Strengthening the ISMMS research and response capabilities for pathogens of pandemic potential

加强 ISMMS 对大流行病原体的研究和应对能力

• 批准号: 10611770
• 负责人: Randy A. Albrecht
• 金额: $ 231.45万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611770
• 关键词: Address; Air; Animals; Antiviral Agents; Area; Basic Science; Biological; Biology; Biomedical Research; Bunyavirales; COVID-19 pandemic; Cell Culture Techniques; Chemicals; Communicable Diseases; Communities; Contracts; Coronavirus; Decontamination; Department of Defense; Development; Devices; Engineering; Ensure; Faculty; Family; Family Picornaviridae; Filovirus; Flaviviridae; Funding; Grant; Health system; Hospitals; Image; Immunoassay; Industry; Infectious Diseases Research; Influenza; Infrastructure; Institution; International; Investigation; Laboratories; Lead; Medical; Microbiology; Modernization; New York City; Paramyxovirus; Pathogenesis; Pathogenicity; Patient Care; Peer Review; Protocols documentation; Public Health; Publications; RNA; RNA Viruses; Reader; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Safety; System; Togaviridae; Training; Translational Research; Travel; U-Series Cooperative Agreements; United States National Institutes of Health; Virulent; Virus; Virus Diseases; Vision; Work; animal model development; authority; biocontainment facility; biosecurity; drug discovery; emerging pathogen; exhaust; improved; influenzavirus; instrument; medical countermeasure; medical schools; member; metropolitan; novel; operation; pandemic disease; pandemic preparedness; pathogen; pathogenic virus; pre-clinical; programs; recombinant virus; research and development; response; vector-borne

The Icahn School of Medicine at Mount Sinai (ISMMS) is an international leader in medical and scientific training, biomedical research, and patient care. The ISMMS is the medical school for the Mount Sinai Health System (MSHS), which includes eight hospital campuses within the New York City metropolitan area that is a major focal point of international travel. The MSHS leveraged its large metropolitan footprint by establishing pathogen discovery and pandemic surveillance activities. The Department of Microbiology maintains robust research programs that are focused on investigating the biology of new and emerging RNA viruses with pandemic potential and developing novel medical countermeasures against these RNA that are focus of the NIH Antiviral Program for Pandemics (APP). These research programs include pandemic preparedness efforts focused seven RNA virus families or orders of greatest pandemic concern, i.e., Bunyavirales, Coronaviridae, Filoviridae, Flaviviridae, Paramyxoviridae, Picornaviridae, and Togaviridae. Since 2017, faculty members of the Department of Microbiology have co-authored over 250 peer-reviewed publications on these viral pathogens of public health concern. The Department of Microbiology is internationally recognized for its influenza research programs, including investigation of highly pathogenic influenza viruses that require enhanced biocontainment facilities and safety protocols. The BSL-3/ABSL-3 biocontainment facilities are essential shared resources that ensure biosafety and biosecurity of RNA viruses of significant public health concern and to safely conduct research investigating the biology of viral pathogens with pandemic potential. Our application is focused on infrastructure improvements to modernize three biocontainment facilities to improve biosafety, improve efficiency of operations, and expand research capabilities. The first aim of the infrastructure improvements focus on upgrades of the HVAC, autoclaves, biological safety cabinets, and ventilated animal caging systems to modernize and improve the efficiency of operations of the biocontainment facilities. The second aim of the infrastructure improvements to improve biocontainment research workflow on pathogens with pandemic potential focus, including BioTek multimode microplate readers, imaging stations, and a Luminex platform for multiplex immunoassays.

西奈山（ISMMS）的伊坎医学院是医学和科学的国际领导者 培训，生物医学研究和患者护理。 ISMM是西奈山健康的医学院 系统（MSHS），其中包括纽约市大都会地区的八个医院校园 国际旅行的主要焦点。 MSHS通过建立来利用其庞大的大都市足迹 病原体发现和大流行监测活动。微生物学系保持着强大的 研究计划的重点是研究新的和新兴RNA病毒的生物学 大流行潜力并针对这些RNA发展的新型医学对策，这是 NIH抗病毒计划（APP）。这些研究计划包括大流行的准备工作 聚焦七个RNA病毒家族或最大程度上最关心的命令，即Bunyavirales，Coronaviridae， Filoviridae，Flaviviridae，Paramyxoviridae，Picornaviridae和Togaviridae。自2017年以来， 微生物学系与这些病毒病原体合着了250多个同行评审出版物 公共卫生问题。微生物学系因其流感研究而受到国际认可 程序，包括调查需要增强生物植物的高度致病性流感病毒 设施和安全协议。 BSL-3/ABSL-3生物内在设施是必不可少的共同资源 确保重大公共卫生问题的RNA病毒的生物安全和生物安全性并安全进行 研究研究了具有大流行潜力的病毒病原体的生物学。我们的申请专注于 基础设施改进，以现代化三个生物内在设施以改善生物安全，改进 操作效率，并扩大研究能力。基础设施改进的第一个目的 专注于HVAC，高压灭菌，生物安全柜和通风动物笼系统的升级 现代化和提高生物疗养设施运营的效率。第二个目标 基础设施改进，以改善大流行病病原体的生物内在研究工作流程 潜在的焦点，包括Biotek多模片读取器，成像站和Luminex平台 多重免疫测定。