The Effects of Reduced ACL Stiffness on Dynamic In Vivo Joint Function

降低 ACL 刚度对动态体内关节功能的影响

• 批准号: 10776860
• 负责人: Jillian Elizabeth Beveridge
• 金额: $ 6.98万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10776860
• 关键词: Effects; Reduced; ACL; Stiffness; Dynamic

PROJECT SUMMARY The objective of the proposed study is to establish whether inferior in vivo anterior cruciate ligament (ACL) graft stiffness is sufficient to induce joint motion abnormality. The ACL is the most frequently injured knee ligament. Surgical ligament reconstruction using a tendon graft is the gold standard treatment for an ACL tear, but the procedure does not restore normal joint motion completely and fails to prevent post- traumatic osteoarthritis (PTOA) in many subjects. Why ACL reconstruction fails in these two regards is not completely understood. Much information from animal models and ex vivo experiments suggests that ACL graft stiffness is inferior to that of the native ACL. One of the confounding factors in clinical studies is that different 3D anatomical structure and non-anatomical placement of the ACL graft likely contribute to residual abnormal joint motions that are known to exist. To circumvent the confounders, the proposed study will use an ACL reconstruction animal model and a non-invasive in vivo T2* MR imaging technique to investigate the time course of changes in ACL graft stiffness while using the native ACL as the “graft”. This surgical model simulates the important aspects of bone drilling and graft fixation in clinical ACL reconstruction without introducing the confounding variables described above. In a cross-sectional study design, ACL “graft” stiffness and joint motion will be assessed prior to “reconstruction”, and then at either 6, 12 or 24 weeks. Using this approach, the project will determine whether a threshold in ligament stiffness exists that preserves joint motion, and alongside the outcomes from the mentored K99 study, will provide new insight as to why the current gold standard ACL treatment fails to prevent PTOA. This project also generates new non-invasive tools to monitor functional joint and tissue changes in a clinically relevant model, while establishing the foundation from which to test targets new treatment interventions. Transferring recipient institutions has not changed these study aims, which are largely complete. The remaining 5 months of this project will be carried out at the new institution with activities directed towards augmenting the quantitative MR imaging data and the approach to record joint motion that was developed specifically for this study. The planned dissemination of the current study findings through conference presentations and manuscript publications will benefit from these proposed activities and will be prepared as part of the final study closeout.

项目概要 本研究的目的是确定体内前十字韧带是否存在缺陷 (ACL) 移植物刚度足以引起关节运动异常，ACL 是最常见的。 使用肌腱移植进行韧带重建手术是治疗膝关节韧带损伤的金标准。 ACL 撕裂，但手术不能完全恢复正常的关节运动，也不能防止术后损伤 许多受试者患有创伤性骨关节炎（PTOA），但 ACL 重建在这两方面失败的原因尚不清楚。 来自动物模型和离体实验的大量信息表明 ACL 移植物。 硬度不如天然 ACL，临床研究中的混杂因素之一是不同。 ACL 移植物的 3D 解剖结构和非解剖位置可能导致残留异常 为了规避混杂因素，拟议的研究将使用 ACL。 重建动物模型和非侵入性体内 T2* MR 成像技术来研究时间 使用天然 ACL 作为“移植物”时 ACL 移植物硬度的变化过程。 模拟临床 ACL 重建中骨钻孔和移植物固定的重要方面，无需 引入上述混杂变量在横断面研究设计中，ACL“移植物”刚度。 关节运动将在“重建”之前进行评估，然后在第 6、12 或 24 周时进行评估。 方法，该项目将确定是否存在保持关节运动的韧带硬度阈值， 除了 K99 指导研究的结果之外，还将提供新的见解来解释为什么当前的黄金 标准 ACL 治疗无法预防 PTOA 该项目还产生了新的非侵入性工具来监测。 临床相关模型中的功能性关节和组织变化，同时建立基础 转移接受机构来测试新的治疗干预措施并没有改变这些研究。 该项目的剩余 5 个月将在新基地进行。 机构的活动旨在增强 MR 成像数据和定量方法 记录专门为本研究制定的联合动议。当前计划的传播。 通过会议演讲和手稿出版物得出的研究结果将受益于这些建议 活动并将作为最终研究收尾的一部分进行准备。

项目成果

A transfer learning approach for automatic segmentation of the surgically treated anterior cruciate ligament.

• DOI: 10.1002/jor.24984
• 发表时间: 2022-01
• 期刊: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
• 作者: Flannery SW;Kiapour AM;Edgar DJ;Murray MM;Beveridge JE;Fleming BC
• 通讯作者: Fleming BC

Neuromuscular function in anterior cruciate ligament reconstructed patients at long-term follow-up.

长期随访中前十字韧带重建患者的神经肌肉功能。

• DOI: 10.1016/j.clinbiomech.2020.105231
• 发表时间: 2021-01
• 期刊: Clinical biomechanics (Bristol, Avon)
• 作者: Behnke AL;Parola LR;Karamchedu NP;Badger GJ;Fleming BC;Beveridge JE
• 通讯作者: Beveridge JE

A novel large animal model of posttraumatic osteoarthritis induced by inflammation with mechanical stability.

一种由炎症诱导的具有机械稳定性的新型创伤后骨关节炎大型动物模型。

• 发表时间: 2023
• 期刊: American journal of translational research
• 影响因子: 2.2
• 作者: Sun,Changqi;Chang,Kenny;Fleming,BradenC;Owens,BrettD;Beveridge,JillianE;Gage,Andrew;Talley-Bruns,RachelC;McAllister,Scott;Costa,MegginQ;Pinette,MeganP;Hague,Madalyn;Molino,Janine;Xiao,Ying;Lu,Shaolei;Wei,Lei
• 通讯作者: Wei,Lei

Wavelet analysis reveals differential lower limb muscle activity patterns long after anterior cruciate ligament reconstruction.

• DOI: 10.1016/j.jbiomech.2022.110957
• 发表时间: 2022-03
• 期刊: Journal of biomechanics
• 影响因子: 2.4
• 作者: Zandiyeh P;Parola LR;Fleming BC;Beveridge JE
• 通讯作者: Beveridge JE

Long-Term Bilateral Neuromuscular Function and Knee Osteoarthritis after Anterior Cruciate Ligament Reconstruction.

• DOI: 10.3390/bioengineering10070812
• 发表时间: 2023-07-06
• 期刊: Bioengineering (Basel, Switzerland)