Association of Fraility with Post thyroidectomy alterations in Voice, Swallowing, and Quality of Life

虚弱与甲状腺切除术后声音、吞咽和生活质量改变的关系

基本信息

批准号：
10600548
负责人：
Aarti Mathur
金额：
$ 17.07万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10600548
关键词：
Age Anterior Atrophic Auditory Cervical spine Clinical Clinical Trials Complication Consensus Data Deglutition Deglutition Disorders Development Elderly Endocrine Esophagus Evaluation Exercise Exercise Therapy Family Fluoroscopy Frequencies Friends Functional disorder Funding Future Goiter Incidence Individual Informed Consent Intervention Intervention Studies Interview Language Laryngeal muscle structure Larynx Literature Malignant neoplasm of thyroid Measurement Measures Muscle Nerve Operative Surgical Procedures Outcome Pathologist Patient Outcomes Assessments Patients Personal Satisfaction Pharmaceutical Preparations Phenotype Physiological Postoperative Period Preventive measure Quality of life Randomized Recurrence Reporting Risk Role Societies Speech Speech-Language Pathology Spine surgery Stroboscopy Structure Structure of superior laryngeal nerve Surgeon Surrogate Markers Surveys Therapeutic Intervention Thyroid Gland Thyroid Nodule Thyroidectomy Thyrotropin Trachea Traction Voice Voice Disorders Work base cartilaginous cohort design disability frailty high risk high risk population improved indexing interdisciplinary approach muscle form muscle strength nerve injury prophylactic prospective sarcopenia tool treatment as usual voice therapy young adult

项目摘要

Project Summary This project aims to evaluate the association of frailty with post-operative changes in voice, swallowing, and quality of life following thyroidectomy in older adults. Specifically, Aim 1 is to evaluate the effect of thyroidectomy on voice, swallowing, and quality of life in older adults. The literature suggests that these alterations occur at a relatively high frequency in younger patients. We aim to quantify frequency and magnitude of changes in voice, swallowing, and QOL using subjective assessment with surveys and semi- structured patient interviews. Additionally we aim to correlate this with objective data obtained from speech- language pathology evaluations using videostroboscopy and videofluoroscopy. In Aim 2, we will explore the associations between a frailty phenotype with pre-operative findings, thyroid-specific markers, and post- thyroidectomy alterations in voice, swallowing or decline in QOL. In addition to exploring the role of frailty to predict these alterations and identify a high-risk group, we will also explore the utility of thyroid or laryngeal specific markers to augment the predictive power of frailty. In Aim 3, we hope to investigate the role of pre- operative interventions including tracheal traction exercises and voice therapy to reduce the incidence of impact of post-operative alterations. We will randomize patients to intervention or usual care and evaluate the frequency of alterations after thyroidectomy. This work represents an interdisciplinary approach to establish alterations in voice and swallowing that occur after thyroidectomy in older individuals, the impact of these changes on quality of life, and an attempt to reduce post-surgical disability. Findings from this study will inform the design of 2 future clinical trials aimed at 1) evaluating pre-operative interventions to reduce surgical disability after thyroidectomy and 2) creating a patient-reported outcome measurement tool specifically for older adults undergoing thyroidectomy.

项目摘要该项目旨在评估脆弱的关联与术后声音，吞咽和老年人甲状腺切除术后的生活质量。具体来说，目标1是评估老年人的语音，吞咽和生活质量的甲状腺切除术。文献表明这些在年轻患者中，改变的频率相对较高。我们旨在量化频率和使用主观评估的调查和半结构化的患者访谈。此外，我们旨在将其与从语音获得的客观数据相关联。语言病理学评估使用视频镜检查和视频荧光镜检查。在AIM 2中，我们将探索脆弱的表型与术前发现，甲状腺特异性标记和后的关联甲状腺切除术的声音改变，QOL吞咽或下降。除了探索脆弱的角色预测这些变化并确定一个高风险群体，我们还将探索甲状腺或喉的效用具体标记以增强脆弱的预测能力。在AIM 3中，我们希望调查前手术干预措施，包括气管牵引运动和语音疗法，以减少术后改变的影响。我们将将患者随机进行干预或通常的护理，并评估甲状腺切除术后改变的频率。这项工作代表了建立跨学科的方法老年人甲状腺切除术后发生的声音和吞咽的改变，这些影响的影响生活质量的变化，以及减少手术后残疾的尝试。这项研究的发现将告知两项未来临床试验的设计针对1）评估术前干预措施以减少手术甲状腺切除术后的残疾和2）专门为患者报告的结果测量工具而专门针对老年人接受甲状腺切除术。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Is patient age associated with risk of malignancy in a ≥4 cm cytologically benign thyroid nodule?

DOI：
10.1016/j.amjsurg.2020.05.034
发表时间：
2021-01
期刊：
American journal of surgery
影响因子：
3
作者：
Sutton W;Canner JK;Rooper LM;Prescott JD;Zeiger MA;Mathur A
通讯作者：
Mathur A

Association between age and disease specific mortality in medullary thyroid cancer.

DOI：
10.1016/j.amjsurg.2020.09.025
发表时间：
2021-03
期刊：
AMERICAN JOURNAL OF SURGERY
影响因子：
3
作者：
Sahli, Zeyad T.;Canner, Joseph K.;Zeiger, Martha A.;Mathur, Aarti
通讯作者：
Mathur, Aarti

Thyroidectomy in older adults: an American College of Surgeons National Surgical Quality Improvement Program study of outcomes.

DOI：
10.1016/j.jss.2018.03.057
发表时间：
2018-09
期刊：
The Journal of surgical research
影响因子：
0
作者：
Sahli ZT;Ansari G;Gurakar M;Canner JK;Segev D;Zeiger MA;Mathur A
通讯作者：
Mathur A

Rising Cost of Thyroid Surgery in Adult Patients.

DOI：
10.1016/j.jss.2020.11.049
发表时间：
2021-04
期刊：
The Journal of surgical research
影响因子：
0
作者：
Sahli ZT;Zhou S;Sharma AK;Segev DL;Massie A;Zeiger MA;Mathur A
通讯作者：
Mathur A

Association Between Age and Patient-Reported Changes in Voice and Swallowing After Thyroidectomy.

DOI：
10.1002/lary.27297
发表时间：
2019-03
期刊：
The Laryngoscope
影响因子：
0
作者：
Sahli Z;Canner JK;Najjar O;Schneider EB;Prescott JD;Russell JO;Tufano RP;Zeiger MA;Mathur A
通讯作者：
Mathur A