Developing and testing health warning labels on the ENDS device

开发和测试 ENDS 设备上的健康警告标签

• 批准号: 10609056
• 负责人: Taghrid Asfar
• 金额: $ 53.36万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609056
• 关键词: 21 year old; Affect; Attention; Behavior; Brain; Chemicals; Cigarette; Clinical; Communication; Consensus; Coupled; Cross-Over Studies; Delphi Study; Dependence; Development; Devices; Electronic Nicotine Delivery Systems; Electronic cigarette; Emerging Tobacco Products; Epidemic; Event; Exposure to; Feedback; Focus Groups; Health; High School Student; Industry; Intention; Knowledge; Long-Term Effects; Marketing; Methods; Modality; Modeling; Morbidity - disease rate; Nicotine; Nicotine Dependence; Outcome; Participant; Perception; Performance; Persons; Plasma; Poison; Policy Maker; Randomized; Reaction; Regulation; Reporting; Review Literature; Risk; Safety; Smoker; Surveys; Target Populations; Testing; Text; Time; Tobacco; Tobacco use; United States; Work; Youth; addiction; behavior influence; cigarette smoking; comparison control; design; evidence base; experience; experimental study; follow-up; health application; health communication; health warning; laboratory experiment; mortality; multidisciplinary; nicotine exposure; pilot test; psychologic; public health relevance; recruit; satisfaction; sex; smoking initiation; tobacco control; toxicant; uptake; warning label; young adult

Developing and Testing Health Warnings for ENDS PROJECT SUMMARY The use of electronic nicotine delivery systems (ENDS or e-cigarettes) has reached epidemic levels among young people in the United States (US). ENDS emit toxic substances, including nicotine that irreversibly affects youth’s developing brain leading to dependence and increased risk of cigarette smoking initiation, yet misperceptions about their safety are widespread. Therefore, health communication of ENDS-related risks through Health Warning Labels (HWLs) has been considered as a priority by leading health and regulatory bodies in the US to reduce ENDS use among young people. We have developed and pilot-tested a clinical lab model to examine the potential effects of pictorial HWLs on young (21-29 yrs) ENDS users’ experiences. In this proposal, we will use this model coupled with a systematic development of ENDS pictorial HWLs to test their effect when they are placed on the device on a variety of subjective (e.g. satisfaction, harm perception, nicotine dependence, intention to quit) and objective outcomes (e.g. plasma nicotine, puff topography). This will be done in three stages. First, we will review the literature and develop candidate messages and their associated pictures for the HWLs (n=45). This initial set of HWLs will then be revised and ranked through a Delphi study among tobacco control, regulation, and health communication experts. Second, we will conduct focus groups with young ENDS (21-29 yrs) users to adapt the candidate HWLs to our target population and device itself. Third, we will test HWLs on the ENDS device in a clinical lab cross-over study, where each subject uses ENDS in 2 sessions; 1) their preferred product without HWL (control), and 2) their preferred product with pictorial HWL on the ENDS device. This design will allow us to test our main hypothesis; compared to control, using ENDS with the HWLs is associated with decreased satisfaction, dependence suppression, and puffing behavior, but increased knowledge about harm and intention to quit. This project will guide policymakers into the application of effective HWLs for ENDS and will develop warning messages and pictorials that national and state stakeholders can use through different modalities in counter-marketing campaigns to protect young people and discourage harmful ENDS use.

制定和测试 ENDS 健康警告 项目概要 电子尼古丁输送系统（ENDS 或电子烟）的使用已达到流行程度 美国 (US) 的年轻人会排放有毒物质，其中包括尼古丁，会产生不可逆转的影响。 青少年大脑的发育会导致依赖性并增加吸烟的风险，但 因此，对电子尼古丁传送系统相关风险的健康沟通普遍存在。 通过健康警告标签 (HWL) 已被领先的健康和监管机构视为优先事项 我们开发了一个临床实验室并进行了试点测试。 模型来检查图片 HWL 对年轻（21-29 岁）ENDS 用户体验的潜在影响。 提案中，我们将使用该模型并结合 ENDS 图形 HWL 的系统开发来测试其 当它们被放置在设备上时，会对各种主观影响（例如满意度、伤害感知、尼古丁 依赖性、戒烟意愿）和客观结果（例如血浆尼古丁、烟气分布）。 首先，我们将回顾文献并制定候选信息及其相关内容。 HWL 的图片 (n=45) 随后将通过 Delphi 研究进行修改和排名。 其次，我们将开展焦点小组活动。 与年轻的 ENDS（21-29 岁）用户一起调整候选 HWL 以适应我们的目标人群和设备本身。 第三，我们将在临床实验室交叉研究中测试 ENDS 设备上的 HWL，其中每个受试者都使用 ENDS 分 2 次进行；1) 他们首选的没有 HWL（对照）的产品，以及 2) 他们首选的有图片的产品 ENDS 设备上的 HWL 将使我们能够使用对照来测试我们的主要假设； 带有 HWL 的 ENDS 与满意度降低、依赖抑制和吸烟有关 行为，但增加了对戒烟危害和意图的了解，该项目将指导政策制定者采取行动。 为 ENDS 应用有效的 HWL，并将制定国家和地区的警告信息和图片 国家利益攸关方可以通过不同方式开展反营销活动来保护年轻人 人并阻止有害的 ENDS 使用。

项目成果

Youth Exposure and Response to the FDA Health Warning Label on Electronic Cigarettes Packaging: Policy Implications.

青少年对电子烟包装上 FDA 健康警告标签的接触和反应：政策影响。

• DOI: 10.1093/ntr/ntad175
• 发表时间: 2024
• 期刊: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
• 作者: Asfar,Taghrid;Oluwole,OlusanyaJ;Pan,Yue;Casas,Alejandra;Garayua,AdrianaMaiteHernandez;Schmidt,Michael;Noar,SethM
• 通讯作者: Noar,SethM