Development of an intraoral device for therapeutic drug monitoring of anti-epileptic drugs

开发用于抗癫痫药物治疗药物监测的口内装置

• 批准号: 10609919
• 负责人: Elain Fu
• 金额: $ 16.71万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-14 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609919
• 关键词: Acceleration; Address; Algorithms; Antiepileptic Agents; Asthma; Beds; Biocompatible Materials; Biological Assay; Biological Markers; Blood; Blood capillaries; Capillarity; Carbamazepine; Caregivers; Chronic Obstructive Pulmonary Disease; Clinic; Clinical; Coupling; Data; Dental; Detection; Development; Devices; Diagnosis; Disease; Dose; Drug Interactions; Drug Kinetics; Drug Monitoring; Drug Side Effects; Electrodes; Electronics; Emerging Technologies; Epilepsy; Feedback; Future; Health; Healthcare; In Vitro; Individual; Intervention; Label; Laboratories; Machine Learning; Measurable; Measurement; Measures; Mental disorders; Microfluidic Microchips; Microfluidics; Modeling; Modification; Monitor; Noise; Oral; Oral cavity; Patients; Performance; Persons; Pharmaceutical Preparations; Process; Saliva; Salivary; Sampling; Secure; Seizures; Serum; Signal Transduction; Symptoms; Technology; Temperature; Therapeutic; Therapeutic Uses; Time; Toxic effect; Translating; Validation; Variant; Viscosity; Work; cross reactivity; dental resin; electronic sensor; handheld mobile device; health application; improved; individual variation; innovation; lamotrigine; meter; personalized health care; personalized management; pharmacologic; point of care; precision medicine; prototype; real time monitoring; salivary assay; sensor; signal processing; standard of care; wireless communication

PROJECT ABSTRACT Saliva is the ideal biofluid for therapeutic drug monitoring applications in general, and specifically for continuous monitoring because it is amenable to measurement noninvasively within the oral cavity. The development of an intraoral device for the continuous real-time monitoring of anti-epileptic drugs in saliva could enable the promise of precision medicine and advancing optimal dosing for each individual. In this project, we will demonstrate feasibility of our proposed intraoral sensor platform by coupling capillarity-based microfluidics and electrochemical detection to ultra-low-power readout electronics, and to use a machine-learning-based approach for offline processing of sensor data, to create an intraoral sensor for the real-time quantification of therapeutic drug levels in saliva in the presence of variation of salivary pH, temperature, and other common confounders. The intraoral sensor will consist of a reusable, comfortable electronics module that will fit securely into the patient’s mouth, and that interfaces with a disposable microfluidic chip containing voltammetry-based detection. The intraoral sensor electronics module will communicate wirelessly with a mobile device that will process the data and display and relay drug levels semi-continuously and in real time.

项目摘要 唾液是一般的治疗药物监测应用的理想生物流体，专门针对 连续监测是因为它可以在口腔内无创测量。这 开发用于连续实时监测唾液中抗癫痫药物的口腔内装置可以 实现精确医学的承诺，并为每个人推进最佳剂量。在这个项目中，我们 通过耦合基于毛细血管的微流体，将证明我们提出的口腔内传感器平台的可行性 和电化学检测到超低功率读数电子设备，并使用基于机器的学习 传感器数据离线处理的方法，创建一个实时数量的口内传感器 在存在唾液pH，温度和其他常见的情况下，唾液中的治疗药物水平 混淆者。口腔内传感器将由可重复使用的舒适电子模块组成，该模块适合 牢固地进入患者的口腔，并与含有的微流体芯片接口 基于伏安法的检测。口内传感器电子模块将与 移动设备将半连续，实时地进行数据并显示和中继药物水平。

项目成果

A Reconfigurable Tri-Mode Frequency-Locked Loop Readout Circuit for Biosensor Interfaces.

用于生物传感器接口的可重构三模式锁频环读出电路。

• DOI: 10.1109/tbcas.2023.3288505
• 发表时间: 2023
• 期刊: IEEE transactions on biomedical circuits and systems
• 影响因子: 5.1
• 作者: Yu,Siyuan;Chou,Tzu-Hsuan;Bose,Soumya;Cook,Jacob;Park,Jaehyeong;Johnston,MatthewL
• 通讯作者: Johnston,MatthewL