologic and clinical profiles of older PWH with discordant immunologic and clinical sequelae of SARS- CoV-2 infection. A nested, cross-sectional study using the rich baseline clinical data and biospecimens of the NIA-funded Longitudinal Study of HIV and Aging in Brazil will collect detailed data of COVID-19 infections, symptoms, and prior vaccination to identify older PWH with PASC. A cohort of 300 participants with and without PASC will undergo additional neurocognitive testing to describe specific cognitive phenotypes in older PWH with and without PASC. Further, we will use stored biospecimens to identify older PWH with poor immunologic response to COVID-19 infection and vaccination as well as those with and without PASC to examine differences in adaptive immune senescence and systemic measures of neuroinflammation to identify clues of the immunologic mechanisms contributing to adverse COVID-19 outcomes in this population. Located in one of the epicenters of the COVID-19 pandemic and led by experts in HIV and COVID-19 epidemiology and immunology, this study will offer novel and needed insights into a critical complication of the COVID-19 pandemic in PWH.

项目概要本研究将调查急性后神经认知症状的流行病学和免疫学老年人 HIV 感染者 (PWH) 的 COVID-19 后遗症（PASC，或“长期 COVID”）认知能力下降。仍然是艾滋病毒老龄化的常见且重要的并发症，并与不良后果相关 COVID-19 可能会导致身体虚弱、生活质量差、残疾和死亡。考虑到 PASC 的危险因素以及潜在免疫的差异，老年 PWH 中更常见然而，神经认知的临床负担和免疫表型。迄今为止，尚未描述老年 PWH 中的 PASC 症状，尤其需要此信息。异源 SARS-CoV-2 疫苗接种和 COVID-19 高发的低收入和中等收入国家观察了发病率。本研究将检查（1）临床表型和决定因素。对患有 PASC 的老年 PWH 进行神经精神结果测量，并将寻求确定 (2) 具有不一致的 SARS 免疫学和临床后遗症的老年 PWH 的免疫学和临床特征使用丰富的基线临床数据和生物样本进行 CoV-2 感染的巢式横断面研究。 NIA 资助的巴西 HIV 和老龄化纵向研究将收集 COVID-19 感染的详细数据，一项由 300 名参与者组成的队列。没有 PASC 的患者将接受额外的神经认知测试，以描述老年人的特定认知表型此外，我们将使用储存的生物样本来识别患有不良症状的老年感染者。对 COVID-19 感染和疫苗接种的免疫反应，以及有或没有 PASC 的免疫反应检查适应性免疫衰老和神经炎症的全身测量的差异，以确定导致该人群中 COVID-19 不良结果的免疫机制的线索。位于 COVID-19 大流行的震中之一，由 HIV 和 COVID-19 流行病学专家领导，免疫学方面，这项研究将为 COVID-19 的严重并发症提供新颖且必要的见解艾滋病毒流行期间。