Administrative Core

行政核心

• 批准号: 10609943
• 负责人: THOMAS JEFFREY MARTIN
• 金额: $ 14.9万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-15 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609943
• 关键词: Address; Advisory Committees; Animal Husbandry; Clinical; Data Analyses; Databases; Decision Making; Disease; Documentation; Elements; Equipment; Experimental Designs; Goals; Guidelines; Injury; Institution; Journals; Knowledge; Laboratories; Leadership; Manuscripts; Mission; Nervous System; Operative Surgical Procedures; Oxytocin; Pain; Progress Reports; Publications; Quality Control; Reporting; Research; Research Personnel; Resource Allocation; Resource Sharing; Resources; Scanning; Site; Structure; Testing; Travel; Universities; Variant; conflict resolution; forest; innovation; meetings; pre-clinical; preclinical study; prevent; symposium; synergism

For this P01 to fulfill its goal to significantly impact critical barriers to progress in the field of oxytocin as a disease-modifying agent for pain after injury, it needs strong organization and cohesiveness. The Administrative Core will coordinate the activities of the P01 among 9 investigators across 3 institutions through interaction with the P01 leadership structure. The mission of the Administrative Core is to facilitate and assure the application of high-quality standards throughout the P01, to track progress and provide a structure for resource allocation, and to provide a mechanism for resolving problems and assuring integration. We will apply innovative approaches, including documentation of a priori experimental design, assumptions, and data analysis for all preclinical Projects, akin to trial registration in the clinical realm, application of REDCap databases to all preclinical and clinical Projects to allow timely, automated reporting of progress, and application of a newly created variant of StatReviewer to scan manuscripts prior to submission for key elements of transparent reporting requirements. The Administrative Core will serve the following primary aims and functions: Aim 1: Facilitate day to day activities, internal quality control, and review of progress The Administrative Core will coordinate resource sharing, including major equipment, animal husbandry, and surgical facilities within the Pain Mechanisms Laboratory. It will establish a REDCap database for all preclinical and clinical activities and generate monthly automated reports. Finally, it will establish the equivalent of trial registration for preclinical studies. Aim 2: Identify and address needs for changes in course or conflict resolution The Administrative Core will provide resources and structure for decision making regarding the two main reasons for course correction – technical / interpretation stumbling blocks and new knowledge from inside or outside the P01, through review of automated reports and regular meetings, an interactive review of new publications, and advisory and scientific symposia. The Administrative Core will coordinate meetings of the P01 leadership structure to prevent and resolve conflicts. Aim 3: Coordinate dissemination of concepts developed uniquely by the P01 The Administrative Core will facilitate integration and impact of the synergy provided by the P01 through regular discussions of publication and presentation strategies and through internal review of these products prior to release, including scanning for transparent reporting requirements. It will also coordinate presentation of P01 research and progress to the External Advisory Committee and organize an annual symposium.

为了使这个 P01 实现其目标，显着影响催产素领域进展的关键障碍， 作为受伤后疼痛的疾病缓解剂，它需要强大的组织性和凝聚力。 行政核心将通过以下方式协调 3 个机构的 9 名调查员之间的 P01 活动： 与 P01 领导结构的互动 行政核心的使命是促进和确保。 在整个 P01 中应用高质量标准，跟踪进度并提供结构 资源配置，并提供解决问题和确保整合的机制。 创新方法，包括先验实验设计、假设和数据的记录 所有临床前项目的分析，类似于临床领域的试验注册、REDCap 的应用 所有临床前和临床项目的数据库，以便及时、自动地报告进展情况，以及 应用新创建的 StatReviewer 变体在提交密钥之前扫描手稿 透明报告要求的要素。行政核心将服务于以下主要目标。 和功能： 目标 1：促进日常活动、内部质量控制和进度审查 行政核心将协调资源共享，包括主要设备、畜牧业和 疼痛机制实验室内的外科设施将为所有临床前建立一个 REDCap 数据库。 和临床活动并生成每月自动报告最后，它将建立相当于试验的内容。 临床前研究注册。 目标 2：确定并满足改变路线或解决冲突的需求 行政核心将为两个主要方面的决策提供资源和结构 路线修正的原因 – 技术/解释障碍和来自内部或的新知识 在 P01 之外，通过审查自动报告和定期会议，对新的内容进行交互式审查 出版物、咨询和科学研讨会。行政核心将协调委员会的会议。 P01 预防和解决冲突的领导结构。 目标 3：协调传播 P01 独特开发的概念 行政核心将通过 P01 提供的协同作用促进整合和影响 定期讨论出版和演示策略以及对这些产品进行内部审查 在发布之前，包括扫描透明报告要求。 向外部咨询委员会汇报 P01 的研究和进展，并组织年度研讨会。