The Neural Mechanisms Associated With Alcohol and Cigarette Craving in Alcohol Use Disorder Smokers During Oxytocin Treatment

催产素治疗期间酒精使用障碍吸烟者与酒精和香烟渴望相关的神经机制

基本信息

批准号：
10608171
负责人：
Kimberly Goodyear
金额：
$ 17.65万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-15 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10608171
关键词：
Addictive Behavior Alcohol consumption Alcohol dependence Alcohols Anterior Anti-Anxiety Agents Applications Grants Area Behavior Behavioral Blood Pressure Brain Cigarette Cigarette Smoker Clinical Clinical Research Clinical Trials Consumption Cues Dependence Development Development Plans Double-Blind Method Etiology Female Functional Magnetic Resonance Imaging Future Gender Goals Health Heart Rate Heavy Drinking Hormones Human Hypothalamic structure Individual Insula of Reil International Unit Intervention Knowledge Laboratory Study Learning Measures Mentored Research Scientist Development Award Mentors Mentorship Methods Modality Moods National Institute on Alcohol Abuse and Alcoholism Neurosecretory Systems Neurotransmitters Nicotine Oxytocin Participant Pathway interactions Patient Self-Report Peptides Persons Pharmaceutical Preparations Pharmacological Treatment Pharmacotherapy Physiological Placebo Control Placebos Population Prevalence Probability Qualifying Randomized Recovery Relapse Research Research Personnel Research Technics Risk Factors Science Signal Transduction Smoke Smoker Smoking Smoking treatment Statistical Methods Substance Use Disorder System Testing Throat Cancer Tobacco Tobacco Dependence Training Training Activity Ventral Striatum addiction alcohol abuse therapy alcohol craving alcohol cue alcohol relapse alcohol response alcohol seeking behavior alcohol use disorder anxious blood oxygen level dependent brain dysfunction career development cigarette craving cigarette smoke cigarette smoking cingulate cortex comorbidity craving cue reactivity drinking efficacy evaluation experience functional MRI scan gray matter high risk human imaging improved knowledgebase male malignant mouth neoplasm multilevel analysis neural neuromechanism novel pre-clinical recruit response sex smoking cessation stress reduction treatment strategy

项目摘要

PROJECT SUMMARY/ABSTRACT This K01 award will provide the support for the attainment of Dr. Kimberly Goodyear’s long-term goals of contributing to treatment discoveries for individuals with an alcohol and smoking comorbidity and advancing the addiction field with rigorous research techniques. As outlined in this K01 proposal, the training activities will afford Dr. Goodyear with excellent mentorship, training and experience to: 1) To learn how to conduct research involving a clinical trial with individuals with alcohol use disorder (AUD); 2) To learn how to conduct research involving a clinical trial with smokers; 3) To gain knowledge working with oxytocin (OXT) as a novel treatment for AUD smokers; 4) To have a background in neuroendocrine pathways to assess the relationship of OXT with the etiology of alcohol and cigarette use; 5) To learn advanced functional magnetic resonance imaging (fMRI) analysis; and 6) To learn multilevel modeling statistical methods. This K01 proposal is especially salient given the serious health consequences associated with and the prevalence of alcohol drinking and smoking. There is a lack of current treatment options for this comorbid group that signals an exigent need for developing efficacious medications. Recent preclinical and human research suggests that OXT may be a potential treatment for alcohol, smoking and other addictive behaviors due to its anxiolytic, stress reducing and anti- craving effects. This proposed research seeks to examine the behavioral and neural substrates of intranasal OXT compared to placebo on alcohol cue-induced alcohol and cigarette craving in AUD smokers. Non treatment-seeking AUD smokers will be recruited to participate in a between-subjects, placebo-controlled, randomized pilot fMRI study. Participants will undergo an fMRI scan in conjunction with an alcohol-olfactory cue-reactivity task. Secondary assessments will include alcohol and cigarette craving, alcohol and cigarette consumption, physiological measures (heart rate and blood pressure) and mood measures. A team of qualified mentors will support Dr. Goodyear with this comprehensive research plan. This proposed research will address the substantial need for developing new pharmacological treatments by advancing the science knowledgebase to improve interventions for individuals who co-use alcohol and cigarettes. This five-year career development plan will facilitate Dr. Goodyear’s transition to an independent clinical researcher and will assist in laying the groundwork for future treatment strategies and grant applications generated from the findings of this research.

项目摘要/摘要该K01奖将为实现金伯利·固特（Kimberly Goodyear）博士的长期目标提供支持为患有酒精和吸烟合并症的人的治疗发现做出贡献具有严格研究技术的成瘾领域。如本K01提案中概述的那样，培训活动将负担得起固特异博士，具有出色的心态，培训和经验：1）学习如何进行研究涉及患有酒精使用障碍的个体的临床试验（AUD）； 2）学习如何进行研究涉及吸烟者的临床试验； 3）获取与氧气（OXT）一起工作的知识作为一种新的治疗方法对于吸烟者； 4）具有神经内分泌途径的背景来评估OXT的关系使用酒精和香烟的病因； 5）学习先进的功能磁共振成像（fMRI）分析； 6）学习多级建模统计方法。这个K01提案特别重要鉴于与饮酒和吸烟有关的严重健康后果以及饮酒的普遍性。这个合并的组缺乏当前的治疗选择，这表明需要开发的需求有效的药物。最近的临床前和人类研究表明，OXT可能是一种潜力由于其抗焦虑，压力减少和抗 - 渴望效果。这项提出的研究旨在检查鼻内的行为和神经底物 OXT与安慰剂在酒精提示引起的酒精和吸烟者中渴望的香烟相比。非寻求治疗的Aud吸烟者将被招募参加，以参加安慰剂对照的对象间随机试验fMRI研究。参与者将与酒精饮料一起进行fMRI扫描提示反应任务。次要评估将包括饮酒和烟，酒精和香烟产犊消费，身体措施（心率和血压）和情绪度量。一支合格的团队导师将通过这项全面的研究计划支持戈德（Goodyear）博士。这项拟议的研究将解决通过促进科学知识基础来开发新的药物治疗的巨大需求为了改善共同利用酒精和香烟的人的干预措施。这个五年的职业发展计划将促进戈德耶（Goodyear）博士向独立临床研究人员的过渡，并将有助于建立这项研究发现产生的未来治疗策略和赠款申请的基础。