Next Generation Pediatric Neuroimaging (NGPN) Feasibility

下一代儿科神经影像 (NGPN) 可行性

基本信息

批准号：
10599539
负责人：
Curtis Andrew Corum
金额：
$ 40.74万
依托单位：
CHAMPAIGN IMAGING, LLC
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10599539
关键词：
Acoustics Adult Algorithms Anesthesia procedures Anesthetics Animal Model Brain Brain imaging Child Childhood Clinic Clinical Clinical Research Cognition Communities Computer software Data Data Set Development Diffusion Dimensions Environment Family Functional Magnetic Resonance Imaging General Anesthesia Goals Grant Head Hospitals Housing Human Image Institutional Review Boards Iowa Lead Loudness Magnetic Resonance Magnetic Resonance Imaging Methods Mission Modeling Modification Morphologic artifacts Motion Movement Neurosciences Noise Patients Performance Perfusion Phase Population Preparation Protocols documentation Protons Psychiatry RF coil Radial Ramp Recovery Research Research Personnel Residual state Resolution Risk Scanning Sedation procedure Series Signal Transduction Standardization Technology Testing Time Translating Universities Work brain research bulk motion clinical imaging clinical translation data space density design high dimensionality human imaging image reconstruction imaging biomarker improved neuroimaging next generation novel pediatric patients prevent prototype reconstruction side effect signal processing success tool

项目摘要

Pediatric MR imaging is especially difficult due to motion-related artifacts in the images. Often this requires general anesthesia in the clinic, which has been shown recently to be detrimental to brain development. This places unique barriers on assessment of this population for both clinical and research purposes. In this application, we propose the development of the Next Generation Pediatric Neuroimaging (NGPN) technology, which will allow for high quality MR images to be collected in the presence of motion, thereby eliminating the need for general anesthesia while imaging. This technology will provide the MRI contrasts for proton density, T1, T2, T2*, diffusion, perfusion, and fMRI. The NGPN will be achieved by the development of novel hardware (RF coils and T/R switches), imaging sequences, and image reconstruction tools. These advancements will allow clinicians and researchers to image pediatric subjects in a safer, more reliable and efficient manner.

由于图像中存在与运动相关的伪影，儿童 MR 成像尤其困难。经常这需要在诊所进行全身麻醉，最近的研究表明，不利于大脑发育。这给评估带来了独特的障碍用于临床和研究目的的人群。在此应用中，我们建议下一代儿科神经影像（NGPN）技术的开发，这将允许在存在运动的情况下收集高质量的 MR 图像，从而无需在成像时进行全身麻醉。这项技术将提供质子密度、T1、T2、T2*、扩散、灌注和功能磁共振成像 (fMRI) 的 MRI 对比。 NGPN 将通过开发新型硬件（射频线圈和 T/R 开关）、成像序列和图像重建工具。这些进步将使临床医生和研究人员以更安全、更可靠和更高效的方式对儿科受试者进行成像。