Correlates of protective immunity to HCV and rational vaccine design: Admin Core

HCV 保护性免疫与合理疫苗设计的相关性：Admin Core

• 批准号: 10608106
• 负责人: Arash Grakoui
• 金额: $ 9.38万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10608106
• 关键词: Address; Annual Reports; B-Lymphocytes; Biometry; Budgets; Clinical; Collaborations; Communities; Complex; Consultations; Databases; Dedications; Development; Ensure; Goals; Hepatitis C; Hepatitis C virus; Human; Immune response; Immunity; Individual; Infection; Infrastructure; Institution; Intellectual Property; Leadership; Methodology; Modification; Outcome; Patients; Postdoctoral Fellow; Productivity; Publications; Publishing; Research; Research Personnel; Research Project Grants; Resolution; Resource Allocation; Resources; Role; Scientist; Services; Technology Transfer; United States National Institutes of Health; Universities; Vaccine Design; Work; antigen-specific T cells; data management; data sharing; design; graduate student; meetings; nonhuman primate; novel vaccines; programs; response; symposium; vaccination strategy

Abstract In this program, we propose to determine the correlates of protection in individuals that spontaneously clear multiple HCV infection episodes. This will give highly valuable information for the design of next generation of vaccines. Our goal to assess the role of antigen-specific T and B cell responses in infection outcome and to generate an efficacious immune response by vaccination strategies in non-human primates based on emulating successful resolution of natural re-exposure and re-infection in human patients. This U19 proposal consists of 3 Projects and two Cores consisting of an Administrative Core A and a Clinical Core B. The Administrative Core A will provide two functions: (i) provide overall administrative oversight and support for the Program and (ii) provide biostatistical analyses and data management support for the individual projects and Cores. This Administrative Core will be led by Dr. Grakoui at Emory University and will provide the coordination necessary to make effective and efficient use of resources and intermediate results from this collaborative effort. The primary function will be to facilitate scientific interactions between the Project leaders as well as Core leaders. The administrative component will provide the leadership to ensure milestones are met, assessment of the Core functions, modification of scientific goals, incorporation of any new collaborators, decisions of ongoing prioritization and reallocation of resources. Critical decisions will be made in consultation with the Project leaders and program official at NIH. The Administrative Core will file annual reports to the NIH. The Administrative Core will maintain budgets and oversee any re-budgeting that is needed to meet program goals. The biostatistics portion of the Administrative Core will provide data management and statistical support for the three projects. In addition, the Biostatics portion will establish and maintain appropriate database, management and analysis in response to investigators' requests. In order to provide services to meet the analytical challenges the Core will include facilitating methodologies necessary for addressing complex statistical issues encountered in various research projects. In addition, provide essential metrics between the clinicians, scientists and biostatisticians. Having resources dedicated to the biostatistics and data management needs for the research proposed here, will add enormous value to the quality and productivity of the research conducted by the Investigators and to disseminate this information correctly to the scientific community.

抽象的 在此计划中，我们建议确定自发清除的个人的保护相关性 多次 HCV 感染发作。这将为下一代的设计提供非常有价值的信息。 疫苗。我们的目标是评估抗原特异性 T 和 B 细胞反应在感染结果中的作用，并 通过基于仿真的非人类灵长类动物的疫苗接种策略产生有效的免疫反应 成功解决了人类患者的自然再暴露和再感染问题。 该 U19 提案由 3 个项目和两个核心组成，其中包括行政核心 A 和临床核心 核心 B. 行政核心 A 将提供两项职能：(i) 提供全面的行政监督和 对该计划的支持，以及 (ii) 为个人提供生物统计分析和数据管理支持 项目和核心。该行政核心将由埃默里大学的 Grakoui 博士领导，并将提供 有效和高效地利用资源和由此产生的中间成果所必需的协调 协同努力。主要职能是促进项目领导者之间的科学互动 以及核心领导。行政部门将提供领导，以确保实现里程碑， 评估核心职能、修改科学目标、吸收任何新的合作者， 持续优先排序和资源重新分配的决策。重大决定将在协商后做出 与 NIH 的项目负责人和项目官员一起。行政核心将向 NIH 提交年度报告。 行政核心将维持预算并监督满足计划所需的任何重新预算 目标。行政核心的生物统计部分将提供数据管理和统计支持 对于这三个项目。此外，生物统计学部分将建立和维护适当的数据库， 根据调查人员的要求进行管理和分析。为了提供服务以满足 分析挑战 核心将包括促进解决复杂统计所需的方法 各种研究项目中遇到的问题。此外，提供临床医生之间的基本指标， 科学家和生物统计学家。拥有专门满足生物统计和数据管理需求的资源 这里提出的研究将为所进行的研究的质量和生产力增加巨大的价值 由研究人员正确地向科学界传播这些信息。