Cannabis legalization and use during pregnancy: A Michigan Study

大麻合法化和怀孕期间的使用：密歇根州的一项研究

基本信息

批准号：
10285143
负责人：
Alyssa Vanderziel
金额：
$ 5.39万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-15 至 2022-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10285143
关键词：
21 year old Academia Admission activity Adult Affect Antiemetic Effect Antiemetics Apgar Score Archives Attention Award Belief Birth Birth Records Birth Weight CNR1 gene CNR2 gene Cancer Patient Cannabinoids Cannabis Categories Child Health Cocaine Data Drug usage Endocannabinoids Epidemiology Etiology FDA approved Fetal Development Fetal Growth Fetus First Pregnancy Trimester Gastric Emptying Gastrointestinal tract structure Gestational Age Goals Graph Growth HIV Health Hyperemesis Gravidarum Immune Immune response Immune system Lead Legal Linear Models Link Literature Long-Term Effects Low Birth Weight Infant Malignant Neoplasms Measures Medical Methodology Michigan Midwestern United States Modeling Morning Sickness Mothers National Institute of Drug Abuse Nature Nausea Nausea and Vomiting Neonatal Neonatal Intensive Care Units Outcome Outcome Study Pathologic Pathway interactions Patients Perception Pharmaceutical Preparations Policies Pregnancy Pregnancy Trimesters Pregnant Women Premature Birth Prevalence Prospective cohort study Questionnaires Receptor Activation Reproducibility Research Research Design Research Personnel Retrospective Studies Risk Role Severities Site Small for Gestational Age Infant Specific qualifier value Spontaneous abortion Standardization Subgroup System Term Birth To specify United States Variant Vomiting Vulnerable Populations Woman Work adverse birth outcomes base cannabinoid receptor career design epidemiology study exogenous cannabinoid experience female reproductive system fetal improved infant morbidity marijuana legalization marijuana use marijuana use in pregnancy maternal marijuana use preclinical study preimplantation prenatal prospective recruit reduce symptoms response risk perception success trait vector

项目摘要

PROJECT SUMMARY Maternal cannabis use among pregnant women has doubled over the last few years in the United States (US). Medical and recreational cannabis use is now legal in many states across the nation which has influenced an increase in cannabis use prevalence. Legal expansion might alter cannabis risk perceptions, leading to the potential misguided belief that cannabis is a relatively safe substance. The antiemetic effects of cannabis have been well-established for decades. Because cannabis is used to alleviate nausea and vomiting in cancer patients, it might be thought that cannabis can treat morning sickness. Morning sickness is pregnancy-related nausea and vomiting, and can sometimes be severe (i.e., Hyperemesis gravidarum); it is common among pregnant women in their first trimester of pregnancy. Little is known about the relationship between morning sickness and cannabis use. I propose to estimate the odds of maternal cannabis use given the severity of morning sickness experienced during pregnancy, trimester-by-trimester. Current literature indicates a lack of clear evidence establishing causality between maternal cannabis use and adverse short-term birth outcomes. Studying outcomes such as low birth weight, preterm, birth, small-for- gestational age, Apgar score, neonatal intensive care unit (NICU) admission is important given the potential for long-term effects that result from these infant morbidities. Prior studies lack reproducibility, possibly due to methodological issues such as the use of retrospective study designs. As Michigan became the first state in the Midwest to legalize the recreational use of cannabis by adults at least 21 years of age in 2018, it is imperative to investigate the effects of prenatal cannabis use using a prospective cohort study design. This dissertation proposal aims to estimate the suspected causal link between cannabis use during pregnancy, morning sickness, and a set of birth outcomes (e.g., birth weight, gestational age, preterm birth, Apgar score at birth, and NICU admission following birth) across pregnancy trimesters using data for the Michigan Archive for Research on Child Health (MARCH) study. The support of the NIDA R36 dissertation award will launch me into the role of an independent researcher, and will strengthen my ability to extend this work as an early stage investigator in academia.

项目摘要在过去的几年中，孕妇在孕妇的使用增加了一倍（美国）。现在，在全国许多州，医疗和娱乐性大麻的使用是合法的，这影响了大麻使用率的增加。法律扩张可能会改变大麻的风险感知，导致潜在的误导性相信大麻是一种相对安全的物质。大麻的抗气作用具有数十年来一直建立了良好的。因为大麻用于减轻癌症的恶心和呕吐患者，可能会认为大麻可以治疗孕吐。孕吐与怀孕有关恶心和呕吐，有时可能很严重（即妊娠妊娠）；这很常见孕妇在怀孕的头三个月中。关于早晨之间的关系知之甚少疾病和大麻使用。我建议估计孕产妇大麻使用的几率怀孕期间孕妇孕育，孕妇孕育。当前的文献表明缺乏明确的证据来确定孕产妇使用和不利的短期出生结果。研究结果，例如低出生体重，早产，出生，小小的妊娠年龄，Apgar评分，新生儿重症监护室（NICU）入学很重要这些婴儿的病毒性产生的长期影响。先前的研究缺乏可重复性，可能是由于方法论问题，例如使用回顾性研究设计。随着密歇根州成为中西部第一个使成人娱乐使用大麻合法化合法化的州 2018年21岁，必须研究使用预期的产前大麻的影响队列研究设计。该论文提案旨在估算大麻之间的可疑因果关系在怀孕期间使用，孕吐和一系列出生结果（例如，出生体重，胎龄，早产，出生时的Apgar评分以及出生后的NICU）在怀孕期间使用密歇根州儿童健康研究档案（三月）研究的数据。 NIDA R36的支持论文奖将使我成为独立研究人员的角色，并将增强我的能力作为学术界的早期调查员，扩展了这项工作。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cannabis use and gastrointestinal tract illnesses: The National Health and Nutrition Examination Surveys, 2005-2018.

大麻使用和胃肠道疾病：2005-2018 年国家健康和营养检查调查。

DOI：
10.1111/dar.13609
发表时间：
2023
期刊：
Drug and alcohol review
影响因子：
3.8
作者：
Vanderziel,Alyssa;Alshaarawy,Omayma
通讯作者：
Alshaarawy,Omayma

Nausea and vomiting of pregnancy and prenatal cannabis use in a Michigan sample.

密歇根州样本中怀孕和产前大麻使用引起的恶心和呕吐。

DOI：
10.1016/j.ajogmf.2023.101171
发表时间：
2023
期刊：
American journal of obstetrics & gynecology MFM
影响因子：
6.3
作者：
Vanderziel,Alyssa;Anthony,JamesC;Barondess,David;Kerver,JeanM;Alshaarawy,Omayma
通讯作者：
Alshaarawy,Omayma

Trends and Characteristics of Prenatal Cannabis Use in the U.S., 2002-2019.

2002-2019 年美国产前大麻使用的趋势和特征。